Results 31 to 40 of about 106,356 (349)

Research progress on vesicle cycle and neurological disorders

Journal of Pharmacy & Pharmaceutical Sciences, 2021
Neurons are special polarized cells whose synaptic vesicles release neurotransmitters into the synaptic cleft, acting on postsynaptic receptors and thus transmitting information from presynaptic to postsynaptic states.
Chengcheng Zhang, Li-Juan Zhu, Ce Chen
doaj   +1 more source

Ontogeny of synaptophysin and synaptoporin in the central nervous system [PDF]

, 1993
The expression of the synaptic vesicle antigens synaptophysin (SY) and synaptoporin (SO) was studied in the rat striatum, which contains a nearly homogeneous population of GABAergic neurons. In situ hybridization revealed high levels of SY transcripts in
B. Marquèze-Pouey, Bergmann, Betz, D. Grabs, Goldman-Rakic, Graybiel, H. Betz, Heimer, Hsu, I. Reisert, Iñiguez, Jahn, Jahn, Kita, Knaus, Lahr, Lauder, Leube, Lindefors, M. Bergmann, M. Gratzl, Marquèze-Pouey, Mugnaini, Newman-Gage, Olson, P. Knaus, Reiner, Reisert, Smith, Specht, Specht, Südhof, Thomas, Vernier, W. Ovtscharoff, Wiedenmann, Wilson   +36 more
core   +1 more source

Fluorescent Measurement of Synaptic Activity Using FM Dyes in Dissociated Hippocampal Cultured Neurons

Bio-Protocol, 2018
Release and recycling of synaptic vesicles are essential for neurotransmission and synaptic plasticity. To gain mechanistic understanding of these processes, direct measurements of vesicle release and retrieval is indispensable.
Roman Lazarenko, Claire DelBove, Qi Zhang   +2 more
doaj   +1 more source

Loss of the Synaptic Vesicle Protein SV2B results in reduced neurotransmission and altered synaptic vesicle protein expression in the retina. [PDF]

PLoS ONE, 2009
The Synaptic Vesicle Protein 2 (SV2) family of transporter-like proteins is expressed exclusively in vesicles that undergo calcium-regulated exocytosis. Of the three isoforms expressed in mammals, SV2B is the most divergent.
Catherine W Morgans, Patricia Kensel-Hammes, James B Hurley, Kimberly Burton, Rejean Idzerda, G Stanley McKnight, Sandra M Bajjalieh   +6 more
doaj   +1 more source

Synaptic proteins promote calcium-triggered fast transition from point contact to full fusion. [PDF]

, 2012
The molecular underpinnings of synaptic vesicle fusion for fast neurotransmitter release are still unclear. Here, we used a single vesicle-vesicle system with reconstituted SNARE and synaptotagmin-1 proteoliposomes to decipher the temporal sequence of ...
Brunger, Axel T, Chu, Steven, Cipriano, Daniel J, Diao, Jiajie, Grob, Patricia, Kyoung, Minjoung, Nguyen, Amie, Nogales, Eva, Padolina, Mark, Shah, Ankita, Shah, Sachi, Srivastava, Ankita, Vrljic, Marija, Zhang, Yunxiang   +13 more
core   +1 more source

Synaptic vesicle fusion [PDF]

Nature Structural & Molecular Biology, 2008
The core of the neurotransmitter release machinery is formed by SNARE complexes, which bring the vesicle and plasma membranes together and are key for fusion, and by Munc18-1, which controls SNARE-complex formation and may also have a direct role in fusion.
Christian Rosenmund, Josep Rizo
openaire   +3 more sources

Identification of a synaptic vesicle-specific membrane protein with a wide distribution in neuronal and neurosecretory tissue. [PDF]

, 1981
Two different monoclonal antibodies, characterized initially as binding synaptic terminal regions of rat brain, bind a 65,000-dalton protein, which is exposed on the outer surface of brain synaptic vesicles. Immunocytochemical experiments at the electron
Matthew, WD, Reichardt, LF, Tsavaler, L
core   +2 more sources

The real catecholamine content of secretory vesicles in the CNS revealed by electrochemical cytometry [PDF]

, 2013
Resolution of synaptic vesicle neurotransmitter content has mostly been limited to the study of stimulated release in cultured cell systems, and it has been controversial as to whether synaptic vesicle transmitter levels are saturated in vivo.
Andrews, A. M., Bressler, A. J., Cans, Ann-Sofie, Ewing, Andrew G, Heien, M. L., Omiatek, D. M.   +5 more
core   +1 more source

Trans-synaptic assemblies link synaptic vesicles and neuroreceptors [PDF]

Science Advances, 2020
AbstractSynaptic transmission is characterized by fast, tightly coupled processes and complex signaling path-ways that require a distinctly non-random spatial organization of their components. Nanoscale organization of synaptic proteins at glutamatergic synapses was suggested to regulate synaptic plasticity, the process underlying learning and memory ...
Antonio Martinez-Sanchez, Antonio Martinez-Sanchez, Vladan Lucic, Wolfgang Baumeister, Christos Papantoniou, Ulrike Laugks, Zdravko Kochovski, Luca Zinzula   +7 more
openaire   +8 more sources

Computational modeling of trans-synaptic nanocolumns, a modulator of synaptic transmission

Frontiers in Computational Neuroscience, 2022
Understanding synaptic transmission is of crucial importance in neuroscience. The spatial organization of receptors, vesicle release properties and neurotransmitter molecule diffusion can strongly influence features of synaptic currents. Newly discovered
Xiaoting Li, Xiaoting Li, Xiaoting Li, Gabriel Hémond, Antoine G. Godin, Antoine G. Godin, Nicolas Doyon, Nicolas Doyon   +7 more
doaj   +1 more source