Results 81 to 90 of about 2,725,603 (391)

Cortical Excitability Before and After Long‐Term Perampanel Treatment for Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Antiseizure medications (ASMs), which may influence cortical excitability, are the mainstay of epilepsy treatment. Transcranial magnetic stimulation (TMS) helps evaluate cortical excitability. We assessed changes in TMS responses using serial TMS measurements in people treated with an adjunctive noncompetitive AMPA‐receptor ...
Robert M. Helling, Johannes P. van Dijk, Prisca R. Bauer, Roland D. Thijs, Josemir W. Sander, Machiel Zwarts, Gerhard H. Visser   +6 more
wiley   +1 more source

Detecting and Estimating Signals over Noisy and Unreliable Synapses: Information-Theoretic Analysis [PDF]

, 2001
The temporal precision with which neurons respond to synaptic inputs has a direct bearing on the nature of the neural code. A characterization of the neuronal noise sources associated with different sub-cellular components (synapse, dendrite, soma, axon,
Koch, Christof, Manwani, Amit
core  

Astroglia-Derived BDNF and MSK-1 Mediate Experience- and Diet-Dependent Synaptic Plasticity

Brain Sciences, 2020
Experience- and diet-dependent regulation of synaptic plasticity can underlie beneficial effects of active lifestyle on the aging brain. Our previous results demonstrate a key role for brain-derived neurotrophic factor (BDNF) and MSK1 kinase in ...
Ulyana Lalo, Alexander Bogdanov, Guy W. Moss, Yuriy Pankratov   +3 more
doaj   +1 more source

Optimal interplay between synaptic strengths and network structure enhances activity fluctuations and information propagation in hierarchical modular networks [PDF]

Brain Sciences 2020, 10, 228, 2019
In network models of spiking neurons, the joint impact of network structure and synaptic parameters on activity propagation is still an open problem. Here we use an information-theoretical approach to investigate activity propagation in spiking networks with hierarchical modular topology.
arxiv   +1 more source

Patient Selection in Deep Brain Stimulation: A Role for Transcranial Direct Current Stimulation to Enhance the Levodopa Challenge?

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Dopaminergic medication and deep brain stimulation (DBS) improve motor symptoms in Parkinson's disease (PD), but levodopa response alone may not predict DBS outcomes. We retrospectively analyzed 19 PD patients undergoing levodopa challenges with and without prior transcranial direct current stimulation targeting a defined PD response network ...
Lukas L. Goede, Patricia Zvarova, Bahne H. Bahners, Andreas Horn   +3 more
wiley   +1 more source

Synaptic Transmission: An Information-Theoretic Perspective [PDF]

, 1998
Here we analyze synaptic transmission from an information-theoretic perspective. We derive closed-form expressions for the lower-bounds on the capacity of a simple model of a cortical synapse under two explicit coding paradigms.
Koch, C., Manwani, A.
core   +2 more sources

Presynaptic congenital myasthenic syndrome with altered synaptic vesicle homeostasis linked to compound heterozygous sequence variants in RPH3A. [PDF]

, 2018
BackgroundMonogenic defects of synaptic vesicle (SV) homeostasis have been implicated in many neurologic diseases, including autism, epilepsy, and movement disorders.
Burns, Chapman, Chung, Corbalan-Garcia, Cossins, Coudevylle, Deák, Engel, Engel, Foletti, Herrmann, Kato, Kochubey, Palace, Schlüter, Shen, Shen, Shirataki, Staunton, Sun, Tsuboi   +20 more
core   +1 more source

Minireview: pH and synaptic transmission [PDF]

FEBS Letters, 2013
As a general rule a rise in pH increases neuronal activity, whereas it is dampened by a fall of pH. Neuronal activity per se also challenges pH homeostasis by the increase of metabolic acid equivalents. Moreover, the negative membrane potential of neurons promotes the intracellular accumulation of protons.
Anne Sinning, Anne Sinning, Christian A. Hübner   +2 more
openaire   +3 more sources

Equivalence between synaptic current dynamics and heterogeneous propagation delays in spiking neuron networks [PDF]

, 2017
Message passing between components of a distributed physical system is non-instantaneous and contributes to determine the time scales of the emerging collective dynamics like an effective inertia. In biological neuron networks this inertia is due in part to local synaptic filtering of exchanged spikes, and in part to the distribution of the axonal ...
arxiv   +1 more source

Serotonergic and Dopaminergic Function in Neuropsychiatrically Asymptomatic People With HIV on Antiretroviral Therapy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective People with HIV (PWH) on antiretroviral therapy (ART) still experience neurocognitive dysfunction and accelerated brain volume loss. To assess whether the serotonergic and dopaminergic systems are affected, we used [11C]DASB positron emission tomography (PET) to assess presynaptic serotonergic function and [18F]FDOPA PET to measure ...
Chuen‐Yen Lau, Anna Lyndaker, Swati Shah, Paul Wakim, Amelia Mitchell, Cynthia Monroe, Alan Kim, Tracy L. Cropper, Govind Nair, Joseph Snow, Bryan R. Smith, Avindra Nath, Dima A. Hammoud   +12 more
wiley   +1 more source