Results 31 to 40 of about 79,077 (284)

Characterization of T-bet and eomes in peripheral human immune cells. [PDF]

, 2014
The T-box transcription factors T-bet and Eomesodermin (Eomes) have been well defined as key drivers of immune cell development and cytolytic function. While the majority of studies have defined the roles of these factors in the context of murine T-cells,
Betts, Michael R., Cosma, Gabriela L., Knox, James J., McLane, Laura M.   +3 more
core   +3 more sources

T-bet Activates Th1 Genes through Mediator and the Super Elongation Complex

Cell Reports, 2016
The transcription factor T-bet directs Th1 cell differentiation, but the molecular mechanisms that underlie this lineage-specific gene regulation are not completely understood.
Arnulf Hertweck, Catherine M. Evans, Malihe Eskandarpour, Jonathan C.H. Lau, Kristine Oleinika, Ian Jackson, Audrey Kelly, John Ambrose, Peter Adamson, David J. Cousins, Paul Lavender, Virginia L. Calder, Graham M. Lord, Richard G. Jenner   +13 more
doaj   +1 more source

Increased bleomycin-induced lung injury in mice deficient in the transcription factor T-bet [PDF]

American Journal of Physiology-Lung Cellular and Molecular Physiology, 2006
The reasons for variable sensitivity among and within species to lung injury and fibrosis caused by bleomycin (BLM) are unknown. Because T helper (Th) 1 and 2 (Th1 and Th2) polarization of CD4+T lymphocytes is one of the factors that affects the BLM response, we hypothesized that preventing expression of the Th1 transcription factor T-bet would render ...
Jianguo, Xu, Ana L, Mora, John, LaVoy, Kenneth L, Brigham, Mauricio, Rojas   +4 more
openaire   +2 more sources

T-bet controls severity of hypersensitivity pneumonitis [PDF]

, 2011
Hypersensitivity Pneumonitis (HP) is an interstitial lung disease that develops following repeated exposure to inhaled environmental antigens. The disease is characterized by alveolitis, granuloma formation and in some patients' fibrosis.
Elizabeth A Fitzpatrick, Hossam Abdelsamed, Meena Desai, Stephanie C Nance   +3 more
core   +2 more sources

T-bet is a key modulator of IL-23-driven pathogenic CD4+ T cell responses in the intestine

Nature Communications, 2016
How transcription factor T-bet and Th17 cells contribute to colitis remains incompletely understood. Here the authors identify T-bet as a negative regulator of IL-23R pathway activation and show that T-bet deficient T cells drive colitogenic Th17 ...
Thomas Krausgruber, Chris Schiering, Krista Adelmann, Oliver J. Harrison, Agnieszka Chomka, Claire Pearson, Philip P. Ahern, Matthew Shale, Mohamed Oukka, Fiona Powrie   +9 more
doaj   +1 more source

The effect of glatiramer acetate, IFNβ-1a, fingolimod, and dimethyl fumarate on the expression of T-bet, IFN-γ, and MEG3 in PBMC of RRMS patients

BMC Research Notes, 2023
Objective Multiple sclerosis (MS) is a progressing neurodegenerative disease marked by chronic central nervous system inflammation and degeneration.This study investigates gene expression profiles of T-box transcription factor TBX21 (T-bet), interferon ...
Rozhin Dabbaghi, Reza Safaralizadeh, Shima Rahmani, Nesa Barpour, Mohammadali Hosseinpourfeizi, Ali Rajabi, Behzad Baradaran   +6 more
doaj   +1 more source

Targeting the epigenetic readers in Ewing Sarcoma inhibits the oncogenic transcription factor EWS/Fli1. [PDF]

, 2016
Ewing Sarcoma is a rare bone and soft tissue malignancy affecting children and young adults. Chromosomal translocations in this cancer produce fusion oncogenes as characteristic molecular signatures of the disease.
Alonso, Alonso, Bhalla, Chicas, Conway, Delattre, Delattre, Denny, Denny, Figg, Ghysdael, Gibson, Helman, Helman, Ilaria, Iwamoto, Iwamoto, Iwamoto, James, Janknecht, Juergens, Jurgens, Kees, Kim, Kim, Kimura, Komori, Kovar, Kovar, Kung, Lee, Lee, Lessnick, Lieb, Lugo, May, May, McKeown, McKeown, Notario, Ory, Rausen, Richter, Rouleau, Staege, Stein, Takei, Toretsky, Triche, Umezawa, Uren, Uren, van den Berg, Young, Young, Young, Zhou   +56 more
core   +2 more sources

c-Myb Regulates the T-Bet-Dependent Differentiation Program in B Cells to Coordinate Antibody Responses

Cell Reports, 2017
Summary: Humoral immune responses are tailored to the invading pathogen through regulation of key transcription factors and their networks. This is critical to establishing effective antibody-mediated responses, yet it is unknown how B cells integrate ...
Dana Piovesan, Jessica Tempany, Andrea Di Pietro, Inge Baas, Callisthenis Yiannis, Kristy O’Donnell, Yunshun Chen, Victor Peperzak, Gabrielle T. Belz, Charles R. Mackay, Gordon K. Smyth, Joanna R. Groom, David M. Tarlinton, Kim L. Good-Jacobson   +13 more
doaj   +1 more source

Chromatin Remodeling Protein SMAR1 Is a Critical Regulator of T Helper Cell Differentiation and Inflammatory Diseases [PDF]

, 2017
T cell differentiation from naïve T cells to specialized effector subsets of mature cells is determined by the iterative action of transcription factors.
Agarwal, Ahlfors, Ano, Arvey, Bailis, Balasubramani, Battaglia, Bettelli, Beyer, Bhardwaj, Cai, Cao, Chattopadhyay, Chattopadhyay, Chaudhry, Chaudhry, Chemmannur, Chemmannur, Chen, Choi, Dang, Delgoffe, Eivazova, Eivazova, Fang, Farh, Fontenot, Fransson, Fraser, Grogan, Hori, Hübner, Jain, Kanhere, Karantanos, Kasper, Kaul-Ghanekar, Kaul-Ghanekar, Kim, Kitagawa, Komatsu, Kondo, Kumaran, Lam, Laurence, Lazarevic, Le Friec, Lee, Lee, Lei, Li, Li, Limbach, Lohoff, Martin, Maruyama, Mayne, Minter, Mirlekar, Mirlekar, Mirlekar, Miyazaki, Munthe-Kaas, Murugaiyan, Nakka, Ndifon, Oldenhove, Osorio, Oswald, Ouyang, Peer, Peng, Peterson, Quirion, Rampalli, Rekvig, Rengarajan, Rothenberg, Salas, Samstein, Sauer, Schones, Sekimata, Shaw, Shih, Simeoni, Sinha, Spilianakis, Sreenath, Stienne, Szabo, Tanaka, Tone, Uddin, Vanvalkenburgh, Varma, Vignali, Wan, Wang, Wang, Wang, Wang, Wei, Wilson, Wong, Xu, Xu, Yang, Yang, Yong, Yoshida, Zhang, Zhang, Zheng, Zhou, Zhu, Zhu, Zhu   +117 more
core   +3 more sources

Higher Numbers of T-Bet+ Tumor-Infiltrating Lymphocytes Associate with Better Survival in Human Epithelial Ovarian Cancer

Cellular Physiology and Biochemistry, 2017
Background/Aims: T-bet, a member of the T-box family of transcription factors, is a key marker of type I immune response within the tumor microenvironment, and has been previously reported by us to serve as an important prognostic indicator for human ...
Yun Xu, Lujun Chen, Bin Xu, Yuqi Xiong, Min Yang, Xiaohui Rui, Liangrong Shi, Changping Wu, Jingting Jiang, Binfeng Lu   +9 more
doaj   +1 more source