Results 211 to 220 of about 1,092,864 (243)

Development of a Synthetic Lethality-Based Combination Therapy Using LIG1 and PARP Inhibitors for Prostate Cancer. [PDF]

Cancer Sci
Tani M, Hatano K, Ishizuya Y, Oka T, Kanaki T, Inoguchi S, Yoshimura A, Horibe Y, Liu Y, Nesrine S, Okuda Y, Yamamoto A, Uemura T, Yamamichi G, Hayashi T, Yamamoto Y, Kato T, Kawashima A, Yamaguchi T, Obika S, Yusa K, Nonomura N, Nimura K.   +22 more
europepmc   +1 more source

MetaPaCS: A Novel Meta‐Learning Framework for Pancreatic Cancer Subtype Identification

Advanced Intelligent Systems, EarlyView.
We have developed MetaPaCS, an ensemble meta‐learning framework for reliable prediction of pancreatic cancer subtypes with high accuracy. MetaPaCS is capable of capturing subtype‐specific distinct gene expression patterns and drug‐disease associations for pancreatic cancer.
Nick B. Peterson, Mengtao Sun, Xinchao Wu, Jieqiong Wang, Shibiao Wan   +4 more
wiley   +1 more source

L‐Cysteine and N‐Acetylcysteine Supplementation Improves Clinical Outcome in a Patient With COXPD10

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT MTO1 is a nuclear gene that encodes a mitochondrial protein essential for modifying mitochondrial transfer RNAs (tRNAs) and stabilizing codon‐anticodon interactions to ensure accurate and efficient mitochondrial protein synthesis and oxidative phosphorylation.
Nishitha R. Pillai, Sara A. Elsbecker, Grace Bronken McCarthy, Kaitlin Weisshappel, Peter Karachunski, Fernando Scaglia   +5 more
wiley   +1 more source

Epigenetic synthetic lethality as a cancer therapeutic strategy: synergy of experimental and computational approaches. [PDF]

Epigenomics
Farina-Morillas M, Ollé-Monràs L, Maas SC, de Rojas-P I, Segura MF, Seoane JA.   +5 more
europepmc   +1 more source

Recurrent Neurodevelopmental Disorder Associated With a Dominant‐Negative TOP2B H63Y Variant

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT We describe a 7 year‐old boy with severe neurodevelopmental disorder, medically‐refractory epileptic encephalopathy, hyperkinetic movement disorder, hypotonia, cerebral and cerebellar atrophy and hypomyelination who was found to have a heterozygous de novo TOP2B NM_001330700.2:c.187C>T, p.(His63Tyr) variant.
Zong Yi Ha, Leticia Dinatto, Kirsten Meagher, Colleen Guimond, Jan M. Friedman, Peter C. Stirling, Millan S. Patel   +6 more
wiley   +1 more source

Repurposing clinically safe drugs for DNA repair pathway choice in CRISPR genome editing and synthetic lethality. [PDF]

Nat Commun
Macak D, Kanis P, Riesenberg S.
europepmc   +1 more source

Animal stroke models and outcome evaluation: A review

Animal Models and Experimental Medicine, EarlyView.
Rodents are the preeminent stroke model species. Large animal models exist too, but are poorly standardized. Ischemic and hemorrhagic experimental models are available, with the intraluminal filament model being predominant. Outcomes are evaluated via quantifying subjects' sensorimotor impairment, cognitive memory faculties, degree of cellular ...
Solsa Cariba, Helen M. Atkinson, Anthony K. C. Chan   +2 more
wiley   +1 more source

Synthetic lethality of MCL-1 inhibition and CAR-T therapy in aggressive B-cell lymphoma. [PDF]

Leukemia
Gao J, Zhao X, Yin Q, Hu A, Qiu K, Blackburn L, Lei L, Xiong R, Bi C, Craig JW, Portell CA, Davila ML, Williams ME, Tao J.   +13 more
europepmc   +1 more source

Potent synthetic lethality between PLK1 and EYA family inhibitors in tumors of the central and peripheral nervous systems. [PDF]

Genes Dev
Nelson CB, Wells JK, Kesarwani E, Sobinoff AP, Fernando M, Gao J, MacKenzie KL, Poulos RC, Nawaz U, Wang X, Ford HL, Pickett HA.   +11 more
europepmc   +1 more source

Mutations in tumor signaling, metastases, and synthetic lethality establish distinct patterns. [PDF]

PLoS Comput Biol
Yavuz BR, Sahin U, Jang H, Nussinov R, Tuncbag N.   +4 more
europepmc   +1 more source