Results 191 to 200 of about 96,959 (285)

The role of IgM anti‐acetylated protein antibodies and B cells in the origin of anti‐modified protein autoimmunity in rheumatoid arthritis

Arthritis &Rheumatology, Accepted Article.
Objective Rheumatoid arthritis (RA) is characterized by anti‐modified protein antibodies (AMPAs), including anti‐citrullinated (ACPA), anti‐carbamylated (anti‐CarP), and anti‐acetylated (AAPA) protein antibodies. In contrast to other AMPAs, AAPA IgM is found in healthy individuals, raising questions about its role in early immune responses.
Aegli Athanasiadou, Sanne Kroos, Renee van de Wetering, Rian Schopmeijer, Carin van der Keur HLO, Michael Eikmans, Caroline Meijer, Solbritt Rantapää‐Dahlqvist, René E.M. Toes, Linda M. Slot, Diane van der Woude   +10 more
wiley   +1 more source

Large-Scale T-cell Receptor Repertoire Profiling Unveils Tumor-Specific Signals for Diagnosing Indeterminate Pulmonary Nodules. [PDF]

Cancer Res
Luo H, Guo W, Luan X, Yue T, Yu S, Yin X, Zu R, Rao L, Hu B, Liu X, Xiang R, Zhou P, Liu J, Zhang P, Chen Y, Zhang X, Zhou S, Wang J, Li ZC, Qin W, Yang X, Gu J, Guo AY, Xu M, Yi Q, Huang J, Liu J, Wang D, Chen S.   +28 more
europepmc   +1 more source

Immunoinformatics‐Based Design of a Multi‐Epitope Vaccine Targeting a Conserved Copper–Associated Protein in Neisseria gonorrhoeae

Biotechnology and Applied Biochemistry, EarlyView.
ABSTRACT Neisseria gonorrhoeae poses an urgent public health challenge due to rapidly increasing antimicrobial resistance and the absence of an effective vaccine. Targeting conserved bacterial pathways involved in essential physiological processes may provide new opportunities for vaccine antigen discovery.
Sinethemba H. Yakobi, Uchechukwu U. Nwodo   +1 more
wiley   +1 more source

Resistance potential of the HLA-A2-restricted immunodominant SARS-CoV-2-specific CD8⁺ T cell receptor repertoire to antigenic drift. [PDF]

Nat Commun
Malone MJ, Huang C, Zhang Y, Qi Y, Williams L, Su LF, Lou J, Jiang N.   +7 more
europepmc   +1 more source

Comment on 'rigorous benchmarking of T cell receptor repertoire profiling methods for cancer RNA sequencing'. [PDF]

Brief Bioinform, 2023
Davydov AN, Bolotin DA, Poslavsky SV, Chudakov DM.   +3 more
europepmc   +1 more source

Nanomaterial‐based immune therapeutic strategies in neurodegenerative diseases

BMEMat, EarlyView.
This review highlights the immunomodulatory potential of nanomaterials (NMs) in treating neurodegenerative diseases (NDs). It focuses on their roles in regulating innate and adaptive immune responses to maintain immune homeostasis. By providing insights into these mechanisms, the review lays the groundwork for innovative NMs therapeutic strategies to ...
Xinru Zhou, Jia Liu, Shulin Lai, Suhan Yin, Bingmin Luo, Longquan Shao, Yiyuan Kang   +6 more
wiley   +1 more source

Predictive potential of patient-specific immunological characteristics in solid cancers: circulating monocytes, myeloid-derived suppressor cells, T cells, and the T-cell receptor repertoire. [PDF]

ESMO Open
Zierfuss C, Niederdorfer B, Fendl B, Syböck K, Schedl J, Kohl L, Heller G, Tomasich E, Berger JM, Sunder-Plassmann V, Kleinberger M, Gottmann L, Korpan M, Starzer AM, Solano Henao I, Fürst J, Wolfsberg J, Grohmannova M, Dobrovits N, Ay C, Vladic N, Furtner J, Preusser M, Berghoff AS.   +23 more
europepmc   +1 more source

Mimic, target, and adapt: Cell membrane‐coated nanoplatforms for precision and immune‐guided cancer treatment

BMEMat, EarlyView.
This Perspective explores the emerging landscape of cell membrane‐coated nanoparticles (CM‐NPs) as intelligent, immune‐compatible platforms for cancer therapy. Highlighting design strategies, translational challenges, and competitive positioning, it outlines how integrating biomimetic targeting with advanced analytical and manufacturing tools could ...
A. K. M. M. Alam, Xiaojun Cai, Malik Ihsan Ullah Khan, Robert Musiol, Quazi T. H. Shubhra   +4 more
wiley   +1 more source

Investigating Early Kinetics in Plasma ctDNA and Peripheral T-cell Receptor Repertoire to Predict Treatment Outcomes to PD-1 Inhibitors in Head and Neck Squamous Cell Carcinoma. [PDF]

Clin Cancer Res
Sanz-Garcia E, Soleimani S, Bruce JP, Pedersen S, Tang M, Avery L, Eagles J, Spreafico A, Hansen AR, Eng L, Laliotis G, Krainock M, Liu M, Basra P, Yu C, Felicen S, Ohashi PS, Bratman SV, Pugh TJ, Siu LL.   +19 more
europepmc   +1 more source

T-Cell Receptor Repertoire as a Predictor of Immune-Related Adverse Events in Renal Cell Carcinoma. [PDF]

Curr Issues Mol Biol, 2023
Kobayashi T, Nagata M, Ikehata Y, Nagashima Y, Nagaya N, Lu Y, Horie S.   +6 more
europepmc   +1 more source