Results 151 to 160 of about 53,984 (298)

SV2A expression in blood cells as a possible biomarker candidate for levetiracetam treatment response

Epilepsia, EarlyView.
Abstract Objective This study was undertaken to evaluate whether synaptic vesicle protein 2A (SV2A) expression on peripheral immune cells predicts treatment response to levetiracetam in epilepsy. Methods High‐dimensional flow cytometry was used to prospectively assess SV2A expression on immune cells from levetiracetam responders, nonresponders, and ...
Johannes Lang, Mathias Linnerbauer, Jeanne Cuny, Veit Rothhammer, Hajo Hamer   +4 more
wiley   +1 more source

Sialidosis type I: How to alleviate disabling myoclonic seizures?—A multicenter analysis of eight cases and review of the literature

Epilepsia Open, EarlyView.
Abstract Objective Sialidosis type I (ST‐1) is an autosomal‐recessive, very rare, progressive lysosomal storage disorder caused by pathogenic variants in NEU1. It is clinically characterized by progressive ataxia, myoclonic seizures (MS), bilateral tonic–clonic seizures (BTCS), and distinctive ophthalmological findings.
Janina Gburek‐Augustat, I‐Chun Lee, Marica Rubino, Vehap Topçu, Melissa Chavez‐Castillo, Shao Ching Tu, Marwan Shinawi, Isabel Alfradique‐Dunham, Manouela Valtcheva, Astrid Adarmes‐Gómez, Daniel Macias‐Garcia, Laura Laura Muñoz‐Delgado, Silvia Jesús, Pablo Mir, Andreas Merkenschlager, Antonietta Coppola   +15 more
wiley   +1 more source

Short Term Memory May Be the Depletion of the Readily Releasable Pool of Presynaptic Neurotransmitter Vesicles [PDF]

, 2008
The Tagging/Retagging model of short term memory was introduced earlier (1) to explain the linear relationship that exists between response time and correct response probability for word recall and recognition: At the initial stimulus presentation words
Tarnow, Dr Eugen
core  

An Analogue Memristor Based on Conjugated Porous Polymer Composite for Artificial Synapse

Exploration, EarlyView.
The conjugated porous polymers integrated with boron‐doped carbon dots form a composite for organic memristor in an artificial synapse. The memristor shows analog‐type resistive switching behavior under ultraviolet irradiation, which is attributed to photoinduced redox.
Haotian Hao, Xiong Jiao, Guangdong Zhou, Lin Chen, Mixue Wang, Jintao He, Xiaochen Lang, Jiyun Zhang, Linlin Shi, Meiwen An, Lingpeng Yan, Yizhi Zhu, Yongzhen Yang   +12 more
wiley   +1 more source

Arrangements of proteins at reconstituted synaptic vesicle fusion sites depend on membrane separation. [PDF]

FEBS Lett, 2020
Ginger L, Malsam J, Sonnen AF, Morado D, Scheutzow A, Söllner TH, Briggs JAG.   +6 more
europepmc   +1 more source

Organic neuromorphic electronics powering intelligent sensory and edge computing systems

InfoMat, EarlyView.
Organic electronic materials are promising candidates for neuromorphic sensing applications, including chemical, physical, visual, and multimodal sensing, owing to their mechanical softness, biocompatibility, and intrinsic ionic–electronic coupling.
Seungjun Woo, Minji Chung, Hyun Woo Song, Seoyoung Kim, Eun Kwang Lee, Joon Hak Oh   +5 more
wiley   +1 more source

Molecular mechanisms that stabilize short term synaptic plasticity during presynaptic homeostatic plasticity. [PDF]

, 2018
Presynaptic homeostatic plasticity (PHP) compensates for impaired postsynaptic neurotransmitter receptor function through a rapid, persistent adjustment of neurotransmitter release, an effect that can exceed 200%.
Davis, Graeme W, Genç, Özgür, Ortega, Jennifer M   +2 more
core   +1 more source

Therapeutic Gene Editing: DNA Repair Pathways, Emerging Editors, and Clinical Progress

iNew Medicine, EarlyView.
ABSTRACT The field of gene editing has evolved rapidly over the past decade, progressing from programmable zinc‐finger nucleases (ZFNs) and transcription activator‐like effector nucleases (TALENs) to the widespread adoption of CRISPR‐Cas systems. First‐generation editors catalyzed genome engineering by introducing targeted double‐strand breaks (DSBs ...
Li‐Kuang Tsai, Youcai Xiong, Dongqi Liu, Dongshan Yang, Jifeng Zhang, Jie Xu, Renzhi Han, Y. Eugene Chen   +7 more
wiley   +1 more source

Synchronous Regeneration: Key Mechanism for Selective Reinnervation in Bilateral Vocal Fold Paralysis

The Laryngoscope, EarlyView.
This study investigates the mechanisms behind the success of selective laryngeal reinnervation surgery in bilateral vocal fold paralysis. In an animal model, the surgery promoted neuromuscular regeneration and restored coordinated vocal fold movement, with no misdirected potentials observed.
Meng Li, Mengjie Chen, Wei Song, Hongliang Zheng, Wei Zhu, Minhui Zhu, Wei Wang, Xianmin Song   +7 more
wiley   +1 more source

Myelination induces axonal hotspots of synaptic vesicle fusion that promote sheath growth.

Curr Biol, 2021
Almeida RG, Williamson JM, Madden ME, Early JJ, Voas MG, Talbot WS, Bianco IH, Lyons DA.   +7 more
europepmc   +1 more source