Trans-synaptic assemblies link synaptic vesicles and neuroreceptors [PDF]
Science Advances, 2021 Tripartite trans-synaptic assemblies directly link pre- and postsynaptic complexes crucial for synaptic transmission.
Antonio Martinez-Sanchez +6 more
openaire +6 more sources
Actin/Myosin-V- and Activity-Dependent Inter-synaptic Vesicle Exchange in Central Neurons
Cell Reports, 2017 Summary: Vesicle sharing between synaptic boutons is an important component of the recycling process that synapses employ to maintain vesicle pools. However, the mechanisms supporting and regulating vesicle transport during the inter-synaptic exchange ...
Michael W. Gramlich, Vitaly A. Klyachko
doaj +1 more source
Effects of Excess Brain-Derived Human α-Synuclein on Synaptic Vesicle Trafficking
Frontiers in Neuroscience, 2021 α-Synuclein is a presynaptic protein that regulates synaptic vesicle trafficking under physiological conditions. However, in several neurodegenerative diseases, including Parkinson’s disease, dementia with Lewy bodies, and multiple system atrophy, α ...
Cristina Román-Vendrell +5 more
doaj +1 more source
LRRK2 phosphorylates pre-synaptic N-ethylmaleimide sensitive fusion (NSF) protein enhancing its ATPase activity and SNARE complex disassembling rate [PDF]
, 2016 Background Lrrk2, a gene linked to Parkinson\u2019s disease, encodes a large scaffolding protein with kinase and GTPase activities implicated in vesicle and cytoskeletal-related processes.
Arrigoni, Giorgio +15 more
core +5 more sources
Vesicle Clustering in a Living Synapse Depends on a Synapsin Region that Mediates Phase Separation
Cell Reports, 2020 Summary: Liquid-liquid phase separation is an increasingly recognized mechanism for compartmentalization in cells. Recent in vitro studies suggest that this organizational principle may apply to synaptic vesicle clusters. Here we test this possibility by
Arndt Pechstein +8 more
doaj +1 more source
Ontogeny of synaptophysin and synaptoporin in the central nervous system [PDF]
, 1993 The expression of the synaptic vesicle antigens synaptophysin (SY) and synaptoporin (SO) was studied in the rat striatum, which contains a nearly homogeneous population of GABAergic neurons. In situ hybridization revealed high levels of SY transcripts in
B. Marquèze-Pouey +36 more
core +1 more source
F1000Research, 2017 Synaptic vesicle recycling is essential for sustained and reliable neurotransmission. A key component of synaptic vesicle recycling is the synaptic vesicle biogenesis process that is observed in synapses and that maintains the molecular identity of ...
Natali L. Chanaday, Ege T. Kavalali
doaj +1 more source
Research progress on vesicle cycle and neurological disorders
Journal of Pharmacy & Pharmaceutical Sciences, 2021 Neurons are special polarized cells whose synaptic vesicles release neurotransmitters into the synaptic cleft, acting on postsynaptic receptors and thus transmitting information from presynaptic to postsynaptic states.
Chengcheng Zhang, Li-Juan Zhu, Ce Chen
doaj +1 more source
JAMA Neurology, 2018 Importance Synaptic loss is well established as the major structural correlate of cognitive impairment in Alzheimer disease (AD). The ability to measure synaptic density in vivo could accelerate the development of disease-modifying treatments for AD ...
Ming-Kai Chen +15 more
semanticscholar +1 more source
Identification of a synaptic vesicle-specific membrane protein with a wide distribution in neuronal and neurosecretory tissue. [PDF]
, 1981 Two different monoclonal antibodies, characterized initially as binding synaptic terminal regions of rat brain, bind a 65,000-dalton protein, which is exposed on the outer surface of brain synaptic vesicles. Immunocytochemical experiments at the electron
Matthew, WD, Reichardt, LF, Tsavaler, L
core +2 more sources