Results 1 to 10 of about 125,336 (300)

Synaptic vesicle-omics in mice captures signatures of aging and synucleinopathy [PDF]

Nature Communications
Neurotransmitter release occurs through exocytosis of synaptic vesicles. α-Synuclein’s function and dysfunction in Parkinson’s disease and other synucleinopathies is thought to be tightly linked to synaptic vesicle binding. Age is the biggest risk factor
Virginia Gao, Julita Chlebowicz, Karlton Gaskin, Juan A. Briano, Lauren E. Komer, André Pineda, Shrey Jhalani, Saad Ahmad, Eseosa Uwaifo, Luca S. Black, Jillian E. Haller, Serge Przedborski, Diane A. Lane, Sheng Zhang, Manu Sharma, Jacqueline Burré   +15 more
doaj   +2 more sources

Endocytic protein AP180 assembly domain regulates synaptic vesicle size and release in Caenorhabditis elegans. [PDF]

PLoS Biology
Neuronal communication relies on neurotransmitter release from synaptic vesicles. The endocytic protein AP180 is critical for efficient vesicle recycling at presynaptic terminals, and its loss impairs neurotransmission, producing reduced release ...
Yu Wang, Lanxi Wu, Lin Zhang, Yongming Dong, Aaradhya Pant, Yan Liu, Jihong Bai   +6 more
doaj   +2 more sources

Synaptic Vesicle Glycoprotein 2C: a role in Parkinson’s disease [PDF]

Frontiers in Cellular Neuroscience
Synaptic Vesicle Glycoprotein 2C (SV2C), characterized by its selective expression in discrete brain regions such as the midbrain, has recently emerged as a promising player in Parkinson’s Disease (PD) – a debilitating neurodegenerative disorder ...
Chu Hua Chang, Chu Hua Chang, Kah Leong Lim, Kah Leong Lim, Jia Nee Foo, Jia Nee Foo   +5 more
doaj   +2 more sources

Endosomal sorting protein SNX4 limits synaptic vesicle docking and release [PDF]

eLife
Sorting nexin 4 (SNX4) is an evolutionary conserved organizer of membrane recycling. In neurons, SNX4 accumulates in synapses, but how SNX4 affects synapse function remains unknown.
Josse Poppinga, Nolan J Barrett, L Niels Cornelisse, Matthijs Verhage, Jan RT van Weering   +4 more
doaj   +2 more sources

Caveolin-1 deficiency impairs synaptic transmission in hippocampal neurons

Molecular Brain, 2021
In addition to providing structural support, caveolin-1 (Cav1), a component of lipid rafts, including caveolae, in the plasma membrane, is involved in various cellular mechanisms, including signal transduction. Although pre-synaptic membrane dynamics and
Soulmee Koh, Wongyoung Lee, Sang Myun Park, Sung Hyun Kim   +3 more
doaj   +1 more source

Synaptic vesicle endocytosis [PDF]

Current Opinion in Neurobiology, 1997
Exocytosis of synaptic vesicles is followed rapidly by reinternalization and recycling of their membranes. Recent studies have confirmed the key role of clathrin-mediated endocytosis in synaptic vesicle reformation and have identified new proteins that participate in this process.
CREMONA , OTTAVIO, DE CAMILLI P.
openaire   +3 more sources

Synaptic Vesicle Exocytosis [PDF]

Cold Spring Harbor Perspectives in Biology, 2011
Presynaptic nerve terminals release neurotransmitters by synaptic vesicle exocytosis. Membrane fusion mediating synaptic exocytosis and other intracellular membrane traffic is affected by a universal machinery that includes SNARE (for "soluble NSF-attachment protein receptor") and SM (for "Sec1/Munc18-like") proteins.
Thomas C, Südhof, Josep, Rizo
openaire   +2 more sources

TRPM7 is critical for short-term synaptic depression by regulating synaptic vesicle endocytosis

eLife, 2021
Transient receptor potential melastatin 7 (TRPM7) contributes to a variety of physiological and pathological processes in many tissues and cells. With a widespread distribution in the nervous system, TRPM7 is involved in animal behaviors and neuronal ...
Zhong-Jiao Jiang, Wenping Li, Li-Hua Yao, Badeia Saed, Yan Rao, Brian S Grewe, Andrea McGinley, Kelly Varga, Simon Alford, Ying S Hu, Liang-Wei Gong   +10 more
doaj   +1 more source

Synaptic Vesicle Endocytosis [PDF]

Cold Spring Harbor Perspectives in Biology, 2012
Neurons can sustain high rates of synaptic transmission without exhausting their supply of synaptic vesicles. This property relies on a highly efficient local endocytic recycling of synaptic vesicle membranes, which can be reused for hundreds, possibly thousands, of exo-endocytic cycles. Morphological, physiological, molecular, and genetic studies over
Yasunori, Saheki, Pietro, De Camilli
openaire   +2 more sources

A delay in vesicle endocytosis by a C-terminal fragment of N-cadherin enhances Aβ synaptotoxicity

Cell Death Discovery, 2023
Synaptotoxic Aβ oligomers are thought to play a major role in the early pathology of Alzheimer´s disease (AD). However, the molecular mechanisms involved in Aβ-induced synaptic dysfunction and synapse damage remain largely unclear.
Zenghui Teng, Georgia-Ioanna Kartalou, Sushma Dagar, Patrick C. Fraering, Volkmar Lessmann, Kurt Gottmann   +5 more
doaj   +1 more source