Results 21 to 30 of about 555,224 (393)
Incomplete vesicular docking limits synaptic strength under high release probability conditions
eLife, 2020 Central mammalian synapses release synaptic vesicles in dedicated structures called docking/release sites. It has been assumed that when voltage-dependent calcium entry is sufficiently large, synaptic output attains a maximum value of one synaptic ...
Gerardo Malagon +4 more
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Nature Communications, 2021 Synaptic vesicles store neurotransmitters and fuse with the pre-synaptic membrane when an action potential arrives at the nerve terminal. Here authors apply cross-linking mass spectrometry to study interactions of synaptic vesicle proteins and describe a
Sabine Wittig +7 more
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Astroglial Connexin 43 Regulates Synaptic Vesicle Release at Hippocampal Synapses
Cells, 2023 Connexin 43, an astroglial gap junction protein, is enriched in perisynaptic astroglial processes and plays major roles in synaptic transmission. We have previously found that astroglial Cx43 controls synaptic glutamate levels and allows for activity ...
Giselle Cheung +6 more
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Nature Structural & Molecular Biology, 2008 The core of the neurotransmitter release machinery is formed by SNARE complexes, which bring the vesicle and plasma membranes together and are key for fusion, and by Munc18-1, which controls SNARE-complex formation and may also have a direct role in fusion.
Josep, Rizo, Christian, Rosenmund
openaire +2 more sources
Frontiers in Cellular Neuroscience, 2022 The Tetraspanin (Tsp), CD63, is a transmembrane component of late endosomes and facilitates vesicular trafficking through endosomal pathways. Despite being widely expressed in the human brain and localized to late endosomes, CD63's role in regulating ...
Emily L. Hendricks +4 more
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Activity-dependence of synaptic vesicle dynamics [PDF]
, 2017 The proper function of synapses relies on efficient recycling of synaptic vesicles. The small size of synaptic boutons has hampered efforts to define the dynamical states of vesicles during recycling.
Forte, Luca A +2 more
core +2 more sources
Clathrin coat controls synaptic vesicle acidification by blocking vacuolar ATPase activity
eLife, 2018 Newly-formed synaptic vesicles (SVs) are rapidly acidified by vacuolar adenosine triphosphatases (vATPases), generating a proton electrochemical gradient that drives neurotransmitter loading.
Zohreh Farsi +8 more
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Calcium dependence of neurotransmitter release at a high fidelity synapse
eLife, 2021 The Ca2+-dependence of the priming, fusion, and replenishment of synaptic vesicles are fundamental parameters controlling neurotransmitter release and synaptic plasticity.
Abdelmoneim Eshra +3 more
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Synapsin selectively controls the mobility of resting pool vesicles at hippocampal terminals [PDF]
, 2012 Presynaptic terminals are specialized sites for information transmission where vesicles fuse with the plasma membrane and are locally recycled. Recent work has extended this classical view, with the observation that a subset of functional vesicles is ...
Burden, Jemima J +8 more
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Functional cooperation of α-synuclein and VAMP2 in synaptic vesicle recycling
Alzheimer's & Dementia, 2019 The function of α-synuclein (α-syn) has been long debated, and two seemingly divergent views have emerged. In one, α-syn binds to VAMP2, acting as a SNARE chaperone—but with no effect on neurotransmission—while another posits that α-syn attenuates ...
Jichao Sun +6 more
semanticscholar +1 more source