C-terminal calcium binding of α-synuclein modulates synaptic vesicle interaction
Nature Communications, 2018 Alpha-synuclein is known to bind to small unilamellar vesicles (SUVs) via its N terminus, which forms an amphipathic alpha-helix upon membrane interaction.
Janin Lautenschläger +19 more
semanticscholar +1 more source
Synaptic proteins promote calcium-triggered fast transition from point contact to full fusion. [PDF]
, 2012 The molecular underpinnings of synaptic vesicle fusion for fast neurotransmitter release are still unclear. Here, we used a single vesicle-vesicle system with reconstituted SNARE and synaptotagmin-1 proteoliposomes to decipher the temporal sequence of ...
Brunger, Axel T +13 more
core +1 more source
Bio-Protocol, 2018 Release and recycling of synaptic vesicles are essential for neurotransmission and synaptic plasticity. To gain mechanistic understanding of these processes, direct measurements of vesicle release and retrieval is indispensable.
Roman Lazarenko +2 more
doaj +1 more source
Carbonic anhydrase inhibitor acetazolamide shifts synaptic vesicle recycling to a fast mode at the mouse neuromuscular junction [PDF]
, 2017 Acetazolamide (AZ), a molecule frequently used to treat different neurological syndromes, is an inhibitor of the carbonic anhydrase (CA), an enzyme that regulates pH inside and outside cells.
Bertone Cueto, Nicolás Iván +5 more
core +1 more source
Nature Neuroscience, 2017 The synaptic vesicle (SV) protein synaptotagmin-1 (Syt1) is the Ca2+ sensor for fast synchronous release. Biochemical and structural data suggest that Syt1 interacts with phospholipids and SNARE complex, but the manner in which these interactions ...
Shuwen Chang +2 more
semanticscholar +1 more source
Amyloid-β acts as a regulator of neurotransmitter release disrupting the interaction between synaptophysin and VAMP2. [PDF]
, 2012 BACKGROUND: It is becoming increasingly evident that deficits in the cortex and hippocampus at early stages of dementia in Alzheimer's disease (AD) are associated with synaptic damage caused by oligomers of the toxic amyloid-β peptide (Aβ42).
Alifragis, P +5 more
core +6 more sources
Loss of the Synaptic Vesicle Protein SV2B results in reduced neurotransmission and altered synaptic vesicle protein expression in the retina. [PDF]
PLoS ONE, 2009 The Synaptic Vesicle Protein 2 (SV2) family of transporter-like proteins is expressed exclusively in vesicles that undergo calcium-regulated exocytosis. Of the three isoforms expressed in mammals, SV2B is the most divergent.
Catherine W Morgans +6 more
doaj +1 more source
Puzzling Out Synaptic Vesicle 2 Family Members Functions
Frontiers in Molecular Neuroscience, 2017 Synaptic vesicle proteins 2 (SV2) were discovered in the early 80s, but the clear demonstration that SV2A is the target of efficacious anti-epileptic drugs from the racetam family stimulated efforts to improve understanding of its role in the brain. Many
Odile Bartholome +6 more
semanticscholar +1 more source
Newly produced synaptic vesicle proteins are preferentially used in synaptic transmission
EMBO Journal, 2018 Aged proteins can become hazardous to cellular function, by accumulating molecular damage. This implies that cells should preferentially rely on newly produced ones.
Sven Truckenbrodt +7 more
semanticscholar +1 more source
Computational modeling of trans-synaptic nanocolumns, a modulator of synaptic transmission
Frontiers in Computational Neuroscience, 2022 Understanding synaptic transmission is of crucial importance in neuroscience. The spatial organization of receptors, vesicle release properties and neurotransmitter molecule diffusion can strongly influence features of synaptic currents. Newly discovered
Xiaoting Li +7 more
doaj +1 more source