Quantifying constraints determining independent activation on NMDA receptors mediated currents from evoked and spontaneous synaptic transmission at an individual synapse [PDF]
arXiv, 2022 A synapse acts on neural transmission through a chemical process called synapses fusion between pre-synaptic and post-synaptic terminals. Presynaptic terminals release neurotransmitters either in response to action potential or spontaneously independent of presynaptic activity.
arxiv
Adult-born neurons modify excitatory synaptic transmission to existing neurons
eLife, 2016 Adult-born neurons are continually produced in the dentate gyrus but it is unclear whether synaptic integration of new neurons affects the pre-existing circuit.
Elena W. Adlaf +10 more
semanticscholar +1 more source
Advanced Biology, EarlyView.Extracellular vesicles (EVs) play a dual role in diagnostics and therapeutics, offering innovative solutions for treating cancer, cardiovascular, neurodegenerative, and orthopedic diseases. This review highlights EVs’ potential to revolutionize personalized medicine through specific applications in disease detection and treatment.
Farbod Ebrahimi +4 more
wiley +1 more source
Rho GTPase signaling and mDia facilitate endocytosis via presynaptic actin
eLifeNeurotransmission at synapses is mediated by the fusion and subsequent endocytosis of synaptic vesicle membranes. Actin has been suggested to be required for presynaptic endocytosis but the mechanisms that control actin polymerization and its mode of ...
Kristine Oevel +6 more
doaj +1 more source
Synaptic Transmission: An Information-Theoretic Perspective [PDF]
, 1998 Here we analyze synaptic transmission from an information-theoretic perspective. We derive closed-form expressions for the lower-bounds on the capacity of a simple model of a cortical synapse under two explicit coding paradigms.
Koch, C., Manwani, A.
core +2 more sources
The release and trans-synaptic transmission of Tau via exosomes
Molecular Neurodegeneration, 2017 Tau pathology in AD spreads in a hierarchical pattern, whereby it first appears in the entorhinal cortex, then spreads to the hippocampus and later to the surrounding areas.
Yi-peng Wang +10 more
semanticscholar +1 more source
Advanced Functional Materials, EarlyView.This study introduces a conductive nerve guidance conduit integrated with wireless electrical stimulation through alternating magnetic fields, which induces currents and creates a supportive microenvironment for nerve regeneration. In vivo studies show that this approach significantly enhanced myelin restoration, gastrocnemius muscle regeneration ...
Shiheng Liu +7 more
wiley +1 more source
Endogenous Dopamine and Endocannabinoid Signaling Mediate Cocaine-Induced Reversal of AMPAR Synaptic Potentiation in the Nucleus Accumbens Shell [PDF]
, 2018 Repeated exposure to drugs of abuse alters the structure and function of neural circuits mediating reward, generating maladaptive plasticity in circuits critical for motivated behavior.
Ingebretson, Anna E. +3 more
core +3 more sources
Optimal interplay between synaptic strengths and network structure enhances activity fluctuations and information propagation in hierarchical modular networks [PDF]
Brain Sciences 2020, 10, 228, 2019 In network models of spiking neurons, the joint impact of network structure and synaptic parameters on activity propagation is still an open problem. Here we use an information-theoretical approach to investigate activity propagation in spiking networks with hierarchical modular topology.
arxiv +1 more source
Detecting and Estimating Signals over Noisy and Unreliable Synapses: Information-Theoretic Analysis [PDF]
, 2001 The temporal precision with which neurons respond to synaptic inputs has a direct bearing on the nature of the neural code. A characterization of the neuronal noise sources associated with different sub-cellular components (synapse, dendrite, soma, axon,
Koch, Christof, Manwani, Amit
core