Results 81 to 90 of about 326,223 (328)
A rapamycin-sensitive signaling pathway contributes to long-term synaptic plasticity in the hippocampus [PDF]
, 2002 Many forms of long-lasting behavioral and synaptic plasticity require the synthesis of new proteins. For example, long-term potentiation (LTIP) that endures for more than an hour requires both transcription and translation.
Gingras, Anne-Claude +5 more
core
Neuropsychiatric Symptoms Mimicking Dementia in a Patient Treated With Imatinib
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Tyrosine kinase inhibitors are the cornerstone of chronic myeloid leukemia treatment. Newer agents have more potency and a broader spectrum of action, but also a higher potential for neuropsychiatric side effects. We present a case of a patient on imatinib who developed progressive cognitive, mood, and behavioral alterations.
Ashley Jones +3 more
wiley +1 more source
Forward Table-Based Presynaptic Event-Triggered Spike-Timing-Dependent Plasticity
, 2016 Spike-timing-dependent plasticity (STDP) incurs both causal and acausal synaptic weight updates, for negative and positive time differences between pre-synaptic and post-synaptic spike events.
Augustine, Charles +8 more
core +1 more source
Advanced Functional Materials, EarlyView.A frequency‐tunable ferroelectric synaptic transistor based on a buried‐gate InGaZnO channel and Al2O3/HfO2 dielectric stack exhibits linear and reversible weight updates using single‐polarity pulses. By switching between ferroelectric and trap‐assisted modes depending on input frequency, the device simplifies neuromorphic circuit design and achieves ...
Ojun Kwon +8 more
wiley +1 more source
Neuromorphic Learning towards Nano Second Precision [PDF]
, 2013 Temporal coding is one approach to representing information in spiking neural networks. An example of its application is the location of sounds by barn owls that requires especially precise temporal coding. Dependent upon the azimuthal angle, the arrival
Meier, Karlheinz +3 more
core +1 more source
Advanced Functional Materials, EarlyView.Multicolor optoelectronic synapses are realized by vertically integrating solution‐processed MoS2 thin‐film and SWCNT. The electronically disconnected but interactive MoS2 enables photon‐modulated remote doping, producing a bi‐directional photoresponse.
Jihyun Kim +8 more
wiley +1 more source
Developmental and Activity Dependent Regulation of Ionotropic Glutamate Receptors at Synapses
The Scientific World Journal, 2002 Glutamate receptors mediate the majority of excitatory responses in the central nervous system. The establishment and refinement of glutamatergic synaptic connections depend on the concerted actions of a-amino-3-hydroxy-5-methyl-isoxazole-4-propionate ...
Elek Molnar, John T.R. Isaac
doaj +1 more source
Elevated protein synthesis in microglia causes autism-like synaptic and behavioral aberrations
Nature Communications, 2020 The main cell types involved in autism spectrum disorders through elevated protein synthesis are not well identified. Here, the authors show that overexpression of translation initiation factor eIF4E in microglia results in autism-like behaviour in male,
Zhi-Xiang Xu +15 more
doaj +1 more source
ADAR-mediated RNA editing suppresses sleep by acting as a brake on glutamatergic synaptic plasticity. [PDF]
, 2016 It has been postulated that synaptic potentiation during waking is offset by a homoeostatic reduction in net synaptic strength during sleep. However, molecular mechanisms to support such a process are lacking. Here we demonstrate that deficiencies in the
Dickman, DK +3 more
core
Influence of synaptic depression on memory storage capacity
, 2011 Synaptic efficacy between neurons is known to change within a short time scale dynamically. Neurophysiological experiments show that high-frequency presynaptic inputs decrease synaptic efficacy between neurons.
Abbott L. +12 more
core +1 more source