Results 171 to 180 of about 53,984 (298)

Compartmentalisation in cAMP signalling: A phase separation perspective

British Journal of Pharmacology, EarlyView.
Cells rely on precise spatiotemporal control of signalling pathways to ensure functional specificity. The compartmentalisation of cyclic AMP (cAMP) and protein kinase A (PKA) signalling enables distinct cellular responses within a crowded cytoplasmic space.
Milda Folkmanaite, Manuela Zaccolo
wiley   +1 more source

Munc18-1 is crucial to overcome the inhibition of synaptic vesicle fusion by αSNAP. [PDF]

Nat Commun, 2019
Stepien KP, Prinslow EA, Rizo J.
europepmc   +1 more source

Evaluation of preclinical antipsychotic models used to support first‐in‐human clinical trials

British Journal of Pharmacology, EarlyView.
Abstract Schizophrenia is regarded as a complex and heterogeneous psychiatric disorder, characterised by diverse symptoms and comorbidities, which complicate both clinical management and drug development. Current pharmacological treatment, primarily based on dopamine D2 receptor antagonism or partial agonism, which has not markedly progressed since the
Thi Viet Ha Nguyen, Declan P. McKernan, John P. Kelly   +2 more
wiley   +1 more source

Meta‐analysis of genetic mapping studies in mice reveals candidate epilepsy modifier genes that are outside the current drug development landscape

Epilepsia, EarlyView.
Abstract Objective Despite decades of development in anti‐seizure medications, ~30% of individuals remain refractory to all treatments, and none of the existing therapies are disease modifying. Identifying targets outside the current preclinical paradigm is critically important.
Giovanna L. Durante, Anna L. Tyler, Rod C. Scott, Amanda E. Hernan, J. Matthew Mahoney   +4 more
wiley   +1 more source

Synaptotagmin 1 clamps synaptic vesicle fusion in mammalian neurons independent of complexin. [PDF]

Nat Commun, 2019
Courtney NA, Bao H, Briguglio JS, Chapman ER.   +3 more
europepmc   +1 more source

Treatment approaches in posthypoxic myoclonus: A narrative review with expert opinion

Epilepsia, EarlyView.
Abstract Acute posthypoxic myoclonus (PHM) is a neurological complication that typically emerges within 12–48 h following cardiac arrest, often in comatose patients. It can present as generalized, multifocal, or focal myoclonus and has traditionally been associated with poor prognosis.
Marina Romozzi, Federico Tosto, David García‐Azorín, Luigi Francesco Iannone, Catello Vollono, Paolo Calabresi, Juan Luis Alcala‐Zermeno, Michael R. Sperling   +7 more
wiley   +1 more source

Proteins Involved in Synaptic Vesicle Docking and Fusion

Cold Spring Harbor Symposia on Quantitative Biology, 1995
M.E. Burns, S.A. Beushausen, G.J. Chin, D. Tang, W.M. DeBello, T. Dresbach, V. O'Connor, F.E. Schweizer, S.S.-H. Wang, S.W. Whiteheart, L.A. Hawkey, H. Betz, S.W. Augustine   +12 more
openaire   +2 more sources

Proteostasis of organelles in aging and disease

The FEBS Journal, EarlyView.
Cells rely on regulated proteostasis mechanisms to keep their internal compartments functioning properly. When these mechanisms fail, damaged proteins accumulate, disrupting organelles, such as the nucleus, mitochondria, endoplasmic reticulum, Golgi, and lysosomes, as well as membraneless organelles, such as stress granules, processing bodies, the ...
Yara Nabawi, Cansu Doğan, Dunja Petrović, Gülce Perçin, Seda Koyuncu, David Vilchez   +5 more
wiley   +1 more source

Dynamic nanoscale architecture of synaptic vesicle fusion in mouse hippocampal neurons. [PDF]

Nat Commun
Kroll J, Kravčenko U, Sadeghi M, Diebolder CA, Ivanov L, Lubas M, Sprink T, Schacherl M, Kudryashev M, Rosenmund C.   +9 more
europepmc   +1 more source

Ca²⁺ Regulates the Kinetics of Synaptic Vesicle Fusion at the Afferent Inner Hair Cell Synapse. [PDF]

Front Cell Neurosci, 2018
Huang CH, Moser T.
europepmc   +1 more source