Results 121 to 130 of about 15,323,666 (293)
Advanced Science, EarlyView.A phosphorus‐modified single‐atom copper nanozyme delivering the IDO1 inhibitor 1‐methyl‐tryptophan enhances breast cancer radioimmunotherapy by simultaneously relieving hypoxia and inducing immunogenic cell death through dual enzyme activities while blocking tryptophan metabolism to suppress regulatory T cell function.
Wei Zhao +11 more
wiley +1 more source
Smart Nanotechnologies for Multimodal Neuromodulation and Brain Interfacing
Advanced Science, EarlyView.Recent advances in smart nanotechnologies are expanding the toolbox for brain interfacing, from wireless neuromodulation and high‐resolution sensing to targeted delivery within the central nervous system. By combining responsive nanomaterials with bioinspired design, these platforms enable multimodal interactions with neurons and glia, while also ...
Tommaso Curiale +6 more
wiley +1 more source
Epigenetic Determinants of CD8+ T Cell Exhaustion
, 2019 T cell exhaustion describes an acquired dysfunction common in settings of chronic viral infection. Despite clinical efforts to rescue exhaustion, the fundamental mechanisms specifying this state, and the potential for reprogramming exhausted T cells ...
Sen, Debattama R.
core +1 more source
Flexoelectricity in Photoconversion: Fundamentals, Materials, and Outlooks
Advanced Science, EarlyView.Mechanical bending of a flexible cantilever induces a strain gradient in the photoactive material. The resulting flexoelectric field couples with photovoltaic and photoconductive effects, modulating charge generation, separation, and collection. A comparative analysis of oxide perovskites, halide perovskites, and two‐dimensional materials is presented,
Xiang Huang, Feng Li, Rongkun Zheng
wiley +1 more source
Advanced Science, EarlyView.Technical limitations often let dominant signals overshadow rare cell types and fine‐grained heterogeneity in spatial transcriptomics. SemanticST, a graph neural network using multi‐semantic graph fusion and a novel min‐cut loss, recovers these subtle patterns.
Roxana Zahedi +7 more
wiley +1 more source
Redefining chronic toxoplasmosis--a T cell exhaustion perspective. [PDF]
PLoS Pathogens, 2012 Rajarshi Bhadra, Imtiaz A Khan
doaj +1 more source
T-cell exhaustion in glioblastoma
Oncotarget, 2018 Woroniecka, Karolina, Fecci, Peter E.
openaire +2 more sources
Inverse Design of Pre‐Strain via a Predictive Electromechanical Model for Enhanced Strain Sensing
Advanced Science, EarlyView.An analytical electromechanical model rooted in microcrack evolution mechanics is globally calibrated from only eight pre‐strain datasets, enabling prediction of the complete sensing response at untested pre‐strain values within the calibrated design space (R2 > 0.99).
Jia‐Chen Shang +10 more
wiley +1 more source
Transcriptional suppression of CD8+ T cell exhaustion for improving T cell immunotherapy
Cancer Communications, 2021 Xue Yang, Bingjing Wang, Xuetao Cao
doaj +1 more source
Enforced BATF expression via clinically approved LNPs enhances adoptive T-cell therapies
Blood ScienceChimeric antigen receptor (CAR) T-cell therapy is highly effective in hematologic malignancies, yet its durability is limited by insufficient expansion, persistence, and T-cell exhaustion.
Hanchi Ge +8 more
doaj +1 more source