Results 1 to 10 of about 90,976 (191)

Synthetic flavonoids as novel modulators of platelet function and thrombosis [PDF]

Int J Mol Sci, 2019
Cardiovascular diseases represent a major cause of mortality and morbidity in the world and thrombotic conditions such as heart attacks and strokes are caused by unwarranted activation of platelets and subsequent formation of blood clots (thrombi) within
Dina A. I. Albadawi, Divyashree Ravishankar, Helen M. I. Osborn, Page, Sakthivel Vaiyapuri, Samanta, Thomas M. Vallance, Vlahos   +7 more
core   +6 more sources

Synthetic Biology towards Improved Flavonoid Pharmacokinetics [PDF]

Biomolecules, 2021
Flavonoids are a structurally diverse class of natural products that have been found to have a range of beneficial activities in humans. However, the clinical utilisation of these molecules has been limited due to their low solubility, chemical stability,
Moon Sajid, Chaitanya N. Channakesavula, Shane R. Stone, Parwinder Kaur   +3 more
doaj   +3 more sources

Synthetic flavonoids as potential antiviral agents against SARS-CoV-2 main protease. [PDF]

J Biomol Struct Dyn, 2022
The COVID-19 pandemic has claimed more than a million lives worldwide within a short time span. Due to the unavailability of specific antiviral drugs or vaccine, the infections are causing panic both in general public and among healthcare providers. Therefore, an urgent discovery and development of effective antiviral drug for the treatment of COVID-19
Batool F, Mughal EU, Mughal EU, Zia K, Sadiq A, Naeem N, Javid A, Ul-Haq Z, Saeed M.   +8 more
europepmc   +4 more sources

The Role of Natural and Synthetic Flavonoids in the Prevention of Marine Biofouling [PDF]

Marine Drugs
Marine biofouling is a major concern for the maritime industry, environment, and human health. Biocides which are currently used in marine coatings to prevent this phenomenon are toxic to the marine environment, and therefore a search for antifoulants ...
Daniela Pereira, Madalena Pinto, Joana R. Almeida, Marta Correia-da-Silva, Honorina Cidade   +4 more
doaj   +2 more sources

The Antimicrobial and Cytotoxicity Properties of New Dibrominated 1,3-Dithiolium Flavonoids [PDF]

Pharmaceuticals
Background/Objectives: Antimicrobial resistance (AMR) presents a medical risk as well as a significant global socioeconomic challenge. Key contributors to AMR include the excessive use and incorrect application of antibiotics in humans and agriculture ...
Laura Gabriela Sarbu, Ana Alexandra Dumitru, Mihaela Savu, Isabela Andreea Sandu, Lucian Gabriel Bahrin, Marius Stefan, Mihail Lucian Birsa   +6 more
doaj   +2 more sources

An Improved Synthetic Method for Sensitive Iodine Containing Tricyclic Flavonoids

Molecules, 2022
The synthesis of new iodine containing synthetic tricyclic flavonoids is reported. Due to the sensitivity of the precursors to the heat and acidic conditions required for the ring closure of the 1,3-dithiolium core, a new cyclization method has been ...
Mihail Lucian Birsa, Laura G. Sarbu
doaj   +3 more sources

Antibacterial and Antifungal Properties of New Synthetic Tricyclic Flavonoids

Antibiotics
Background/Objectives: The discovery of new molecules to which bacteria have not yet developed resistance is a significant medical priority. Synthetic flavonoids are good candidates for developing new antimicrobials.
Laura Gabriela Sarbu, Irina Rosca, Mihail Lucian Birsa   +2 more
doaj   +3 more sources

Biochemical evaluation of molecular parts for flavonoid production using plant synthetic biology

Frontiers in Plant Science
Among organisms on Earth, plants have the unique ability to produce a wide variety of biomolecules using soil nutrients, air, and solar energy. Therefore, plants are regarded as the most productive and cost-efficient bioreactors among living organisms ...
Hyo Lee, Saet Buyl Lee, Sangkyu Park, Jaeeun Song, Beom-Gi Kim   +4 more
doaj   +3 more sources

Nephroprotective Effects of Synthetic Flavonoid Hidrosmin in Experimental Diabetic Nephropathy [PDF]

Antioxidants, 2021
Diabetes mellitus (DM) is a high-impact disease commonly characterized by hyperglycemia, inflammation, and oxidative stress. Diabetic nephropathy (DN) is a common diabetic microvascular complication and the leading cause of chronic kidney disease worldwide.
Luna Jiménez-Castilla, Gema Marín-Royo, Macarena Orejudo, Lucas Opazo-Ríos, Teresa Caro-Ordieres, Inés Artaiz, Tatiana Suárez-Cortés, Arturo Zazpe, Gonzalo Hernández, Carmen Gómez-Guerrero, Jesús Egido   +10 more
openaire   +4 more sources

Metabolic Engineering of Microbial Cell Factories for Biosynthesis of Flavonoids: A Review

Molecules, 2021
Flavonoids belong to a class of plant secondary metabolites that have a polyphenol structure. Flavonoids show extensive biological activity, such as antioxidative, anti-inflammatory, anti-mutagenic, anti-cancer, and antibacterial properties, so they are ...
Hanghang Lou, Lifei Hu, Hongyun Lu, Tianyu Wei, Qihe Chen   +4 more
doaj   +1 more source