Results 11 to 20 of about 2,725,603 (391)
The CaMKII/NMDA receptor complex controls hippocampal synaptic transmission by kinase-dependent and independent mechanisms [PDF]
Nature Communications, 2018 CaMKII is one of the most studied synaptic proteins, but many critical issues regarding its role in synaptic function remain unresolved. Using a CRISPR-based system to delete CaMKII and replace it with mutated forms in single neurons, we have rigorously ...
Salvatore Incontro +8 more
semanticscholar +4 more sources
Frontiers in Synaptic Neuroscience, 2020 AMPA receptors (AMPARs) are glutamate-gated ion channels that mediate the majority of fast excitatory synaptic transmission throughout the brain. Changes in the properties and postsynaptic abundance of AMPARs are pivotal mechanisms in synaptic plasticity,
Hongyu Zhang, Clive R. Bramham
doaj +2 more sources
Thermal Impact on Spiking Properties in Hodgkin-Huxley Neuron with Synaptic Stimulus [PDF]
, 2007 The effect of environmental temperature on neuronal spiking behaviors is investigated by numerically simulating the temperature dependence of spiking threshold of the Hodgkin-Huxley neuron subject to synaptic stimulus. We find that the spiking threshold exhibits a global minimum in a "comfortable temperature" range where spike initiation needs weakest ...
A. F. Huxley +28 more
arxiv +4 more sources
Pre-post synaptic alignment through neuroligin-1 tunes synaptic transmission efficiency
eLife, 2018 The nanoscale organization of neurotransmitter receptors regarding pre-synaptic release sites is a fundamental determinant of the synaptic transmission amplitude and reliability.
Kalina T Haas +9 more
doaj +2 more sources
Tet3 regulates synaptic transmission and homeostatic plasticity via DNA oxidation and repair [PDF]
Nature Neuroscience, 2015 Contrary to the long-held belief that DNA methylation of terminally differentiated cells is permanent and essentially immutable, post-mitotic neurons exhibit extensive DNA demethylation.
Huimei Yu +10 more
semanticscholar +3 more sources
Formation and Stability of Synaptic Receptor Domains [PDF]
Phys. Rev. Lett. 106, 238104 (2011), 2010 Neurotransmitter receptor molecules, concentrated in postsynaptic domains along with scaffold and a number of other molecules, are key regulators of signal transmission across synapses. Employing experiment and theory, we develop a quantitative description of synaptic receptor domains in terms of a reaction-diffusion model.
Antoine Triller +5 more
arxiv +6 more sources
Synaptic adhesion molecules and excitatory synaptic transmission
Current Opinion in Neurobiology, 2017 Synaptic adhesion molecules have been extensively studied for their contribution to the regulation of synapse development through trans-synaptic adhesions. However, accumulating evidence increasingly indicates that synaptic adhesion molecules are also involved in the regulation of excitatory synaptic transmission and plasticity, often through direct or
Eunjoon Kim, Hyejin Lee, Seil Jang
openaire +4 more sources
Synaptic Cleft Segmentation in Non-Isotropic Volume Electron Microscopy of the Complete Drosophila Brain [PDF]
arXiv, 2018 Neural circuit reconstruction at single synapse resolution is increasingly recognized as crucially important to decipher the function of biological nervous systems. Volume electron microscopy in serial transmission or scanning mode has been demonstrated to provide the necessary resolution to segment or trace all neurites and to annotate all synaptic ...
A Jenett +20 more
arxiv +3 more sources