Results 61 to 70 of about 571,868 (347)

Transcriptional regulation of neuropeptide receptors underlies context‐dependent adaptation in Drosophila melanogaster

FEBS Open Bio, EarlyView.
Under environmental changes, the expression level of neuropeptide (NP) and neuropeptide receptor (NPR) genes changes to confer context‐dependent adaptation to the model organism Drosophila melanogaster. Through finding more regulatory elements in the NPR genes in comparison with their ligands (NPs), we found that NPR‐biased transcriptional regulation ...
SeungHeui Ryu, Yanan Wei, Zekun Wu, Tianmu Zhang, DoHoon Lee, Hadi Najafi, Woo Jae Kim   +6 more
wiley   +1 more source

Sharp-Wave Ripples Orchestrate the Induction of Synaptic Plasticity during Reactivation of Place Cell Firing Patterns in the Hippocampus

Cell Reports, 2016
Place cell firing patterns reactivated during hippocampal sharp-wave ripples (SWRs) in rest or sleep are thought to induce synaptic plasticity and thereby promote the consolidation of recently encoded information.
Josef H.L.P. Sadowski, Matthew W. Jones, Jack R. Mellor   +2 more
doaj   +1 more source

Synaptic Plasticity Dynamics for Deep Continuous Local Learning (DECOLLE)

Frontiers in Neuroscience, 2018
A growing body of work underlines striking similarities between biological neural networks and recurrent, binary neural networks. A relatively smaller body of work, however, addresses the similarities between learning dynamics employed in deep artificial
Jacques Kaiser, H. Mostafa, E. Neftci
semanticscholar   +1 more source

A unified model for Duchenne muscular dystrophy gene involvement in cancer: context‐dependent tumour suppression and oncogenicity

FEBS Open Bio, EarlyView.
We propose a context‐dependent model where the Duchenne muscular dystrophy (DMD) gene acts as a tumour suppressor in aggressive tumours and as an oncogene in less aggressive ones. We propose this model as a unified framework to explain the opposing survival associations with DMD expression and to guide experimental exploration of the dual role of DMD ...
Lee Machado, Leanne Jones, Sonika Divakar, Michael Naidoo, Karen Anthony   +4 more
wiley   +1 more source

Diffusion‐based size determination of solute particles: a method adapted for postsynaptic proteins

FEBS Open Bio, EarlyView.
We present a diffusion‐based approach for measuring the size of macromolecules and their complexes, and demonstrate its use on postsynaptic proteins. The method requires fluorescein‐labelled protein samples, a microfluidic device that maintains laminar flow for said samples, a microscope recording the emitted fluorescent signals, and an analytic ...
András László Szabó, Eszter Nagy‐Kanta, Soma Varga, Edit Andrea Jáger, Csaba István Pongor, Mária Laki, András József Laki, Zoltán Gáspári   +7 more
wiley   +1 more source

Calcineurin, Synaptic Plasticity, and Memory [PDF]

The Scientific World JOURNAL, 2001
A long-held hypothesis in neuroscience holds that learning and memory mechanisms involve lasting changes in synaptic weights. Multiple mechanisms for producing such changes exist, of which NMDA-receptor–dependent long-term potentiation (LTP) is the most widely studied.
Carl Weitlauf, Danny G. Winder
openaire   +3 more sources

Correlation Between Irisin and Cognitive Functions in Alzheimer Dementia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The myokine irisin, a recent positive mediator of exercise in the brain, shows neuroprotective functions against Alzheimer's disease (AD). The association between irisin and cognition has never been explored in a biologically defined cohort of patients.
Patrizia Pignataro, Manuela Dicarlo, Chiara Zecca, Daniele Urso, Maria Teresa Dell'Abate, Davide Vilella, Francesco Borlizzi, Roberta Zerlotin, Angela Oranger, Graziana Colaianni, Silvia Colucci, Maria Grano, Giancarlo Logroscino   +12 more
wiley   +1 more source

Hippocampal-dependent navigation in head-fixed mice using a floating real-world environment

Scientific Reports
Head-fixation of mice enables high-resolution monitoring of neuronal activity coupled with precise control of environmental stimuli. Virtual reality can be used to emulate the visual experience of movement during head fixation, but a low inertia floating
Sarah A. Stuart, Jon Palacios-Filardo, Aleks Domanski, Matt Udakis, Ian Duguid, Matt W. Jones, Jack R. Mellor   +6 more
doaj   +1 more source

Synaptic Plasticity Shapes Brain Connectivity: Implications for Network Topology

International Journal of Molecular Sciences, 2019
Studies of brain network connectivity improved understanding on brain changes and adaptation in response to different pathologies. Synaptic plasticity, the ability of neurons to modify their connections, is involved in brain network remodeling following ...
M. Stampanoni Bassi, E. Iezzi, Luana Gilio, D. Centonze, F. Buttari   +4 more
semanticscholar   +1 more source

Aging and Synaptic Plasticity: A Review [PDF]

Neural Plasticity, 2002
Aging affects all systems, but the brain seems to be particularly vulnerable to the action of negative, age‐dependent factors. A gradual loss of memory functions is one of the earliest and most widespread consequences of brain aging. The causes for such impairment are still unclear.
Jorge A. Bergado, William Almaguer
openaire   +4 more sources