Results 131 to 140 of about 17,484,371 (316)

NAD+ protects against EAE by regulating CD4+ T-cell differentiation [PDF]

, 2014
CD4+ T cells are involved in the development of autoimmunity, including multiple sclerosis (MS). Here we show that nicotinamide adenine dinucleotide (NAD+) blocks experimental autoimmune encephalomyelitis (EAE), a mouse model of MS, by inducing immune ...
Arredouani, Mohamed S., Biefer, Hector Rodriguez Cetina, Camacho, Virginia, de la Fuente, Miguel A., Edtinger, Karoline, El Fatimy, Rachid, ElKhal, Abdallah, Ghiran, Ionita, Kissick, Haydn T., Krenzien, Felix, Kuo, Winston P., Li, Suyan, Quante, Markus, Smith, Brian D., Tigges, John C., Toxavidis, Vasilis, Trachtenberg, Alexander J., Tullius, Stefan G., Uehara, Hirofumi, Vasudevan, Anju, Yang, Xiaoyong   +20 more
core   +3 more sources

Eomes cannot replace its paralog T-bet during expansion and differentiation of CD8 effector T cells.

PLoS Pathogens, 2020
The two T-box transcription factors T-bet and Eomesodermin (Eomes) are important regulators of cytotoxic lymphocytes (CTLs), such as activated CD8 T cells, which are essential in the fight against intracellular pathogens and tumors.
Jonas Fixemer, Jonas F Hummel, Frederic Arnold, Christoph S N Klose, Alexis Hofherr, Kristoffer Weissert, Tamara Kögl, Michael Köttgen, Sebastian J Arnold, Peter Aichele, Yakup Tanriver   +10 more
doaj   +1 more source

Improved Outcomes for Older Children, Adolescents, and Young Adults With Neuroblastoma in the Post‐Immunotherapy Era: An Updated Report From the International Neuroblastoma Risk Group

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background We describe clinical and biologic characteristics of neuroblastoma in older children, adolescents, and young adults (OCAYA); describe survival outcomes in the post‐immunotherapy era; and identify if there is an age cut‐off that best discriminates outcomes.
Rebecca J. Deyell, Kavitha Srivatsa, Paola Angelini, Pei‐Chi Kao, Brady Payne, Arlene Naranjo, Sveva Castelli, Miho Kato, Miki Ohira, Ulriche Pöetschger, Yaël Mossé, Lucas Moreno, Meredith S. Irwin, Ramya Ramanujachar, Wendy B. London   +14 more
wiley   +1 more source

Chronic viral infection promotes sustained Th1-derived immunoregulatory IL-10 via BLIMP-1 [PDF]

, 2014
During the course of many chronic viral infections, the antiviral T cell response becomes attenuated through a process that is regulated in part by the host. While elevated expression of the immunosuppressive cytokine IL-10 is involved in the suppression
Brüstle, Anne, Chen, Jonathan H, Cui, Weiguo, Kaech, Susan M, Laidlaw, Brian J, Lang, Philipp A, Marshall, Heather D, Ohashi, Pamela, Parish, Ian A, Perry, Curtis, Staron, Matthew M, Tsui, Yao-Chen, Weaver, Casey T   +12 more
core   +1 more source

Siah2 control of T-regulatory cells limits anti-tumor immunity. [PDF]

, 2020
Understanding the mechanisms underlying anti-tumor immunity is pivotal for improving immune-based cancer therapies. Here, we report that growth of BRAF-mutant melanoma cells is inhibited, up to complete rejection, in Siah2-/- mice.
Aifantis, Ioannis, Bosenberg, Marcus, Bradley, Linda M, Brown, Kevin, Dolgalev, Igor, Feng, Yongmei, Hockemeyer, Kathryn, Li, Yan, Marine, Jean-Christophe, Otero, Dennis C, Poźniak, Joanna, Rambow, Florian, Ronai, Ze'ev A, Scortegagna, Marzia, Tinoco, Roberto, Zhang, Tongwu   +15 more
core   +2 more sources

Transcription factor T-bet in Atlantic salmon: Characterization and gene expression in mucosal tissues during Aeromonas salmonicida infection

Frontiers in Immunology, 2015
The T-box transcription factor T-bet is expressed in a number of hematopoietic cell types in mammals and plays an essential role in the lineage determination of Th1 T-helper cells and is considered as an essential feature for both innate and adaptive ...
Jaya eKumari, Jaya eKumari, Zuobing eZhang, Zuobing eZhang, Trilochan eSwain, Heng eChi, Heng eChi, Cuijuan eNiu, Jarl eBøgwald, Roy Ambli Dalmo   +9 more
doaj   +1 more source

Overexpression of T-bet, GATA-3 and TGF-ß Induces IFN-γ, IL-4/13A, and IL-17A Expression in Atlantic Salmon

Biology, 2020
The overexpression of GATA-3, T-bet and TGF-ß may theoretically induce IL-4/A, IFN-γ and IL-17A expression, respectively. Whether this also applies to fish is not yet known.
Tiril H. Slettjord, Hege J. Sekkenes, Heng Chi, Jarl Bøgwald, Trilochan Swain, Roy A. Dalmo, Jaya Kumari Swain   +6 more
doaj   +1 more source

Patient‐Level Barriers and Facilitators to Inpatient Physical Therapy in Adolescents and Young Adults With a Hematological Malignancy: A Qualitative Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Despite their increased risk for functional impairment resulting from cancer and its treatments, few adolescents and young adults (AYAs) with a hematological malignancy receive the recommended or therapeutic dose of exercise per week during inpatient hospitalizations.
Jennifer A. Kelleher, Jennifer L. Bernstein, Katia M. Crisler, Julia K. Herriott, Kimberly L. Klages, Robin E. Norris, Mariann L. Strenk, Sarah E. Bills, Meghan E. McGrady   +8 more
wiley   +1 more source

携带T-bet基因的重组腺病毒载体的构建

Zhongguo shiyan zhenduanxue, 2008
目的包装携带人T细胞转录因子T-bet基因的重组腺病毒,为研究T-bet在人鼻黏膜中作用的分子机制奠定基础。方法采用RT-PCR方法从健康人PBMC中扩增出转录因子T-bet的cDNA序列,构建重组穿梭载体pDC316-T-bet;采用阳离子脂质体介导将重组穿梭载体pDC316 T-bet与pBHGloxΔE1,3C re质粒共转染293细胞,包装出携带T-bet基因的重组腺病毒rAdT-bet,空斑纯化,PCR鉴定阳性rAdT-bet。结果以空斑纯化后的rAdT-bet为模板 ...
孙克巍, 朱学伟, 朱武飞, 朱冬冬, 董震   +4 more
doaj  

T-bet Transcendent: Unmasking the Faces of Multifarious Immunity [PDF]

The Journal of Immunology, 2015
We dwell in an environment filled with germs of different sizes and lifestyles. In response, we have evolved a sophisticated system of host defense that can recognize nearly limitless antigenic shapes.
openaire   +2 more sources