Results 61 to 70 of about 326,223 (328)

PSD-95-like membrane associated guanylate kinases (PSD-MAGUKs) and synaptic plasticity [PDF]

, 2011
Activity-dependent modification of excitatory synaptic transmission is a fundamental mechanism for developmental plasticity of the neural circuits and experience-dependent plasticity.
Xu, Weifeng
core   +1 more source

Optogenetics and synaptic plasticity [PDF]

Acta Pharmacologica Sinica, 2013
The intricate and complex interaction between different populations of neurons in the brain has imposed limits on our ability to gain detailed understanding of synaptic transmission and its integration when employing classical electrophysiological approaches. Indeed, electrical field stimulation delivered via traditional microelectrodes does not permit
Yu-feng, Xie, Michael F, Jackson, John F, Macdonald   +2 more
openaire   +2 more sources

Decreased Serum 5‐HT: Clinical Correlates and Regulatory Role in NMJ of MG

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Although 5‐Hydroxytryptamine (5‐HT) indirectly stimulates muscle contraction and participates in regulating Acetylcholine receptor (AChR) cluster homeostasis in cellular, animal, and clinical studies, evidence regarding its potential to modulate muscle contraction in myasthenia gravis (MG) remains limited.
Xinru Shen, Jing Zhang, Xinyue Zhou, Xiaoxiao Yu, Haodong Shang, Shufan Chen, Lulu Zhen, Jinru Wu, Guanlian Hu, Xiaoyan Zhu, Zhan Sun, Yiren Wang, Jiahui Wang, Jie Lv, Xue Zhao, Yingna Zhang, Wei Guo, Ying Peng, Feng Gao   +18 more
wiley   +1 more source

Regional specificity of synaptic plasticity deficits in a knock-in mouse model of DYT1 dystonia

Neurobiology of Disease, 2014
DYT1 dystonia is a movement disorder caused by a deletion in the C-terminal of the protein torsinA. It is unclear how torsinA mutation might disrupt cellular processes encoding motor activity, and whether this impairment occurs in specific brain regions.
G. Martella, M. Maltese, R. Nisticò, T. Schirinzi, G. Madeo, G. Sciamanna, G. Ponterio, A. Tassone, G. Mandolesi, V. Vanni, M. Pignatelli, P. Bonsi, A. Pisani   +12 more
doaj   +1 more source

Caspases in synaptic plasticity [PDF]

Molecular Brain, 2012
Caspases are a family of cysteine proteases that play key roles in programmed cell death (apoptosis). Mounting evidence in recent years shows that caspases also have important non-apoptotic functions in multiple cellular processes, such as synaptic plasticity, dendritic development, learning and memory. In this article, we review the studies on the non-
Li Zheng, Sheng Morgan
openaire   +3 more sources

Clinical Characteristics and Outcomes of Early‐Onset Versus Late‐Onset LGI1‐Antibody Encephalitis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Leucine‐rich glioma‐inactivated 1 antibody (LGI1‐Ab) encephalitis predominantly affected older individuals, but has also been reported in younger patients. However, the demographic, clinical, and prognostic characteristics of early‐onset LGI1‐Ab encephalitis have yet to be systematically elucidated. This study aims to systematically
Yu Kong, Shasha Yu, Jing Zhang, Yu Zu, Yujing Zhang, Jing Lv, Xuyang Cao, Xuedan Feng   +7 more
wiley   +1 more source

Reduced inhibitory synaptic transmission onto striatopallidal neurons may underlie aging-related motor skill deficits

Neurobiology of Disease
Human beings are living longer than ever before and aging is accompanied by an increased incidence of motor deficits, including those associated with the neurodegenerative conditions, Parkinson's disease (PD) and Huntington's disease (HD).
Qiang Shan, Xiaoxuan Yu, Xiaoli Lin, Yao Tian   +3 more
doaj   +1 more source

Ripples Make Waves: Binding Structured Activity and Plasticity in Hippocampal Networks

Neural Plasticity, 2011
Establishing novel episodic memories and stable spatial representations depends on an exquisitely choreographed, multistage process involving the online encoding and offline consolidation of sensory information, a process that is largely dependent on the
Josef H. L. P. Sadowski, Matthew W. Jones, Jack R. Mellor   +2 more
doaj   +1 more source

Synaptoimmunology - roles in health and disease

Molecular Brain, 2017
Mounting evidence suggests that the nervous and immune systems are intricately linked. Many proteins first identified in the immune system have since been detected at synapses, playing different roles in normal and pathological situations.
Robert Nisticò, Eric Salter, Celine Nicolas, Marco Feligioni, Dalila Mango, Zuner A. Bortolotto, Pierre Gressens, Graham L. Collingridge, Stephane Peineau   +8 more
doaj   +1 more source

Developmental sensory experience balances cortical excitation and inhibition. [PDF]

, 2010
Early in life, neural circuits are highly susceptible to outside influences. The organization of the primary auditory cortex (A1) in particular is governed by acoustic experience during the critical period, an epoch near the beginning of postnatal ...
Barker, Alison J, Dorrn, Anja L, Froemke, Robert C, Schreiner, Christoph E, Yuan, Kexin   +4 more
core   +3 more sources