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Synthetic lethality with cisplatin
Science Signaling, 2018Blocking the kinase MAST1 with lestaurtinib prevents cisplatin resistance in cancers driven by Raf-MEK signaling.
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A lethal combination for cancer cells: Synthetic lethality screenings for drug discovery
European Journal of Cancer, 2010In recent years, cancer drug discovery has faced the challenging task of integrating the huge amount of information coming from the genomic studies with the need of developing highly selective target-based strategies within the context of tumour cells that experience massive genome instability.
E. FERRARI, C. LUCCA, M. FOIANI
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MYC, Metabolic Synthetic Lethality, and Cancer
2016The MYC oncogene plays a pivotal role in the development and progression of human cancers. It encodes a transcription factor that has broad reaching effects on many cellular functions, most importantly in driving cell growth through regulation of genes involved in ribosome biogenesis, metabolism, and cell cycle.
Annie L, Hsieh, Chi V, Dang
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A (synthetic) lethal weapon for cancer
Science Translational Medicine, 2018ROS1 inhibition in E-cadherin–deficient tumors leads to synthetic lethality, which could be exploited for the selective treatment of breast cancer patients.
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Synthetic lethality-mediated precision oncology via the tumor transcriptome
Cell, 2021Joo Sang Lee +2 more
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Comprehensive prediction of robust synthetic lethality between paralog pairs in cancer cell lines
Cell Systems, 2021Barbara De Kegel +2 more
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Capitalizing on Synthetic Lethality of MYC to Treat Cancer in the Digital Age
Trends in Pharmacological Sciences, 2021Dexter Kai Hao Thng +2 more
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Defective ALC1 nucleosome remodeling confers PARPi sensitization and synthetic lethality with HRD
Molecular Cell, 2021Graeme Hewitt +2 more
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