Results 81 to 90 of about 164,559 (291)

Activity-Induced Regulation of Synaptic Strength through the Chromatin Reader L3mbtl1

Cell Reports, 2018
Summary: Homeostatic synaptic downscaling reduces neuronal excitability by modulating the number of postsynaptic receptors. Histone modifications and the subsequent chromatin remodeling play critical roles in activity-dependent gene expression.
Wenjie Mao, Anna C. Salzberg, Motokazu Uchigashima, Yuto Hasegawa, Hanno Hock, Masahiko Watanabe, Schahram Akbarian, Yuka Imamura Kawasawa, Kensuke Futai   +8 more
doaj   +1 more source

​Synaptic adhesion molecules and excitatory synaptic transmission

Current Opinion in Neurobiology, 2017
Synaptic adhesion molecules have been extensively studied for their contribution to the regulation of synapse development through trans-synaptic adhesions. However, accumulating evidence increasingly indicates that synaptic adhesion molecules are also involved in the regulation of excitatory synaptic transmission and plasticity, often through direct or
Eunjoon Kim, Hyejin Lee, Seil Jang
openaire   +3 more sources

Bi‐Functional Topospecific Nanoparticles to Promote Immune‐Tumor Cell Engagement as A New Immunotherapeutic Strategy

Advanced Materials, EarlyView.
A Janus‐engineered nanoplatform (J‐pHLIP‐PD1), featuring separate tumor‐ and immune‐targeting faces, bridges melanoma cells and cytotoxic T lymphocytes using toposelective pHLIP and anti‐PD‐1 presentation. This strategy elicits robust antitumor responses, promotes immunogenic tumor cell death, suppresses lung metastasis in vivo, and provides a modular,
Alba Ortuño‐Bernal, Sandra Clara‐Trujillo, Elena Lucena‐Sánchez, Francisco J. Hicke, Andrea Escudero, Sandra Pradana‐López, Nelia Jiménez‐Alduan, Paula Díez, Alba García‐Fernández, Ramón Martínez‐Máñez   +9 more
wiley   +1 more source

mGluR5-mediated astrocytes hyperactivity in the anterior cingulate cortex contributes to neuropathic pain in male mice

Communications Biology
Astrocytes regulate synaptic transmission in healthy and pathological conditions, but their involvement in modulating synaptic transmission in chronic pain is unknown.
Weida Shen, Fujian Chen, Yejiao Tang, Yulu Zhao, Linjing Zhu, Liyang Xiang, Li Ning, Wen Zhou, Yiran Chen, Liangxue Wang, Jing Li, Hui Huang, Ling-Hui Zeng   +12 more
doaj   +1 more source

Blocking effects of human tau on squid giant synapse transmission and its prevention by T-817 MA

Frontiers in Synaptic Neuroscience, 2011
Filamentous tau inclusions are hallmarks of Alzheimer’s disease (AD) and related neurodegenerative tauopathies, but the molecular mechanisms involved in tau mediated changes in neuronal function and their possible effects on synaptic transmission are ...
Herman eMoreno, Herman eMoreno, Soonwook eChoi, Soonwook eChoi, Eunah eYu, Eunah eYu, Janaina eBrusco, Janaina eBrusco, Jesus eAvila, Jorge eMoreira, Jorge eMoreira, Mutsuyuki eSugimori, Mutsuyuki eSugimori, Rodolfo R Llinas, Rodolfo R Llinas   +14 more
doaj   +1 more source

Challenges and Opportunities of Upconversion Nanoparticles for Emerging NIR Optoelectronic Devices

Advanced Materials, EarlyView.
The special photo‐responsiveness of upconversion nanoparticles has opened up a new path for the advancement of near‐infrared (NIR)‐responsive optoelectronics. However, challenges such as low energy‐conversion efficiency and high nonradiative losses still persist.
Sunyingyue Geng, Hangfei Li, Ziyu Lv, Yongbiao Zhai, Bobo Tian, Ying Luo, Ye Zhou, Su‐Ting Han   +7 more
wiley   +1 more source

Harnessing Photo‐Energy Conversion in Nanomaterials for Precision Theranostics

Advanced Materials, EarlyView.
Harnessing photo‐energy conversion in nanomaterials enables precision theranostics through light‐driven mechanisms such as photoluminescence, photothermal, photoelectric, photoacoustic, photo‐triggered surface‐enhanced Raman scattering (SERS), and photodynamic processes. This review explores six fundamental principles of photo‐energy conversion, recent
Jingyu Shi, Yadi Fan, Qin Zhang, Yingying Huang, Mo Yang   +4 more
wiley   +1 more source

Neuromorphic Light‐Responsive Organic Matter for in Materia Reservoir Computing

Advanced Materials, EarlyView.
In this work we show that light‐responsive adaptive organic matter can store and process information at the matter level, and emulate neuromorphic functionalities such as short term memory, long term memory and visual memory. Besides demonstrating that material dynamics can be exploited for spatio‐temporal event detection and motion perception, we show
Federico Ferrarese Lupi, Mateo Rosero‐Realpe, Antonio Ocarino, Francesca Frascella, Gianluca Milano, Angelo Angelini   +5 more
wiley   +1 more source

Caffeine Controls Glutamatergic Synaptic Transmission and Pyramidal Neuron Excitability in Human Neocortex

Frontiers in Pharmacology, 2018
Caffeine is the most widely used psychoactive drug, bolstering attention and normalizing mood and cognition, all functions involving cerebral cortical circuits.
Amber Kerkhofs, Amber Kerkhofs, Ana C. Xavier, Beatriz S. da Silva, Paula M. Canas, Sander Idema, Johannes C. Baayen, Samira G. Ferreira, Rodrigo A. Cunha, Rodrigo A. Cunha, Huibert D. Mansvelder   +10 more
doaj   +1 more source

Ionic Conductive Textiles for Wearable Technology

Advanced Materials, EarlyView.
Recent advances in ionic conductive textiles for wearable technology are summarized, with a focus on soft ionic conductors that exhibit skin‐like flexibility and tissue‐like ion dynamics. Their structures, key characteristics, manufacturing methods, and diverse applications are reviewed.
Lingtao Fang, Yunlu Zhou, Qiyao Huang
wiley   +1 more source