Results 91 to 100 of about 2,712,162 (368)

Gestational dexamethasone exposure impacts hippocampal excitatory synaptic transmission and learning and memory function with transgenerational effects

Acta Pharmaceutica Sinica B, 2023
The formation of learning and memory is regulated by synaptic plasticity in hippocampal neurons. Here we explored how gestational exposure to dexamethasone, a synthetic glucocorticoid commonly used in clinical practice, has lasting effects on offspring's
Mingcui Luo, Yiwen Yi, Songqiang Huang, Shiyun Dai, Lulu Xie, Kexin Liu, Shuai Zhang, Tao Jiang, Tingting Wang, Baozhen Yao, Hui Wang, Dan Xu   +11 more
doaj   +1 more source

New insights into the mechanisms and sites of action of lamotrigine [PDF]

, 2000
This study was aimed at investigating the effects of lamotrigine (LTG) on electrically evoked field excitatory postsynaptic potentials (fEPSP) and population spikes in the CA1 hippocampal region of guinea pigs.
Grunze, Heinz, Langosch, J. M., Walden, Jörg, Zhou, X. Y.   +3 more
core   +1 more source

Microglia-Dependent Alteration of Glutamatergic Synaptic Transmission and Plasticity in the Hippocampus during Peripheral Inflammation

Journal of Neuroscience, 2015
Peripheral inflammatory diseases are often associated with behavioral comorbidities including anxiety, depression, and cognitive dysfunction, but the mechanism for these is not well understood.
K. Riazi, M. A. Galic, A. C. Kentner, A. Reid, K. Sharkey, Q. Pittman   +5 more
semanticscholar   +1 more source

GLIA modulates synaptic transmission

Brain Research Reviews, 2010
The classical view of glial cells as simple supportive cells for neurons is being replaced by a new vision in which glial cells are active elements involved in the physiology of the nervous system. This new vision is based on the fact that astrocytes, a subtype of glial cells in the CNS, are stimulated by synaptically released neurotransmitters, which ...
Perea, Gertrudis, Araque, Alfonso
openaire   +3 more sources

All‐in‐One Analog AI Hardware: On‐Chip Training and Inference with Conductive‐Metal‐Oxide/HfOx ReRAM Devices

Advanced Functional Materials, EarlyView.
An all‐in‐one analog AI accelerator is presented, enabling on‐chip training, weight retention, and long‐term inference acceleration. It leverages a BEOL‐integrated CMO/HfOx ReRAM array with low‐voltage operation (<1.5 V), multi‐bit capability over 32 states, low programming noise (10 nS), and near‐ideal weight transfer.
Donato Francesco Falcone, Victoria Clerico, Wooseok Choi, Tommaso Stecconi, Folkert Horst, Laura Bégon‐Lours, Matteo Galetta, Antonio La Porta, Nikhil Garg, Fabien Alibart, Bert Jan Offrein, Valeria Bragaglia   +11 more
wiley   +1 more source

Delay-independent stability in bidirectional associative memory networks [PDF]

, 1994
It is shown that if the neuronal gains are small compared with the synaptic connection weights, then a bidirectional associative memory network with axonal signal transmission delays converges to the equilibria associated with exogenous inputs to the ...
Gopalsamy, Kondalsamy, He, Xue-Zhong
core   +1 more source

Transducer Materials Mediated Deep Brain Stimulation in Neurological Disorders

Advanced Functional Materials, EarlyView.
This review discusses advanced transducer materials for improving deep brain stimulation (DBS) in neurological disorders. These materials respond to light, ultrasound, or magnetic fields, enabling precise, less invasive neuromodulation. Their stimulus‐responsive properties enhance neural control and adaptive therapy, paving the way for next‐generation ...
Di Zhao, Zhengyang Cao, Guangjun Zhong, Limin Shi, Junxia Xie, Jianhua Hao   +5 more
wiley   +1 more source

Tet3 regulates synaptic transmission and homeostatic plasticity via DNA oxidation and repair

Nature Neuroscience, 2015
Contrary to the long-held belief that DNA methylation of terminally differentiated cells is permanent and essentially immutable, post-mitotic neurons exhibit extensive DNA demethylation.
Huimei Yu, Yijing Su, Jaehoon Shin, C. Zhong, Junjie U. Guo, Yi-Lan Weng, Fuying Gao, D. Geschwind, Giovanni Coppola, G. Ming, Hongjun Song   +10 more
semanticscholar   +1 more source

Engineering Topographical Cues to Enhance Neural Regeneration in Spinal Cord Injury: Overcoming Challenges and Advancing Therapies

Advanced Functional Materials, EarlyView.
Spinal cord injury (SCI) poses significant challenges for regeneration due to a series of secondary injury mechanisms. How to use biomaterial approach to target the failed regeneration after SCI remains a critical challenge. This review systematically evaluates current strategies to optimize biomaterial topographies for neurite outgrowth, axonal ...
Wei Xu, Fenghui Wang, Joshua Stein, Siqiao Wang, Pengfei Jiang, Letao Yang, Liming Cheng, Ki‐Bum Lee   +7 more
wiley   +1 more source

Maternal Immune Activation Affects Hippocampal Excitatory and Inhibitory Synaptic Transmission in Offspring From an Early Developmental Period to Adulthood

Frontiers in Cellular Neuroscience, 2020
One of the risk factors for schizophrenia is maternal infection. We have previously shown that Polyriboinosinic-polyribocytidylic acid (poly I:C) induced maternal immune activation in mice caused histological changes in the hippocampal CA1 area of ...
Keiju Nakagawa, Hiroki Yoshino, Yoichi Ogawa, Kazuhiko Yamamuro, Sohei Kimoto, Yoshinobu Noriyama, Manabu Makinodan, Masayuki Yamashita, Yasuhiko Saito, Toshifumi Kishimoto   +9 more
doaj   +1 more source