Results 1 to 10 of about 28,724 (145)

Downregulation of Transcription Factor T-Bet as a Protective Strategy in Monosodium Urate-Induced Gouty Inflammation [PDF]

Frontiers in Immunology, 2019
Gout is sterile joint inflammation triggered by the damaging effects of monosodium urate (MSU) crystals accumulation. Previous studies suggest transcription factor T-bet plays an important role in inflammatory arthritis.
Qi-Bin Yang, Yong-Long He, Yong-Long He, Quan-Bo Zhang, Qing-Sheng Mi, Jing-Guo Zhou   +5 more
doaj   +3 more sources

Stable characteristics of intrapopulation heterogeneity in virus-specific Th1 cells during chronic viral challenge infection [PDF]

Frontiers in Immunology
Virus-specific CD4+ T cells typically undergo T helper (Th) 1 differentiation and contribute to a type 1 immune response in infection with lymphocytic choriomeningitis virus (LCMV).
Valerie Plajer, Valerie Plajer, Adrián Madrigal-Avilés, Adrián Madrigal-Avilés, Maria Dzamukova, Maria Dzamukova, Nayar Durán-Hernández, Nayar Durán-Hernández, Philippe Saikali, Philippe Saikali, Vivien Holecska, Vivien Holecska, Isabel Panse, Isabel Panse, Katrin Lehmann, Jinfang Zhu, Mir-Farzin Mashreghi, Mir-Farzin Mashreghi, Ahmed N. Hegazy, Ahmed N. Hegazy, Caroline Peine, Caroline Peine, Max Löhning, Max Löhning   +23 more
doaj   +2 more sources

Identification of the T-box transcription factor t-bet in chickens and its role in immune response [PDF]

Poultry Science
T-bet (T-box transcription factor TBX21), encoded by the Tbx21 gene, is a key regulator of T helper 1 (Th1) cell differentiation and cellular immunity. However, the role of T-bet in avian species remains elusive. To investigate the role of T-bet in avian
Yuxin Guo, Zhaocan Zhou, Hui Gao, Shujun Zhang, Zhi Chen, He Chang, Hong Cao, Li Gao, Yongqiang Wang, Shijun J. Zheng   +9 more
doaj   +2 more sources

T-helper Cell Type-1 Transcription Factor T-Bet Is Down-regulated in Type 1 Diabetes

Iranian Journal of Allergy, Asthma and Immunology, 2016
T cells have been identified as key players in the pathogenesis of type 1 diabetes. However, the exact role of T-cell subpopulations in this pathway is presently unknown.
Hajar Vaseghi, Mohammad Hossein Sanati, Zohreh Jadali   +2 more
doaj   +2 more sources

Identification and Characterization of a Master Transcription Factor of Th1 Cells, T-bet, Within Flounder (Paralichthys olivaceus)

Frontiers in Immunology, 2021
T-bet, a T-box family member, is a transcription factor essential for the differentiation of naive CD4+ T cells into Th1 cells that are involved in both innate and adaptive immune responses.
Hongfei Tian, Jing Xing, Jing Xing, Xiaoqian Tang, Xiaoqian Tang, Heng Chi, Xiuzhen Sheng, Wenbin Zhan, Wenbin Zhan   +8 more
doaj   +1 more source

Transcription Factor T-bet Regulates Intraepithelial Lymphocyte Functional Maturation [PDF]

Immunity, 2014
The intestinal epithelium harbors large populations of activated and memory lymphocytes, yet these cells do not cause tissue damage in the steady state. We investigated how intestinal T cell effector differentiation is regulated upon migration to the intestinal epithelium. Using gene loss- and gain-of-function strategies, as well as reporter approaches,
Reis, Bernardo S., Hoytema van Konijnenburg, David P., Grivennikov, Sergei I., Mucida, Daniel   +3 more
openaire   +2 more sources

The immune cell transcription factor T-bet [PDF]

Adipocyte, 2013
Obesity-associated insulin resistance is accompanied by an alteration in the Th1/Th2 balance in adipose tissue. T-bet (Tbx21) is an immune cell transcription factor originally described as the master regulator of Th1 cell development, although is now recognized to have a role in both the adaptive and innate immune systems.
Stolarczyk, Emilie, Lord, Graham, Howard, Jane   +2 more
openaire   +4 more sources

A Novel Transcription Factor, T-bet, Directs Th1 Lineage Commitment [PDF]

Cell, 2000
Naive T helper cells differentiate into two subsets, Th1 and Th2, each with distinct functions and cytokine profiles. Here, we report the isolation of T-bet, a Th1-specific T box transcription factor that controls the expression of the hallmark Th1 cytokine, IFNgamma. T-bet expression correlates with IFNgamma expression in Th1 and NK cells.
Szabo, Susanne J, Kim, Sean T, Costa, Gina L, Zhang, Xiankui, Fathman, C.Garrison, Glimcher, Laurie H   +5 more
openaire   +2 more sources

T‐bet, a Th1 transcription factor regulates the expression of Tim‐3 [PDF]

European Journal of Immunology, 2010
AbstractT‐cell immunoglobulin, mucin domain‐3 (Tim‐3) is a membrane protein expressed at late stages of IFN‐γ secreting CD4+ Th1 cell differentiation and constitutively on DC. Ligation of Tim‐3 on Th1 cells terminates Th1 immune responses. In addition, Tim‐3 plays a role in tolerance induction, although the mechanism by which this is accomplished has ...
Anderson, Ana C, Lord, Graham M, Dardalhon, Valerie, Lee, David H, Sabatos-Peyton, Catherine A, Glimcher, Laurie H, Kuchroo, Vijay K   +6 more
openaire   +3 more sources

IL-21 Promotes CD8+ CTL Activity via the Transcription Factor T-bet [PDF]

The Journal of Immunology, 2013
Abstract CD8+ T cells are fundamental for immune-mediated clearance of viral infections and contribute to immune pathology in autoimmune diseases such as type 1 diabetes. To execute these functions, CD8+ T cells must differentiate into CTLs, a process that is precisely regulated by a variety of cytokines, costimulatory molecules, and ...
Andrew P R, Sutherland, Nicole, Joller, Monia, Michaud, Sue M, Liu, Vijay K, Kuchroo, Michael J, Grusby   +5 more
openaire   +2 more sources