Results 221 to 230 of about 297,963 (299)

Molecular basis for Gβγ-SNARE-mediated inhibition of synaptic vesicle fusion. [PDF]

J Biol Chem
Eitel AR, Mueller BK, Kaya AI, Young M, Cassada JB, Bell EW, Schnitkey L, Zurawski Z, Yim YY, Zhou Q, Meiler J, Hamm HE.   +11 more
europepmc   +1 more source

Prime editing in neuropsychiatric disorders: From mutation‐specific target selection to clinical translation

Neuroprotection, EarlyView.
Abstract Prime editing, a novel clustered regularly interspaced short palindromic repeats (CRISPR)‐based technology, fuses a reverse transcriptase (RT) to an engineered CRISPR‐associated protein 9 (Cas9) and uses a prime editing guide RNA (pegRNA)‐encoded template.
Tianshan Ji, Yuan Zhang, Jinyi Zhao, Yiping Lu, Chengkun Wang   +4 more
wiley   +1 more source

APOE4 triggers dysregulated synaptic vesicle release by disrupting SNARE complex assembly. [PDF]

Cell Mol Life Sci
Chen F, Chen Y, Feng S, Chen H, Deng L, Ma F, Ke Q, Liang Q, Chen J, Peng X, Lu J, Liu Y, Xie Y, Cao H, Sun Y, Wu W, Cui L, Wang Y.   +17 more
europepmc   +1 more source

Restoration, Not Bypass: Otoferlin Gene Therapy and a New Era in Hearing Loss Treatment

Otolaryngology–Head and Neck Surgery, EarlyView.
Abstract The FDA approval of Otarmeni, an AAV‐based gene therapy for biallelic OTOF‐associated sensorineural hearing loss, represents a conceptual shift in otology: from bypassing defective auditory physiology to restoring it. Unlike cochlear implantation, which circumvents damaged sensory structures, OTOF gene replacement targets a synaptic deficit in
Jazlyn A. Selvasingh, Justin R. Shinn
wiley   +1 more source

Dopamine release from Parkinson’s patient-derived neurons is disrupted due to impaired synaptic vesicle loading

Cramb KML, Noor H, Thomas-Wright I, Caiazza MC, Szunyogh S, Milosevic I, Beccano-Kelly D, Cragg SJ, Wade-Martins R.   +8 more
europepmc   +1 more source

TDP-43 Regulates Rab4 Levels to Support Synaptic Vesicle Recycling and Neuromuscular Connectivity in <i>Drosophila</i> and Human ALS Models. [PDF]

Int J Mol Sci
Gbadamosi M, Romano G, Simbula M, Canarutto G, Ottoboni L, Corti S, Feiguin F.   +6 more
europepmc   +1 more source

Stem cell–mediated neuroplasticity and psychological recovery in cancer survivors: Mechanisms, evidence, and translational challenges

Precision Medical Sciences, EarlyView.
Cancer therapies can trigger neuroinflammation and disrupted neuroplasticity, contributing to cognitive impairment and psychological distress in survivors. Stem cells (NSCs/MSCs) and their extracellular vesicles may restore neural niches via trophic support, immunomodulation, synaptic remodeling, and vascular repair, but require rigorous safety, dosing,
Xinyi Yang
wiley   +1 more source

Neural synaptic vesicle autoimmunity following aerosolized porcine neural tissue exposure: insights into autoimmune inflammatory polyradiculoneuropathy. [PDF]

EBioMedicine
Hinson SR, Gupta P, Paramasivan NK, Dyck PJB, Lennon VA, Lachance DH, Knight AM, Rezk M, Karsten C, LaFrance-Corey RG, Staff NP, Hrstka SC, Wu J, Klein CJ, Zekeridou A, McKeon A, Pittock SJ, Lleixà C, Querol L, Dasari S, Mills JR, Dubey D.   +21 more
europepmc   +1 more source

Protective Potentials of Natural Products Against Vascular Dementia: A Comprehensive Review of Experimental Studies

Phytotherapy Research, EarlyView.
ABSTRACT Vascular dementia (VaD), accounting for up to 20% of dementia cases globally, is primarily driven by chronic cerebral hypoperfusion (CCH), which leads to progressive cognitive impairment. Despite the increasing prevalence of VaD, effective treatments remain limited.
Jung‐Hoon Kim, Yongtaek Oh, Suin Cho
wiley   +1 more source

Synaptic Vesicle Glycoprotein 2A Suppresses Amyloidogenesis Beyond Its Synaptic Role: A Novel Mechanism Disrupting BACE1 Binding and Altering APP Localization. [PDF]

Aging Cell
Wang X, Zhang Q, Zhang X, Liu J, Zhang J, Liu C, Cui Y, Song Q, Hou Y, Wang Y, Cao M, Wang P.   +11 more
europepmc   +1 more source