Results 71 to 80 of about 13,926 (184)

Synoviocytes. Autonomous drivers of chronicity?

, 2014
Background: Immunization with Glucose-6-phosphate isomerase (G6PI) induces arthritis in susceptible strains of mice. Depletion of regulatory T cells (Tregs) prior to immunization switches the usually acute, self-limiting course to a non-remitting, destructive arthritis. This provides a possibility to[for full text, please go to the a.m. URL]
Böttcher, M, Schett, G, Falk, C, Irmler, I, Wunrau, C, Korb-Pap, A, Pap, T, Kamradt, T   +7 more
openaire   +2 more sources

Computational modelling of cardiac fibroblast signalling reveals a key role for Ca2+ in driving atrial fibrillation‐associated fibrosis

The Journal of Physiology, EarlyView.
Abstract figure legend A pre‐existing fibroblast signalling model was enhanced by integrating atrial‐specific components and reactions linked to atrial fibrosis and atrial fibrillation (AF). The analysis highlights the central role of Ca2⁺ signalling in driving profibrotic responses to AF‐relevant stimuli, angiotensin‐II and transforming growth factor ...
Najme Khorasani, Haibo Ni, Jeffrey J Saucerman, Dobromir Dobrev, Stefano Morotti, Eleonora Grandi   +5 more
wiley   +1 more source

Hydroxychloroquine potentiates Fas-mediated apoptosis of rheumatoid synoviocytes

Clinical and Experimental Immunology, 2006
SummaryInadequate apoptosis may contribute to the synovial hyperplasia associated with rheumatoid arthritis (RA). The Fas-associated death domain protein (FADD)-like interleukin (IL)-1β-converting enzyme (FLICE)-inhibitory protein (FLIP), which is an apoptotic inhibitor, has been implicated in the resistance to Fas-mediated apoptosis of synoviocytes ...
W-U, Kim, S-A, Yoo, S-Y, Min, S-H, Park, H-S, Koh, S-W, Song, C-S, Cho   +6 more
openaire   +3 more sources

Collagen organisation in the fibrous joint capsules in the digits of the human hand

Journal of Anatomy, Volume 248, Issue 4, Page 612-623, April 2026.
The function of the finger joints is important for daily life. In this review of the literature, we consider the role of collagen and its organization within the fibrous finger joint capsules of the interphalangeal (IP) joints and investigate the relationships between collagen orientation and joint function. Abstract Normal function of the hand and, in
Fiona R. Saunders, Ronald G. Coutts, Richard M. Aspden, Flora Gröning   +3 more
wiley   +1 more source

Senescent Synovial Intimal Fibroblasts Aggravate Osteoarthritis by Regulating Macrophage Polarization and Chondrocyte Phenotype Through ANGPTL4‐α5β1 Axis

Advanced Science, Volume 13, Issue 13, 3 March 2026.
Senescent synovial intimal fibroblasts (SIF) are identified as key drivers of osteoarthritis. They promote M1 macrophage polarization and cartilage degeneration via the ANGPTL4–α5β1 axis, regulated by transcription factors EGR1 and ATF3. Pharmacological inhibition of this pathway alleviates disease, revealing SIF senescence as a promising therapeutic ...
Muhai Deng, Yunsheng Jiang, Zhiyu Chen, Kaiquan Chen, Na Cao, Yang Huang, Zhengxue Quan, Cheng Chen   +7 more
wiley   +1 more source

Signal Transduction of Inflammatory Synoviocytes in Rheumatoid Arthritis

YAKUGAKU ZASSHI, 2008
Recent advances in post-genomic technology enable us to analyze gene expression and protein modification comprehensively in tissues and cells, resulting in new developments in the analysis of molecular events of diseases. We have been studying the pathogenic and progressive mechanisms of diseases from the aspect of signalling pathways of cells ...
Hiroki, Mori, Tohru, Nakanishi
openaire   +3 more sources

Prolonged Release of IL‐10 From Enzyme‐Mediated Poly‐l‐(Tyrosine‐co‐Phenylalanine) Nanocrystals Enhances Stability and Modulates Inflammatory Responses

Biopolymers, Volume 117, Issue 2, March 2026.
Schematic representation of enzyme‐mediated peptide nanocrystal formation and IL‐10 encapsulation, providing stabilized and sustained cytokine delivery that modulates macrophage phenotype and reduces inflammatory responses. ABSTRACT Protease‐catalyzed synthesis of a peptide composed of l‐tyrosine and l‐phenylalanine (2.2:1 M ratio) was achieved in a ...
Fátima Landa‐Tencle, Carmen G. Hernández‐Valencia, Fernando Guzmán‐Lagunes, Carmina Montiel, Yoan Cuellar‐Entenza, Carlos Guerrero‐Sánchez, Steffi Stumpf, Stephanie Hoeppener, Ulrich S. Schubert, Yessica Zamudio‐Cuevas, Roberto Sánchez‐Sánchez, Miquel Gimeno   +11 more
wiley   +1 more source

The Additive Effects of Curcumin Supplementation in Addition to an Anti‐Inflammatory Diet on Inflammatory Indices in Patients With Hashimoto's Thyroiditis (HT): A Double Blind Randomized Controlled Clinical Trial

Food Science &Nutrition, Volume 14, Issue 3, March 2026.
Curcumin supplementation resulted in a reduction in IL‐6. Additionally, it decreased hs‐CRP levels in patients with HT, with a mean reduction of whereas the placebo group exhibited an increase of +1.53 ± 3.33 mg/L (p = 0.305). Also, curcumin supplementation significantly reduced NF‐κB levels in patients with HT, while the placebo group showed a slight ...
Fatemeh Bourbour, Behnam Mahdavi, Niayesh Naghshi, Zahra Yari, Seyedsina Moghimnejad hosseini, Saeid Kalbasi, Golbon Sohrab   +6 more
wiley   +1 more source

Abnormal Expression of DICER1 Leads to Dysregulation of Inflammatory Effectors in Human Synoviocytes

Mediators of Inflammation, 2019
Dysregulation of multiple microRNAs widely takes place during rheumatoid arthritis (RA) and experimental arthritides. This study is performed to explore the possible mechanism underlying DICER1 deficiency-mediated inflammation in human synoviocytes SW982.
Congshan Jiang, Jing Xu, Wenhua Zhu, Yongsong Cai, Si Wang, Yuanxu Guo, Ke Xu, Manman Geng, Nazim Hussain, Yan Han, Fujun Zhang, Qilan Ning, Liesu Meng, Shemin Lu   +13 more
doaj   +1 more source

Kaempferitrin's Dual Assault: Inducing Apoptosis and Ferroptosis in Diffuse Large B‐Cell Lymphoma via NF‐κB Inactivation

The Kaohsiung Journal of Medical Sciences, Volume 42, Issue 3, March 2026.
ABSTRACT Diffuse large B‐cell lymphoma (DLBCL) is the most common non‐Hodgkin lymphoma and is an aggressive and highly heterogeneous tumor. Kaempferitrin (KPF) is a natural flavonoid glycoside that exerts a protective role in multiple human tumors. However, the impact of KPF on DLBCL remains unclear.
Han‐Shuo Zhang, Xiao‐Dan Zhou, Jin Chen, Ling Wang   +3 more
wiley   +1 more source