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From Causal Networks to Adverse Outcome Pathways: A Developmental Neurotoxicity Case Study
Frontiers in Toxicology, 2022 The last decade has seen the adverse outcome pathways (AOP) framework become one of the most powerful tools in chemical risk assessment, but the development of new AOPs remains a slow and manually intensive process. Here, we present a faster approach for
Živa Ramšak +5 more
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TOXPANEL: A Gene-Set Analysis Tool to Assess Liver and Kidney Injuries
Frontiers in Pharmacology, 2021 Gene-set analysis is commonly used to identify trends in gene expression when cells, tissues, organs, or organisms are subjected to conditions that differ from those within the normal physiological range.
Patric Schyman +6 more
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Assessing network-based methods in the context of system toxicology
Frontiers in Pharmacology, 2023 Introduction: Network-based methods are promising approaches in systems toxicology because they can be used to predict the effects of drugs and chemicals on health, to elucidate the mode of action of compounds, and to identify biomarkers of toxicity ...
Jordi Valls-Margarit +5 more
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Systems biology meets toxicology [PDF]
Archives of Toxicology, 2012 In this issue of the Archives of Toxicology, Hans Westerhoff and colleagues present a comprehensive review on how systems biology tools can be applied to toxicology (Geenen et al. 2012; this issue). For decades, scientists in the field of toxicology have taken advantage of available mathematical models.
R, Marchan, H M, Bolt, J G, Hengstler
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Predictive Systems Toxicology [PDF]
, 2018 37 pages, 3 figures.
Kiani, Narsis A. +3 more
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ALTEX, 2012 The need for a more mechanistic understanding of the ways in which chemicals modulate biological pathways is urgent if we are to identify and better assess safety issues relating to a wide range of substances developed by the pharmaceutical, chemical, agri-bio, and cosmetic industries.
Thomas, Hartung +5 more
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Systems biology and synthetic biology: A new epoch for toxicology research [PDF]
, 2014 Copyright © 2015 Mark T. Mc Auley et al. This is an open access article distributed under the Creative Commons Attribution License 3.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly ...
Choi, Hyunok +4 more
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Network-Based Methods for Prediction of Drug-Target Interactions
Frontiers in Pharmacology, 2018 Drug-target interaction (DTI) is the basis of drug discovery. However, it is time-consuming and costly to determine DTIs experimentally. Over the past decade, various computational methods were proposed to predict potential DTIs with high efficiency and ...
Zengrui Wu +3 more
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COMPRENDO: Focus and approach [PDF]
, 2006 Tens of thousands of man-made chemicals are in regular use and discharged into the environment. Many of them are known to interfere with the hormonal systems in humans and wildlife.
Axel Allera +35 more
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BAP1 in cancer: epigenetic stability and genome integrity
Discover Oncology, 2022 Mutations in BAP1 have been identified in a hereditary cancer predisposition syndrome and in sporadic tumours. Individuals carrying familiar BAP1 monoallelic mutations display hypersusceptibility to exposure-associated cancers, such as asbestos-driven ...
Sabrina Caporali +2 more
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