Results 21 to 30 of about 2,712,162 (368)

Reprogramming glioblastoma multiforme cells into neurons by protein kinase inhibitors

Journal of Experimental & Clinical Cancer Research, 2018
Background Reprogramming of cancers into normal-like tissues is an innovative strategy for cancer treatment. Recent reports demonstrate that defined factors can reprogram cancer cells into pluripotent stem cells. Glioblastoma multiforme (GBM) is the most
Jie Yuan, Fan Zhang, Dennis Hallahan, Zhen Zhang, Liming He, Ling-Gang Wu, Meng You, Qin Yang   +7 more
doaj   +1 more source

Noradrenaline depresses facial stimulation-evoked cerebellar MLI-PC synaptic transmission via α2-AR/PKA signaling cascade in vivo in mice

Scientific Reports, 2023
The noradrenergic fibers of the locus coeruleus, together with mossy fibers and climbing fibers, comprise the three types of cerebellar afferents that modulate the cerebellar neuronal circuit.
Jun-Ya Wang, Wen-Cai Weng, Ting-Qi Wang, Yue Liu, De-Lai Qiu, Mao-Cheng Wu, Chun-Ping Chu   +6 more
doaj   +1 more source

NO signalling in synaptic transmission [PDF]

BMC Pharmacology, 2011
Background The NO/cGMP signaling cascade has been proposed to play a role in long-term potentiation (LTP) and the modulation of synaptic transmission. Nitric oxide is formed enzymatically by NO synthases (NOS); two NOS, the endothelial and neuronal isoform (eNOS, nNOS) produce NO as a signalling molecule.
Thomas Mittmann, Evanthia Mergia, Angela Neitz, Doris Koesling   +3 more
openaire   +2 more sources

Conversion of Fibroblasts to Neural Cells by p53 Depletion

Cell Reports, 2014
Conversion from fibroblasts to neurons has recently been successfully induced. However, the underlying mechanisms are poorly understood. Here, we find that depletion of p53 alone converts fibroblasts into all three major neural lineages.
Di Zhou, Zhen Zhang, Li-Ming He, Juan Du, Fan Zhang, Chong-Kui Sun, Yu Zhou, Xiao-Wei Wang, Ge Lin, Ke-Ming Song, Ling-Gang Wu, Qin Yang   +11 more
doaj   +1 more source

Differential synaptic mechanism underlying the neuronal modulation of prefrontal cortex, amygdala, and hippocampus in response to chronic postsurgical pain with or without cognitive deficits in rats

Frontiers in Molecular Neuroscience, 2022
Chronic Postsurgical Pain (CPSP) is well recognized to impair cognition, particularly memory. Mounting evidence suggests anatomic and mechanistic overlap between pain and cognition on several levels.
Zhen Li, Zhigang He, Zhixiao Li, Tianning Sun, Wencui Zhang, Hongbing Xiang   +5 more
doaj   +1 more source

Secreted amyloid-β precursor protein functions as a GABABR1a ligand to modulate synaptic transmission

Science, 2019
A physiological function for sAPP? Although the pathological role of the amyloid-β precursor protein (APP) in Alzheimer's disease is well studied, the physiological role of this protein has remained elusive. Rice et al. found that the secreted ectodomain
Heather C. Rice, Daniel de Malmazet, An Schreurs, Samuel Frere, I. Van Molle, A. Volkov, Eline Creemers, I. Vertkin, Julie Nys, F. Ranaivoson, D. Comoletti, J. Savas, H. Remaut, D. Balschun, Keimpe D. Wierda, I. Slutsky, K. Farrow, B. de Strooper, Joris de Wit   +18 more
semanticscholar   +1 more source

Membrane palmitoylated protein 2 is a synaptic scaffold protein required for synaptic SK2-containing channel function

eLife, 2016
Mouse CA1 pyramidal neurons express apamin-sensitive SK2-containing channels in the post-synaptic membrane, positioned close to NMDA-type (N-methyl-D-aspartate) glutamate receptors.
Gukhan Kim, Rafael Luján, Jochen Schwenk, Melissa H Kelley, Carolina Aguado, Masahiko Watanabe, Bernd Fakler, James Maylie, John P Adelman   +8 more
doaj   +1 more source

Oxytocin Regulates Synaptic Transmission in the Sensory Cortices in a Developmentally Dynamic Manner

Frontiers in Cellular Neuroscience, 2021
The development and stabilization of neuronal circuits are critical to proper brain function. Synapses are the building blocks of neural circuits. Here we examine the effects of the neuropeptide oxytocin on synaptic transmission in L2/3 pyramidal neurons
Jing Zhang, Jing Zhang, Shu-Jing Li, Wanying Miao, Xiaodi Zhang, Jing-Jing Zheng, Chen Wang, Xiang Yu, Xiang Yu   +8 more
doaj   +1 more source

Gain modulation of synaptic inputs by network state in auditory cortex in vivo [PDF]

, 2015
The cortical network recurrent circuitry generates spontaneous activity organized into Up (active) and Down (quiescent) states during slow-wave sleep or anesthesia.
Destexhe, Alain, Reig, Ramon, Sánchez Vives, María V., Vergara, Ramiro Oscar, Zerlaut, Yann   +4 more
core   +3 more sources

​Synaptic adhesion molecules and excitatory synaptic transmission

Current Opinion in Neurobiology, 2017
Synaptic adhesion molecules have been extensively studied for their contribution to the regulation of synapse development through trans-synaptic adhesions. However, accumulating evidence increasingly indicates that synaptic adhesion molecules are also involved in the regulation of excitatory synaptic transmission and plasticity, often through direct or
Seil Jang, Hyejin Lee, Eunjoon Kim
semanticscholar   +4 more sources