Clarinet (CLA-1), a novel active zone protein required for synaptic vesicle clustering and release
eLife, 2017 Active zone proteins cluster synaptic vesicles at presynaptic terminals and coordinate their release. In forward genetic screens, we isolated a novel Caenorhabditis elegans active zone gene, clarinet (cla-1).
Zhao Xuan +6 more
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Synaptic Vesicle Endocytosis in Different Model Systems
Frontiers in Cellular Neuroscience, 2018 Neurotransmission in complex animals depends on a choir of functionally distinct synapses releasing neurotransmitters in a highly coordinated manner. During synaptic signaling, vesicles fuse with the plasma membrane to release their contents. The rate of
Quan Gan +2 more
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Synaptic vesicle-omics in mice captures signatures of aging and synucleinopathy [PDF]
Nature CommunicationsNeurotransmitter release occurs through exocytosis of synaptic vesicles. α-Synuclein’s function and dysfunction in Parkinson’s disease and other synucleinopathies is thought to be tightly linked to synaptic vesicle binding. Age is the biggest risk factor
Virginia Gao +15 more
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Structural basis of synaptic vesicle assembly promoted by α-synuclein
Nature Communications, 2016 α-synuclein, a protein associated to Parkinson's disease, is involved in synaptic vesicle interaction and assembly. Here, the authors use NMR spectroscopy and super-resolution microscopy to unveil the nature and molecular mechanism of α-synuclein ...
Giuliana Fusco +10 more
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Synaptic vesicle proteins and active zone plasticity
Frontiers in Synaptic Neuroscience, 2016 Neurotransmitter is released from synaptic vesicles at the highly specialized presynaptic active zone. The complex molecular architecture of active zones mediates the speed, precision and plasticity of synaptic transmission.
Robert J Kittel, Manfred eHeckmann
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Vps35 in cooperation with LRRK2 regulates synaptic vesicle endocytosis through the endosomal pathway in Drosophila [PDF]
Human Molecular Genetics, 2017 Tsuyoshi Inoshita +10 more
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Synaptic Vesicle Glycoprotein 2C: a role in Parkinson’s disease [PDF]
Frontiers in Cellular NeuroscienceSynaptic Vesicle Glycoprotein 2C (SV2C), characterized by its selective expression in discrete brain regions such as the midbrain, has recently emerged as a promising player in Parkinson’s Disease (PD) – a debilitating neurodegenerative disorder ...
Chu Hua Chang +5 more
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Endosomal sorting protein SNX4 limits synaptic vesicle docking and release [PDF]
eLifeSorting nexin 4 (SNX4) is an evolutionary conserved organizer of membrane recycling. In neurons, SNX4 accumulates in synapses, but how SNX4 affects synapse function remains unknown.
Josse Poppinga +4 more
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N-acetylation of α-synuclein enhances synaptic vesicle clustering mediated by α-synuclein and lysophosphatidylcholine. [PDF]
ElifeWang C +11 more
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Caveolin-1 deficiency impairs synaptic transmission in hippocampal neurons
Molecular Brain, 2021 In addition to providing structural support, caveolin-1 (Cav1), a component of lipid rafts, including caveolae, in the plasma membrane, is involved in various cellular mechanisms, including signal transduction. Although pre-synaptic membrane dynamics and
Soulmee Koh +3 more
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