Results 51 to 60 of about 11,302 (215)
Frontiers in Cell and Developmental Biology, 2021 Basal-like breast cancer is characterized by an aggressive clinical outcome and presence of metastasis, for which effective therapies are unavailable.
Satomi Nadanaka +2 more
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Involvement of heparanase in the pathogenesis of acute kidney injury: Nephroprotective effect of PG545 [PDF]
, 2017 Despite the high prevalence of acute kidney injury (AKI) and its association with increased morbidity and mortality, therapeutic approaches for AKI are disappointing. This is largely attributed to poor understanding of the pathogenesis of AKI. Heparanase,
Abassi, Zaid +16 more
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Specific syndecan-1 domains regulate mesenchymal tumor cell adhesion, motility and migration. [PDF]
PLoS ONE, 2011 BackgroundSyndecans are proteoglycans whose core proteins have a short cytoplasmic domain, a transmembrane domain and a large N-terminal extracellular domain possessing glycosaminoglycan chains. Syndecans are involved in many important cellular processes.
Fang Zong +9 more
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Hypertension, 2010 Cardiac fibrosis is characterized by net accumulation of extracellular matrix in the myocardium and is an integral component of most cardiac pathological conditions. Fibrotic remodeling of the ventricle has profound consequences on cardiac function. Increased deposition of interstitial collagen in the perimysial space is initially associated with a ...
openaire +2 more sources
Osteoprotegerin Contributes to the Metastatic Potential of Cells with a Dysfunctional TSC2 Tumor-Suppressor Gene [PDF]
, 1974 In addition to its effects on bone metabolism, osteoprotegerin (OPG), a soluble member of the tumor necrosis factor family of receptors, promotes smooth muscle cell proliferation and migration and may act as a survival factor for tumor cells.
Steagall, Wendy K. +6 more
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Syndecan-1 Promotes Hepatocyte-Like Differentiation of Hepatoma Cells Targeting Ets-1 and AP-1
Biomolecules, 2020 Syndecan-1 is a transmembrane heparan sulfate proteoglycan which is indispensable in the structural and functional integrity of epithelia. Normal hepatocytes display strong cell surface expression of syndecan-1; however, upon malignant transformation ...
Péter Hollósi +10 more
doaj +1 more source
Primordial odontogenic tumor : an immunohistochemical profile [PDF]
, 2017 Primordial Odontogenic Tumor (POT) is a recently described odontogenic tumor characterized by a variably cellular loose fibrous tissue with areas similar to the dental papilla, covered by cuboidal to columnar epithelium that resembles the internal ...
Bologna Molina, Ronell +5 more
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Frontiers in Pharmacology, 2022 Purpose: We aimed to examine the prognostic value of syndecan-1 as a marker of glycocalyx injury in patients with acute ischemic stroke (AIS) receiving rt-PA intravenous thrombolysis.Methods: The study included 108 patients with AIS treated with rt-PA ...
Fangfang Zhao +20 more
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ADAMTS proteinases: a multi-domain, multi-functional family with roles in extracellular matrix turnover and arthritis [PDF]
, 2005 Members of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) family are known to influence development, angiogenesis, coagulation and progression of arthritis.
Jones, GC, Riley, GP
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Functional Characterization of Mouse Syndecan-1 Promoter [PDF]
Journal of Biological Chemistry, 1996 The members of the syndecan family are temporally and spatially expressed heparan sulfate proteoglycans of various tissues, where they mediate extracellular influences on cell morphology and behavior. Functional characterization of the mouse syndecan-1 promoter was carried out in order to elucidate the mechanisms involved in the maintenance of the high
Panu Jaakkola +4 more
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