Results 201 to 210 of about 96,959 (285)

Harnessing ferroptosis from multilayer defense networks to nanoplatforms for specific cancer therapy

BMEMat, EarlyView.
Nanomaterials target metabolically‐regulated ferroptosis for cancer therapy. Iron‐based or alternative nanoplatforms integrate ferroptosis with chemotherapy, immunotherapy, or radiotherapy. They enable stimulus‐responsive therapies (photothermal, photodynamic, sonodynamic) activated by near‐infrared, light, or ultrasound, achieving potent synergistic ...
Xinyue Xu, Xuejian Wang, Wenyan Jiang, Wan Hairul Anuar Kamaruddin, Chunyan Fang, Pengfei Zhang   +5 more
wiley   +1 more source

Defining the genetic determinants of CD8⁺ T cell receptor repertoire in the context of immune checkpoint blockade. [PDF]

Sci Adv
Ng ES, Milotay G, Tong O, A Taylor C, Sun S, Niu G, Watson R, Sun B, MacKay S, Gilchrist JJ, Little M, Fairfax BP, Luo Y.   +12 more
europepmc   +1 more source

Individualised niches: an integrative conceptual framework across behaviour, ecology, and evolution

Biological Reviews, EarlyView.
ABSTRACT Individuals differ. While seemingly trivial, this insight has nevertheless led to paradigm shifts, as three key fields of organismal biology have seen marked changes in key concepts over the past few decades. In animal behaviour, it has become increasingly recognised that behavioural differences among individuals can be stable over time and ...
Oliver Krüger, Jaime Anaya‐Rojas, Mitja Back, Barbara Caspers, Nayden Chakarov, Melanie Dammhahn, Alkistis Elliott‐Graves, Claudia Fricke, Jürgen Gadau, Joseph I. Hoffman, Marie I. Kaiser, Sylvia Kaiser, Peter Korsten, Ulrich Krohs, Joachim Kurtz, Roland Langrock, Caroline Müller, Robert Peuß, Klaus Reinhold, Helene Richter, Norbert Sachser, Holger Schielzeth, Tim Schmoll, Ralf Stanewsky, Tamas Szekely, Franz J. Weissing, Meike Wittmann, Shuqing Xu   +27 more
wiley   +1 more source

Mice with a diverse human T cell receptor repertoire selected on multiple HLA class I molecules. [PDF]

Nat Commun
Dhamodaran A, Chen X, Fellmer N, Agrawal D, Danner E, Kühn R, Blankenstein T.   +6 more
europepmc   +1 more source

A neuro‐behavioural model of neophobia

Biological Reviews, EarlyView.
ABSTRACT Fear can be defined as the internal neurological state that releases a repertoire of behaviours an animal performs to reduce the effect of an aversive factor. Neophobia, the fear of novelty, is a fundamental behavioural trait observed across a wide range of species from arthropods to humans.
Arik Dorfman, Aziz Subach, Inon Scharf
wiley   +1 more source

Comprehensive αβ T-Cell Receptor Repertoire Analysis Reveals a Unique CD8+ TCR Landscape in DOCK8-Deficient Patients. [PDF]

Allergy
Bozkurt C, Cildir G, Aba U, Erdogan RK, Warnock NI, Kok CH, Sefer AP, Haskologlu S, Tekeoglu SD, Kılınç GM, Ipsir C, Arikoglu T, Ozhan AK, Esenboga S, Özen A, Karakoç-Aydiner E, Eltan SB, Aydogmus Ç, Islamoglu C, Baskın K, Karaatmaca B, Metin A, Çagdaş D, Dogu F, Ikinciogullari A, Baris S, Erman B.   +26 more
europepmc   +1 more source

On the importance of including both sexes in animal studies – insights from home‐cage monitoring

Biological Reviews, EarlyView.
ABSTRACT A review of behavioural studies using home‐cage monitoring (HCM) systems revealed that over 61% of studies used only male subjects, with only 24% including both sexes, despite evidence of substantial behavioural differences between male and female animals. This bias could influence the outcomes of biomedical research.
Maša Čater, Adam Dušek, Aleksandra Bartelik, Silvia Mandillo, Elisabetta Golini, Mara Rigamonti, Rasneer Sonia Bains, Hamish Forrest, Marion Rivalan, Melissa Long, Anna Kiryk, Lars Lewejohann, Nuno Henrique Franco   +12 more
wiley   +1 more source

Prognostic Implications of T Cell Receptor Repertoire Diversity in Cervical Lymph Nodes of Oral Squamous Cell Carcinoma Patients. [PDF]

Int J Mol Sci
Kumagai K, Hamada Y, Horie A, Shimizu Y, Ohashi Y, Aoki R, Suzuki T, Kawaguchi K, Kuroda A, Tsujikawa T, Hoshi K, Kakimi K.   +11 more
europepmc   +1 more source

Utterance evolution: the road to generative, combinatorial communicators

Biological Reviews, EarlyView.
ABSTRACT Language has long been considered uniquely complex in the animal kingdom; however, animal research over the last decade has begun to challenge some long‐standing premises about exactly which language capacities are uniquely human. The task of resolving why and how complex communication systems evolve, particularly human language, has ...
Catherine Crockford, Roman Martin Wittig, Cedric Girard‐Buttoz   +2 more
wiley   +1 more source

SARS-CoV-2 vaccines induce a diverse spike-specific CD4+ T cell receptor repertoire in people living with HIV with low CD4 nadirs. [PDF]

Front Immunol
Mercado A, Sop J, Amanat S, Zhang L, Chida NM, Basseth CR, Gebo KA, Antar AAR, Smith KN, Zeng Z, Blankson JN.   +10 more
europepmc   +1 more source