Results 81 to 90 of about 24,713 (214)

CD168 Identifies Proliferating Pancreatic Islet Cells in Murine and Human

Advanced Science, EarlyView.
This study identifies CD168 as a conserved surface marker for proliferating β‐cells in mouse, human islets, and pancreatic islet tumors. CD168⁺ cells show high proliferation and low insulin expression. CD168+ cells form mostly uni‐β lineage clones, and some of the clones are multi‐lineage.
Shubo Yuan, Jiafu Li, Min Shao, Haili Bao, Ajun Geng, Jialin Yang, Yu Tao, Xinyi Chen, Tianxiong Xiao, Chunye Liu, Zhiyao Xie, Wenqian Song, Qing Cissy Yu, Hongxing Fu, Xu Han, Taochen He, Wenquan Wang, Jianfeng Chen, Sheng Yan, Shaohua Song, Liang Liu, Yi Arial Zeng   +21 more
wiley   +1 more source

The monoclonal antibody nBT062 conjugated to maytansinoids has potent and selective cytotoxicity against CD138 positive multiple myeloma cells _in vitro_ and _in vivo_ [PDF]

, 2008
CD138 (Syndecan1) is highly expressed on multiple myeloma (MM) cells. In this study, we examined the anti-MM effect of murine/human chimeric CD138-specific monoclonal antibody (mAb) nBT062 conjugated with highly cytotoxic maytansinoid derivatives _in ...
Benjamin Dä, Christoph Uherek, Diana Cristea, Frank Osterroth, Giulia Perrone, Hiroshi Ikeda, Hiroshi Yasui, Kenneth C. Anderson, Loredana Santo, Mariateresa Fulciniti, Nikhil C. Munshi, Noopur S. Raje, Paul Richardson, Robert J. Lutz, Samantha Pozzi, Silkie Aigner, Sonia Vallet, Tanyel Kiziltepe, Teru Hideshima, Yu-Tzu Tai, Yutaka Okawa   +20 more
core   +1 more source

The Role of Syndecan-1 in Malignancies

Annals of Medicine, 1996
Syndecans form a family of cell surface proteoglycans, which can interact with various effector molecules, such as extracellular matrix (ECM) molecules and growth factors. Syndecan-1 is the most extensively studied member of the syndecan family. It is found mainly in epithelial cells, but its expression is developmentally regulated during embryonic ...
P, Inki, M, Jalkanen
openaire   +2 more sources

Syndecan-1 as a Regulator of Chemokine Function [PDF]

The Scientific World JOURNAL, 2003
Chemokines are a family of chemotactic cytokines that play critical roles in leukocyte recruitment to sites of inflammation. Characterized by the presence of conserved aminoterminal cysteine residues, these lowmolecular weight proteins signal through G-protein–coupled receptors with seven transmembrane domains[1,2].
Martin Götte, Frank Echtermeyer
openaire   +3 more sources

A Hydrodynamic Bioreactor for High‐Yield Production of Extracellular Vesicles from Stem Cell Spheroids with Defined Cargo Profiling

Advanced Science, EarlyView.
This study harnesses hydrodynamic flows to generate, confine and stimulate stem cell spheroids, enabling the large‐scale production of extracellular vesicles (EVs). This innovative method not only streamlines spheroid formation and subsequent EV release in a single, integrated process, but also ensures the generation of EVs with enhanced biological ...
Solène Lenoir, Elliot Thouvenot, Giacomo Gropplero, Léonie Dec, Damarys Loew, Clotilde Théry, Jose E Perez, Claire Wilhelm   +7 more
wiley   +1 more source

Syndecan-1 Acts as an Important Regulator of CXCL1 Expression and Cellular Interaction of Human Endometrial Stromal and Trophoblast Cells

Mediators of Inflammation, 2017
Successful implantation of the embryo into the human receptive endometrium is substantial for the establishment of a healthy pregnancy. This study focusses on the role of Syndecan-1 at the embryo-maternal interface, the multitasking coreceptor ...
Dunja Maria Baston-Buest, Olga Altergot-Ahmad, Sarah Jean Pour, Jan-Steffen Krüssel, Udo Rudolf Markert, Tanja Natascha Fehm, Alexandra Petra Bielfeld   +6 more
doaj   +1 more source

HSV-1 exploits the innate immune scavenger receptor MARCO to enhance epithelial adsorption and infection [PDF]

, 2014
HSV-1 is an important epithelial pathogen and has the potential for significant morbidity in humans. Here we demonstrate that a cell surface scavenger receptor, macrophage receptor with collagenous structure (MARCO), previously thought to enhance ...
Gallo, Richard L., Kobzik, Lester, MacLeod, Daniel T., Nakatsuji, Teruaki, Yamasaki, Kenshi   +4 more
core   +1 more source

Reduction of syndecan‐1 expression during lip carcinogenesis

Journal of Oral Pathology & Medicine, 2009
Background:  Actinic cheilitis (AC) is an oral pre‐cancerous lesion that sometimes develops into lip squamous cell carcinoma (SCC). Syndecan‐1, a transmembrane heparan sulfate proteoglycan, modulates cell‐proliferation, adhesion, migration and angiogenesis.
Martinez, A., Spencer, M. L., Brethauer, U., Grez, P., Marchesani, F. J., Rojas, I. G.   +5 more
openaire   +4 more sources

Modulating Integrin and Growth Factor Signaling With Peptides: Strategies to Synergistically Enhance Bone Tissue Regeneration

Advanced Science, EarlyView.
It has been demonstrated that, in the bone extracellular matrix (ECM), integrins and growth factor receptors (GFRs) engage in synergistic signaling to guide bone healing and regeneration. This review provides a comprehensive overview of current strategies using ECM‐derived peptides to recreate the cellular microenvironment and harness synergistic ...
Lluís Oliver‐Cervelló, Elisabetta Ada Cavalcanti‐Adam, Carlos Mas‐Moruno   +2 more
wiley   +1 more source

Heparan sulfate mediates trastuzumab effect in breast cancer cells [PDF]

, 2013
Background: Trastuzumab is an antibody widely used in the treatment of breast cancer cases that test positive for the human epidermal growth factor receptor 2 (HER2).
Del Giglio, Auro, Nader, Helena Bonciani, Paredes-Gamero, Edgar Julian, Pinhal, Maria Aparecida Silva, Suarez, Eloah Rabello, Tersariol, Ivarne Luis dos Santos   +5 more
core   +2 more sources