Results 211 to 220 of about 43,707 (255)

Exploiting replication stress for synthetic lethality in MYC-driven cancers. [PDF]

Am J Cancer Res
Zhang Y, Ye M, Luan X, Sun Z, Zhang WD.
europepmc   +1 more source

Orchard netting impacts on biodiversity leading to cascading effects at the ecosystem level

Biological Reviews, EarlyView.
ABSTRACT Agriculture must ensure food production without further compromising the ecosystem functions upon which it depends. Agricultural practices should therefore avoid harming farmland biodiversity, especially of taxa that supply the key ecosystem services (e.g.
Corrado Alessandrini, Karan Sethi, Emanuela Granata, Ekaterina Mogilnaia, Valeria Vitangeli, Giovanni Zanfei, Chiara Fedrigotti, Paolo Biella, Dino Scaravelli, Luigi Marchesi, Péter Batáry, Diego Rubolini, Paolo Pedrini, Mattia Brambilla   +13 more
wiley   +1 more source

Benchmarking genetic interaction scoring methods for identifying synthetic lethality from combinatorial CRISPR screens. [PDF]

NAR Genom Bioinform
Ajmal H, Nandi S, Kebabci N, Ryan CJ.
europepmc   +1 more source

Z-scores outperform similar methods for analyzing CRISPR paralog synthetic lethality screens. [PDF]

Genome Biol
Chou J, Esmaeili Anvar N, Elghaish R, Chen J, Hart T.   +4 more
europepmc   +1 more source

Concept of Synthetic Lethality in Cancer

World Journal of Dentistry, 2016
openaire   +1 more source

Targeting RAD51-BRCA2 Interaction to Enhance Synthetic Lethality with Olaparib in Pancreatic Cancer: Development of a Novel Phenyl Furan-Quinoline-Carboxylic Acid Series. [PDF]

ACS Med Chem Lett
Ferrandi G, Bagnolini G, Poppi L, Masi M, Previtali V, Andonaia A, Varignani G, Veronesi M, De Franco F, Falchi F, Di Stefano G, Girotto S, Roberti M, Cavalli A.   +13 more
europepmc   +1 more source

Synthetic lethality of mRNA quality control complexes in cancer. [PDF]

Nature
Prindle V, Richardson AE, Sher KR, Kongpachith S, Kentala K, Petiwala S, Cheng D, Widomski D, Le P, Torrent M, Chen A, Walker S, Palczewski MB, Mitra D, Manaves V, Shi X, Lu C, Sandoval S, Dezso Z, Buchanan FG, Verduzco D, Bierie B, Meulbroek JA, Pappano WN, Plotnik JP.   +24 more
europepmc   +1 more source

The simultaneous targeted Inhibition of ISG15 and HMGCR disrupts cancer stemness through metabolic collapse and induces synthetic lethality in pancreatic ductal adenocarcinoma. [PDF]

J Exp Clin Cancer Res
Sun J, Wang JM, Zhang Q, Lin WY, Tang L, Lu SY, Li BQ, Du ZX, Wang HQ.   +8 more
europepmc   +1 more source

242 The concept of synthetic lethality

European Journal of Cancer Supplements, 2010
openaire   +1 more source

Transposable elements as novel therapeutic targets for PARPi-induced synthetic lethality in PcG-mutated blood cancer.

Blood
Zeisig BB, Tsai CT, Virely C, Fung TK, Akin AT, Troadec E, Jiao B, Thompson IR, Lau PNI, Li N, Charalambous A, Bomfim L, Lynch J, Georgiou A, Hoogeboom R, Lynn C, Zhang SY, Patten PEM, Fisher CL, Schuh A, Ogawa S, Mufti G, Karimi MM, So CWE.   +23 more
europepmc   +1 more source