Results 61 to 70 of about 13,926 (184)

Cytosolic Phospholipase A2 Modulates TLR2 Signaling in Synoviocytes

PLOS ONE, 2015
Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic synovitis leading to destruction of cartilage and bone. PLA2 enzymes are key players in inflammation regulating the release of unsaturated fatty acids such as arachidonic acid (AA), a precursor of pro-inflammatory eicosanoids.
Sommerfelt, Randi Magnus, Feuerherm, Astrid Jullumstrø, Skuland, Trine, Johansen, Berit   +3 more
openaire   +5 more sources

Boron Neutron Capture Therapy at a Crossroads: Translational Gap and Emerging Delivery Agents

Chemistry – A European Journal, EarlyView.
This review surveys recent advances in boron delivery agents for BNCT, emphasizing the shift from classical small molecules to multifunctional nanocarriers and theranostic systems. By integrating targeting, imaging, and therapy, next‐generation boron compounds aim to bridge the gap between (bio)chemical innovation and clinical translation.
Christoph Selg, Evamarie Hey‐Hawkins
wiley   +1 more source

IL-26 is overexpressed in rheumatoid arthritis and induces proinflammatory cytokine production and Th17 cell generation. [PDF]

PLoS Biology, 2012
Interleukin-26 (IL-26), a member of the IL-10 cytokine family, induces the production of proinflammatory cytokines by epithelial cells. IL-26 has been also reported overexpressed in Crohn's disease, suggesting that it may be involved in the ...
Murielle Corvaisier, Yves Delneste, Henry Jeanvoine, Laurence Preisser, Simon Blanchard, Erwan Garo, Emmanuel Hoppe, Benjamin Barré, Maurice Audran, Béatrice Bouvard, Jean-Paul Saint-André, Pascale Jeannin   +11 more
doaj   +1 more source

Hepatic fibrosis in patients diagnosed with rheumatoid arthritis and psoriatic arthritis receiving methotrexate: A cross‐sectional analysis using transient elastography

Rheumatology &Autoimmunity, EarlyView.
Hepatic fibrosis and metabolic syndrome are more prevalent in PsA patients treated with methotrexate, compared to RA patients. Metabolic syndrome is associated with the risk of hepatic fibrosis in patients diagnosed with PsA and RA even after adjustment forcumulative methotrexate exposure.
Ratchaya Lertnawapan, Soonthorn Chonprasertsuk, Sith Siramolpiwat, Kanon Jatuworapruk   +3 more
wiley   +1 more source

Ontology and Function of Fibroblast-Like and Macrophage-Like Synoviocytes: How Do They Talk to Each Other and Can They Be Targeted for Rheumatoid Arthritis Therapy?

Frontiers in Immunology, 2018
Fibroblast-like synoviocytes (FLS) and macrophage-like synoviocytes (MLS) are the two main cellular components of the synovium. It has been widely reported that FLS and MLS play essential roles in the joint pathology of rheumatoid arthritis (RA ...
Jiajie Tu, Wenming Hong, Wenming Hong, Pengying Zhang, Xinming Wang, Xinming Wang, Heinrich Körner, Wei Wei   +7 more
doaj   +1 more source

Human infrapatellar fat pad mesenchymal stem cells show immunomodulatory exosomal signatures

Scientific Reports, 2022
Within the human knee infrapatellar fat pad (IFP) and synovium, resident synoviocytes and macrophages contribute to the onset and progression of inflammatory joint diseases.
Dimitrios Kouroupis, Lee D. Kaplan, Thomas M. Best   +2 more
doaj   +1 more source

Mesenchymal stromal cell therapy for rheumatoid arthritis: Long‐term efficacy, safety, and mechanistic insights

Rheumatology &Autoimmunity, EarlyView.
Graphical abstract summarizing the multifactorial pathogenesis of rheumatoid arthritis (RA) and the therapeutic potential of mesenchymal stromal cell (MSC) therapy. MSCs provide promising benefits through their immunomodulatory properties, low immunogenicity, ability to promote tissue repair, and multi‐lineage differentiation, presenting a potential ...
Yingjia Chen, Ruiyu Gao, Xing Guo, Genhong Yao, Xiaojun Tang, Yile E. Liu, Lingyun Sun   +6 more
wiley   +1 more source

Krüppel-Like Factor 4 Is a Regulator of Proinflammatory Signaling in Fibroblast-Like Synoviocytes through Increased IL-6 Expression

Mediators of Inflammation, 2016
Human fibroblast-like synoviocytes play a vital role in joint synovial inflammation in rheumatoid arthritis (RA). Proinflammatory cytokines induce fibroblast-like synoviocyte activation and dysfunction.
Xinjing Luo, Jie Chen, Jianwei Ruan, Yongfeng Chen, Xuanrong Mo, Jiangwen Xie, Guoju Lv   +6 more
doaj   +1 more source

Is the temporomandibular joint affected by rheumatoid arthritis? A comparative investigation with knee arthritis in an experimental rat model

Journal of Anatomy, EarlyView.
Animals were sensitized with mBSA emulsified in CFA/IFA and subsequently received three intra‐articular injections of mBSA into either the TMJ or the knee (once per week). Mechanical hyperalgesia was assessed using electronic von Frey testing after arthritis establishment at 24 h or 7 days following the third intra‐articular injection.
Ana Carolina de Figueiredo Costa, Luane Macedo de Sousa, Delane Viana Gondim   +2 more
wiley   +1 more source

Effect of diclofenac etalhyaluronate (SI-613) on the production of high molecular weight sodium hyaluronate in human synoviocytes

BMC Musculoskeletal Disorders, 2019
Background We have reported that a single intra-articular injection of diclofenac etalhyaluronate (SI-613) exerted a potent and long-lasting analgesic effect in experimental arthritis models.
Tomochika Kisukeda, Junichi Onaya, Keiji Yoshioka   +2 more
doaj   +1 more source