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Synaptic vesicle-omics in mice captures signatures of aging and synucleinopathy [PDF]
Nature CommunicationsNeurotransmitter release occurs through exocytosis of synaptic vesicles. α-Synuclein’s function and dysfunction in Parkinson’s disease and other synucleinopathies is thought to be tightly linked to synaptic vesicle binding. Age is the biggest risk factor
Virginia Gao +15 more
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The synaptic vesicle proteome [PDF]
Journal of Neurochemistry, 2007 AbstractSynaptic vesicles are key organelles in neurotransmission. Vesicle integral or membrane‐associated proteins mediate the various functions the organelle fulfills during its life cycle. These include organelle transport, interaction with the nerve terminal cytoskeleton, uptake and storage of low molecular weight constituents, and the regulated ...
Jacqueline Burr
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Synaptic vesicle pools: an update [PDF]
Frontiers in Synaptic Neuroscience, 2010 During the last few decades synaptic vesicles have been assigned to a variety of functional and morphological classes or "pools". We have argued in the past (Rizzoli and Betz, 2005) that synaptic activity in several preparations is accounted for by the function of three vesicle pools: the readily releasable pool (docked at active zones and ready to go ...
Silvio O Rizzoli
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Synaptic vesicle release regulates pre-myelinating oligodendrocyte-axon interactions in a neuron subtype-specific manner [PDF]
Frontiers in Cellular NeuroscienceOligodendrocyte-lineage cells are central nervous system (CNS) glia that perform multiple functions including the selective myelination of some but not all axons.
James R. Gronseth +9 more
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Synaptic Vesicle Endocytosis in Different Model Systems
Frontiers in Cellular Neuroscience, 2018 Neurotransmission in complex animals depends on a choir of functionally distinct synapses releasing neurotransmitters in a highly coordinated manner. During synaptic signaling, vesicles fuse with the plasma membrane to release their contents. The rate of
Quan Gan, Shigeki Watanabe
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Concurrent imaging of synaptic vesicle recycling and calcium dynamics
Frontiers in Molecular Neuroscience, 2011 Synaptic transmission involves the calcium-dependent release of neurotransmitter from synaptic vesicles. Genetically encoded optical probes emitting different wavelengths of fluorescent light in response to neuronal activity offer a powerful approach to
Haiyan Li +2 more
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Metabolic regulation of single synaptic vesicle exo- and endocytosis in hippocampal synapses [PDF]
Cell ReportsSummary: Glucose has long been considered a primary energy source for synaptic function. However, it remains unclear to what extent alternative fuels, such as lactate/pyruvate, contribute to powering synaptic transmission. By detecting individual release
Jongyun Myeong +3 more
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Synaptic Vesicle Glycoprotein 2C: a role in Parkinson’s disease [PDF]
Frontiers in Cellular NeuroscienceSynaptic Vesicle Glycoprotein 2C (SV2C), characterized by its selective expression in discrete brain regions such as the midbrain, has recently emerged as a promising player in Parkinson’s Disease (PD) – a debilitating neurodegenerative disorder ...
Chu Hua Chang +5 more
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Endosomal sorting protein SNX4 limits synaptic vesicle docking and release [PDF]
eLifeSorting nexin 4 (SNX4) is an evolutionary conserved organizer of membrane recycling. In neurons, SNX4 accumulates in synapses, but how SNX4 affects synapse function remains unknown.
Josse Poppinga +4 more
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Actomyosin-mediated inhibition of synaptic vesicle release under CB1R activation [PDF]
Translational PsychiatryLong-term synaptic plasticity is critical for adaptive function of the brain, but presynaptic mechanisms of functional plasticity remain poorly understood.
Maureen H. McFadden +7 more
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