Results 11 to 20 of about 79,077 (284)

Genetic variants alter T-bet binding and gene expression in mucosal inflammatory disease. [PDF]

PLoS Genetics, 2017
The polarization of CD4+ T cells into distinct T helper cell lineages is essential for protective immunity against infection, but aberrant T cell polarization can cause autoimmunity.
Katrina Soderquest, Arnulf Hertweck, Claudia Giambartolomei, Claudia Giambartolomei, Stephen Henderson, Rami Mohamed, Rimma Goldberg, Esperanza Perucha, Lude Franke, Javier Herrero, Vincent Plagnol, Richard G Jenner, Graham M Lord   +12 more
doaj   +19 more sources

Clinical significance of T-bet, GATA-3, and Bcl-6 transcription factor expression in bladder carcinoma [PDF]

Journal of Translational Medicine, 2016
The aim of this study was to investigate the clinical significance of three immune cell-related transcription factors, T-bet, GATA-3 and Bcl-6 in bladder cancer in Tunisian patients.Expression of T-bet, GATA-3 and Bcl-6 genes was assessed using RT-qPCR in 65 bladder cancers from patients: 32 being diagnosed as low- and medium-grade, 31 as high-grade ...
Islem Ben Bahria-Sediki, Nadhir Yousfi, Catherine Paul, Mohamed Chébil, M. Chérif, Rachida Zermani, Amel Ben Ammar El Gaaied, Ali Bettaieb   +7 more
openaire   +7 more sources

B cells expressing the transcription factor T-bet drive lupus-like autoimmunity [PDF]

Journal of Clinical Investigation, 2017
B cells contribute to multiple aspects of autoimmune disorders and may play a role in triggering disease. Thus, targeting B cells may be a promising strategy for treating autoimmune disorders. Better understanding of the B cell subsets that are responsible for the development of autoimmunity will be critical for developing efficient therapies.
Kira, Rubtsova, Anatoly V, Rubtsov, Joshua M, Thurman, Johanna M, Mennona, John W, Kappler, Philippa, Marrack   +5 more
openaire   +2 more sources

T-bet syndrome-associated bronchial asthma phenotype

Медицинская иммунология, 2020
We aimed to evaluate a significance of T-bet transcription factor in bronchial asthma (BA). A total of 102 patients with BA were examined. The control group was represented by healthy subjects (21 people).
L. N. Sorokina, V. N. Mineev, A. V. Eremeeva, M. A. Nyoma   +3 more
doaj   +1 more source

A genetic method specifically delineates Th1-type Treg cells and their roles in tumor immunity

Cell Reports, 2023
Summary: Regulatory T (Treg) cells expressing the transcription factor (TF) Foxp3 also express other TFs shared by T helper (Th) subsets under certain conditions.
Masaaki Okamoto, Miwa Sasai, Ayumi Kuratani, Daisuke Okuzaki, Masaya Arai, James B. Wing, Shimon Sakaguchi, Masahiro Yamamoto   +7 more
doaj   +1 more source

Expression Regulation and Function of T-Bet in NK Cells

Frontiers in Immunology, 2021
Natural killer (NK) cells are cytotoxic innate lymphocytes that play an important role in immune surveillance. The development, maturation and effector functions of NK cells are orchestrated by the T-box transcription factor T-bet, whose expression is ...
Chen Huang, Jiacheng Bi
doaj   +1 more source

Endothelial injury in transplant glomerulopathy is correlated with transcription factor T-bet expression [PDF]

Kidney International, 2012
Transplant glomerulopathy is an important cause of late graft loss. Inflammatory lesions including glomerulitis and peritubular capillaritis, suggestive of endothelial injury, are prominent in this condition but the mechanism underlying this inflammation remains unclear.
Sun, Qiquan, Zhang, Mingchao, Xie, Kenan, Li, Xue, Zeng, Caihong, Zhou, Minlin, Liu, Zhihong   +6 more
openaire   +2 more sources

CpG and Interleukin-15 Synergize to Enhance IFN-γ Production by Activated CD8+ T Cells [PDF]

, 2012
Interleukin-15 (IL-15) regulates the development and maintenance of memory CD8+ T cells. Paradoxically, we previously reported that IL-15 could enhance CD8+ T-cell responses to IL-12, a proinflammatory cytokine required for optimal priming of effector ...
Cobb, Dustin, Guo, Siqi, Smeltz, Ronald B.   +2 more
core   +7 more sources

Eomes is sufficient to regulate IL-10 expression and cytotoxic effector molecules in murine CD4+ T cells

Frontiers in Immunology, 2023
The T-box transcription factors T-bet and Eomesodermin regulate type 1 immune responses in innate and adaptive lymphocytes. T-bet is widely expressed in the immune system but was initially identified as the lineage-specifying transcription factor of Th1 ...
Benedikt Thelen, Vincent Schipperges, Paulina Knörlein, Jonas F. Hummel, Frederic Arnold, Frederic Arnold, Frederic Arnold, Laurence Kupferschmid, Christoph S. N. Klose, Sebastian J. Arnold, Sebastian J. Arnold, Melanie Boerries, Melanie Boerries, Yakup Tanriver, Yakup Tanriver   +14 more
doaj   +1 more source

Transcription factor T-bet regulates inflammatory arthritis through its function in dendritic cells [PDF]

Journal of Clinical Investigation, 2006
The transcription factor T-bet (Tbx21) plays a major role in adaptive immunity and is required for optimal IFN-gamma production by DCs. Here we demonstrate an essential function for T-bet in DCs in controlling inflammatory arthritis. We show that collagen antibody-induced arthritis (CAIA), a model of human RA, is a bipartite disease characterized by an
Jingsong, Wang, John W, Fathman, Geanncarlo, Lugo-Villarino, Lucila, Scimone, Ulrich, von Andrian, David M, Dorfman, Laurie H, Glimcher   +6 more
openaire   +2 more sources