Results 11 to 20 of about 304,453 (323)

Amyloid-β acts as a regulator of neurotransmitter release disrupting the interaction between synaptophysin and VAMP2. [PDF]

, 2012
BACKGROUND: It is becoming increasingly evident that deficits in the cortex and hippocampus at early stages of dementia in Alzheimer's disease (AD) are associated with synaptic damage caused by oligomers of the toxic amyloid-β peptide (Aβ42).
Alifragis, P, Austen, BM, Beesley, PW, Empson, RM, Russell, CL, Semerdjieva, S   +5 more
core   +5 more sources

Inferring synaptic transmission from the stochastic dynamics of the quantal content: An analytical approach. [PDF]

PLoS Comput Biol
Vahdat Z, Gambrell O, Fisch J, Friauf E, Singh A.   +4 more
europepmc   +2 more sources

Unveiling the Synaptic Function and Structure Using Paired Recordings From Synaptically Coupled Neurons

Frontiers in Synaptic Neuroscience, 2020
Synaptic transmission between neurons is the basic mechanism for information processing in cortical microcircuits. To date, paired recording from synaptically coupled neurons is the most widely used method which allows a detailed functional ...
Guanxiao Qi, Danqing Yang, Chao Ding, Dirk Feldmeyer, Dirk Feldmeyer, Dirk Feldmeyer   +5 more
doaj   +1 more source

The CaMKII/NMDA receptor complex controls hippocampal synaptic transmission by kinase-dependent and independent mechanisms. [PDF]

, 2018
CaMKII is one of the most studied synaptic proteins, but many critical issues regarding its role in synaptic function remain unresolved. Using a CRISPR-based system to delete CaMKII and replace it with mutated forms in single neurons, we have rigorously ...
Asensio, Cedric S, Bender, Kevin J, Díaz-Alonso, Javier, Iafrati, Jillian, Incontro, Salvatore, Nicoll, Roger A, Roche, Katherine W, Sohal, Vikaas S, Vieira, Marta   +8 more
core   +2 more sources

Chronic Ethanol Exposure Enhances Facial Stimulation-Evoked Mossy Fiber–Granule Cell Synaptic Transmission via GluN2A Receptors in the Mouse Cerebellar Cortex

Frontiers in Systems Neuroscience, 2021
Sensory information is transferred to the cerebellar cortex via the mossy fiber–granule cell (MF–GC) pathway, which participates in motor coordination and motor learning.
Bing-Xue Li, Bing-Xue Li, Guang-Hui Dong, Guang-Hui Dong, Hao-Long Li, Hao-Long Li, Jia-Song Zhang, Jia-Song Zhang, Yan-Hua Bing, Chun-Ping Chu, Chun-Ping Chu, Song-Biao Cui, De-Lai Qiu, De-Lai Qiu   +13 more
doaj   +1 more source

Reprogramming glioblastoma multiforme cells into neurons by protein kinase inhibitors

Journal of Experimental & Clinical Cancer Research, 2018
Background Reprogramming of cancers into normal-like tissues is an innovative strategy for cancer treatment. Recent reports demonstrate that defined factors can reprogram cancer cells into pluripotent stem cells. Glioblastoma multiforme (GBM) is the most
Jie Yuan, Fan Zhang, Dennis Hallahan, Zhen Zhang, Liming He, Ling-Gang Wu, Meng You, Qin Yang   +7 more
doaj   +1 more source

Noradrenaline depresses facial stimulation-evoked cerebellar MLI-PC synaptic transmission via α2-AR/PKA signaling cascade in vivo in mice

Scientific Reports, 2023
The noradrenergic fibers of the locus coeruleus, together with mossy fibers and climbing fibers, comprise the three types of cerebellar afferents that modulate the cerebellar neuronal circuit.
Jun-Ya Wang, Wen-Cai Weng, Ting-Qi Wang, Yue Liu, De-Lai Qiu, Mao-Cheng Wu, Chun-Ping Chu   +6 more
doaj   +1 more source

Conversion of Fibroblasts to Neural Cells by p53 Depletion

Cell Reports, 2014
Conversion from fibroblasts to neurons has recently been successfully induced. However, the underlying mechanisms are poorly understood. Here, we find that depletion of p53 alone converts fibroblasts into all three major neural lineages.
Di Zhou, Zhen Zhang, Li-Ming He, Juan Du, Fan Zhang, Chong-Kui Sun, Yu Zhou, Xiao-Wei Wang, Ge Lin, Ke-Ming Song, Ling-Gang Wu, Qin Yang   +11 more
doaj   +1 more source

Differential synaptic mechanism underlying the neuronal modulation of prefrontal cortex, amygdala, and hippocampus in response to chronic postsurgical pain with or without cognitive deficits in rats

Frontiers in Molecular Neuroscience, 2022
Chronic Postsurgical Pain (CPSP) is well recognized to impair cognition, particularly memory. Mounting evidence suggests anatomic and mechanistic overlap between pain and cognition on several levels.
Zhen Li, Zhigang He, Zhixiao Li, Tianning Sun, Wencui Zhang, Hongbing Xiang   +5 more
doaj   +1 more source

Membrane palmitoylated protein 2 is a synaptic scaffold protein required for synaptic SK2-containing channel function

eLife, 2016
Mouse CA1 pyramidal neurons express apamin-sensitive SK2-containing channels in the post-synaptic membrane, positioned close to NMDA-type (N-methyl-D-aspartate) glutamate receptors.
Gukhan Kim, Rafael Luján, Jochen Schwenk, Melissa H Kelley, Carolina Aguado, Masahiko Watanabe, Bernd Fakler, James Maylie, John P Adelman   +8 more
doaj   +1 more source