Results 21 to 30 of about 22,875,861 (325)

Advancing Risk Assessment through the Application of Systems Toxicology. [PDF]

Toxicol Res, 2016
Risk assessment is the process of quantifying the probability of a harmful effect to individuals or populations from human activities. Mechanistic approaches to risk assessment have been generally referred to as systems toxicology.
Sauer JM, Kleensang A, Peitsch MC, Hayes AW.   +3 more
europepmc   +2 more sources

Multi-omics systems toxicology study of mouse lung assessing the effects of aerosols from two heat-not-burn tobacco products and cigarette smoke [PDF]

Computational and Structural Biotechnology Journal, 2020
Cigarette smoke (CS) causes adverse health effects and, for smoker who do not quit, modified risk tobacco products (MRTPs) can be an alternative to reduce the risk of developing smoking-related diseases.
Bjoern Titz, Justyna Szostak, Alain Sewer, Blaine Phillips, Catherine Nury, Thomas Schneider, Sophie Dijon, Oksana Lavrynenko, Ashraf Elamin, Emmanuel Guedj, Ee Tsin Wong, Stefan Lebrun, Grégory Vuillaume, Athanasios Kondylis, Sylvain Gubian, Stephane Cano, Patrice Leroy, Brian Keppler, Nikolai V. Ivanov, Patrick Vanscheeuwijck, Florian Martin, Manuel C. Peitsch, Julia Hoeng   +22 more
doaj   +2 more sources

Systems toxicology: from basic research to risk assessment. [PDF]

Chem Res Toxicol, 2014
Systems Toxicology is the integration of classical toxicology with quantitative analysis of large networks of molecular and functional changes occurring across multiple levels of biological organization. Society demands increasingly close scrutiny of the
Sturla SJ, Boobis AR, FitzGerald RE, Hoeng J, Kavlock RJ, Schirmer K, Whelan M, Wilks MF, Peitsch MC.   +8 more
europepmc   +2 more sources

Systems toxicology of chemically induced liver and kidney injuries: histopathology-associated gene co-expression modules. [PDF]

J Appl Toxicol, 2016
Organ injuries caused by environmental chemical exposures or use of pharmaceutical drugs pose a serious health risk that may be difficult to assess because of a lack of non‐invasive diagnostic tests.
Te JA, AbdulHameed MD, Wallqvist A.
europepmc   +2 more sources

Embracing Systems Toxicology at Single-Cell Resolution. [PDF]

Curr Opin Toxicol, 2019
Zhang Q, Caudle WM, Pi J, Bhattacharya S, Andersen ME, Kaminski NE, Conolly RB.   +6 more
europepmc   +2 more sources

Systems Toxicology. [PDF]

EXCLI J, 2015
Ghallab A.
europepmc   +3 more sources

Systems Toxicology of Male Reproductive Development: Profiling 774 Chemicals for Molecular Targets and Adverse Outcomes. [PDF]

Environ Health Perspect, 2016
Background: Trends in male reproductive health have been reported for increased rates of testicular germ cell tumors, low semen quality, cryptorchidism, and hypospadias, which have been associated with prenatal environmental chemical exposure based on ...
Leung MC, Phuong J, Baker NC, Sipes NS, Klinefelter GR, Martin MT, McLaurin KW, Setzer RW, Darney SP, Judson RS, Knudsen TB.   +10 more
europepmc   +2 more sources

Modeling and Simulation of Acetaminophen Pharmacokinetics and Hepatic Biomarkers After Overdoses of Extended-Release and Immediate-Release Formulations in Healthy Adults Using the Quantitative Systems Toxicology Software Platform DILIsym. [PDF]

CPT Pharmacometrics Syst Pharmacol
Beaudoin JJ, Yang K, Howell BA, Kenz Z, Lakhani VV, Woodhead JL, Lai JCK, Gelotte CK, Sista S, Atillasoy E.   +9 more
europepmc   +2 more sources

Quantitative systems toxicology. [PDF]

Curr Opin Toxicol, 2017
Bloomingdale P, Housand C, Apgar JF, Millard BL, Mager DE, Burke JM, Shah DK.   +6 more
europepmc   +2 more sources

A Systems Toxicology-based Approach Reveals Biological Pathways Dysregulated by Prenatal Arsenic Exposure. [PDF]

Ann Glob Health, 2016
Laine JE, Fry RC.
europepmc   +2 more sources