Results 41 to 50 of about 79,077 (284)

Erratum: Corrigendum: Stability and function of regulatory T cells expressing the transcription factor T-bet [PDF]

Nature, 2017
This corrects the article DOI: 10.1038/nature22360.
Andrew G, Levine, Alejandra, Mendoza, Saskia, Hemmers, Bruno, Moltedo, Rachel E, Niec, Michail, Schizas, Beatrice E, Hoyos, Ekaterina V, Putintseva, Ashutosh, Chaudhry, Stanislav, Dikiy, Sho, Fujisawa, Dmitriy M, Chudakov, Piper M, Treuting, Alexander Y, Rudensky   +13 more
openaire   +2 more sources

Subset- and tissue-defined STAT5 thresholds control homeostasis and function of innate lymphoid cells [PDF]

, 2016
Innate lymphoid cells (ILCs) patrol environmental interfaces to defend against infection and protect barrier integrity. Using a genetic tuning model, we demonstrate that the signal-dependent transcription factor (TF) STAT5 is critical for accumulation of
Villarino, Alejandro V^, Sciumè, Giuseppe^, Davis, Fred P, Iwata, Shigeru, Zitti, Beatrice, Robinson, Gertraud W, Hennighausen, Lothar, Kanno, Yuka, O'Shea, John J, ^Co-Firs, T.   +9 more
core   +1 more source

The Role of Protein Modifications of T-Bet in Cytokine Production and Differentiation of T Helper Cells

Journal of Immunology Research, 2014
T-Bet (T-box protein expressed in T cells, also called as TBX21) was originally cloned as a key transcription factor involved in the commitment of T helper (Th) cells to the Th1 lineage.
Sera Oh, Eun Sook Hwang
doaj   +1 more source

The Transcription Factors T-bet and Eomes Control Key Checkpoints of Natural Killer Cell Maturation [PDF]

Immunity, 2012
Natural killer (NK) cells play critical roles defending against tumors and pathogens. We show that mice lacking both transcription factors Eomesodermin (Eomes) and T-bet failed to develop NK cells. Developmental stability of immature NK cells constitutively expressing the death ligand TRAIL depended on T-bet.
Gordon, Scott M., Chaix, Julie, Rupp, Levi J., Wu, Junmin, Madera, Sharline, Sun, Joseph C., Lindsten, Tullia, Reiner, Steven L.   +7 more
openaire   +2 more sources

Correlation Network Analysis Reveals Relationships between MicroRNAs, Transcription Factor T-bet, and Deregulated Cytokine/Chemokine-Receptor Network in Pulmonary Sarcoidosis

Mediators of Inflammation, 2015
Sarcoidosis is an inflammatory granulomatous disease with unknown etiology driven by cytokines and chemokines. There is limited information regarding the regulation of cytokine/chemokine-receptor network in bronchoalveolar lavage (BAL) cells in pulmonary
Tereza Dyskova, Regina Fillerova, Tomas Novosad, Milos Kudelka, Monika Zurkova, Petr Gajdos, Vitezslav Kolek, Eva Kriegova   +7 more
doaj   +1 more source

The Transcription Factor T-Bet Is Regulated by MicroRNA-155 in Murine Anti-Viral CD8+ T Cells via SHIP-1

Frontiers in Immunology, 2017
We report here that the expression of the transcription factor T-bet, which is known to be required for effector cytotoxic CD8+ T lymphocytes (CTL) generation and effector memory cell formation, is regulated in CTL by microRNA-155 (miR-155). Importantly,
Jennifer L. Hope, Jennifer L. Hope, Christopher J. Stairiker, Christopher J. Stairiker, Panagiota I. Spantidea, Donald T. Gracias, Alison J. Carey, Alison J. Carey, Adam J. Fike, Marjan van Meurs, Inge Brouwers-Haspels, Laurine C. Rijsbergen, Joseph A. Fraietta, Yvonne M. Mueller, Rosemarieke C. Klop, Erietta Stelekati, E. John Wherry, Stefan J. Erkeland, Peter D. Katsikis   +18 more
doaj   +1 more source

T-bet-dependent ILC1- and NK cell-derived IFN-γ mediates cDC1-dependent host resistance against Toxoplasma gondii.

PLoS Pathogens, 2021
Host resistance against intracellular pathogens requires a rapid IFN-γ mediated immune response. We reveal that T-bet-dependent production of IFN-γ is essential for the maintenance of inflammatory DCs at the site of infection with a common protozoan ...
Américo H López-Yglesias, Elise Burger, Ellie Camanzo, Andrew T Martin, Alessandra M Araujo, Samantha F Kwok, Felix Yarovinsky   +6 more
doaj   +1 more source

T-Bet Deficiency Attenuates Bile Duct Injury in Experimental Biliary Atresia

Cells, 2021
Biliary atresia (BA) is an obstructive neonatal cholangiopathy leading to liver cirrhosis and end stage liver disease. A Kasai portoenterostomy may restore biliary drainage, but most patients ultimately require liver transplantation for survival.
Sujit K. Mohanty, Bryan Donnelly, Haley Temple, Alexander Bondoc, Monica McNeal, Greg Tiao   +5 more
doaj   +1 more source

Predominance of weakly cytotoxic, T-betLowEomesNeg CD8+ T-cells in human gastrointestinal mucosa: implications for HIV infection. [PDF]

, 2017
The gastrointestinal mucosa is an important site of HIV acquisition, viral replication, and pathogenesis. Immune cells in mucosal tissues frequently differ in phenotype and function from their non-mucosal counterparts.
Critchfield, JW, Deeks, SG, Ganesh, A, Hecht, FM, Hunt, PW, Kiniry, BE, Shacklett, BL, Somsouk, M   +7 more
core   +1 more source

Transcription factor T-bet in Atlantic salmon: Characterization and gene expression in mucosal tissues during Aeromonas salmonicida infection

Frontiers in Immunology, 2015
The T-box transcription factor T-bet is expressed in a number of hematopoietic cell types in mammals and plays an essential role in the lineage determination of Th1 T-helper cells and is considered as an essential feature for both innate and adaptive ...
Jaya eKumari, Jaya eKumari, Zuobing eZhang, Zuobing eZhang, Trilochan eSwain, Heng eChi, Heng eChi, Cuijuan eNiu, Jarl eBøgwald, Roy Ambli Dalmo   +9 more
doaj   +1 more source