Results 61 to 70 of about 96,959 (285)

Reduced diversity of intestinal T-cell receptor repertoire in patients with Crohn’s disease

Frontiers in Cellular and Infection Microbiology, 2022
BackgroundThe intestinal microenvironment directly determines the human T-cell receptor (TCR) repertoire. Despite its extreme diversity, TCR repertoire analysis may provide a better understanding of the immune system in patients with inflammatory bowel ...
Sung Noh Hong, Sung Noh Hong, Joo-Young Park, So-Yun Yang, Chansu Lee, Chansu Lee, Young-Ho Kim, Je-Gun Joung   +7 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Development of human monoclonal antibodies against TARM1 by yeast display

FEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe, Mayumi Saeki, Masaaki Hashiguchi, Sayaka Ono, Kazuhisa Aoki, Hidetaka Tanno   +5 more
wiley   +1 more source

A viral CTL escape mutation leading to immunoglobulin-like transcript 4-mediated functional inhibition of myelomonocytic cells [PDF]

, 2007
Viral mutational escape can reduce or abrogate recognition by the T cell receptor (TCR) of virus-specific CD8+ T cells. However, very little is known about the impact of cytotoxic T lymphocyte (CTL) epitope mutations on interactions between peptide–major
Feeney, M, Allgaier, Rachel, Marcus Altfeld, Feeney, Margaret, Williams, KL, Sivamurthy, R, Pereyra, F, Allgaier, R, Rohini Sivamurthy, Stanley K. Mui, Rosenberg, Eric S, Allen, Todd M, Altfeld, M, Eric S. Rosenberg, Pereyra, Florencia, Rachel Allgaier, Trocha, Alicja, Todd M. Allen, Moza, Beenu, Allen, TM, Eric J. Sundberg, Mui, SK, Bruce D. Walker, Sundberg, EJ, Katie L. Williams, Gandhi, RT, Yu, Xu G, Rachel Allen, Daniel G. Kavanagh, Beenu Moza, Sundberg, Eric J, Alicja Trocha, Gandhi, Rajesh T, Moza, B, Margaret Feeney, Xu G. Yu, Rosenberg, ES, Mui, Stanley K, Mathias Lichterfeld, Florencia Pereyra, Walker, BD, Rajesh T. Gandhi, Sivamurthy, Rohini, Kavanagh, DG, Trocha, A, Lichterfeld, Mathias, Allen, R, Lichterfeld, M, Williams, Katie L, Allen, Rachel, ToshiYuki Miura, Miura, ToshiYuki, Walker, Bruce D, Miura, T, Yu, XG, Kavanagh, Daniel G, Altfeld, Marcus   +56 more
core   +1 more source

Comparative analysis of murine T‐cell receptor repertoires [PDF]

Immunology, 2017
SummaryFor understanding the rules and laws of adaptive immunity, high‐throughput profiling of T‐cell receptor (TCR) repertoires becomes a powerful tool. The structure of TCR repertoires is instructive even before the antigen specificity of each particular receptor becomes available.
Mark Izraelson, Tatiana O. Nakonechnaya, Bruno Moltedo, Evgeniy S. Egorov, Sofya A. Kasatskaya, Ekaterina V. Putintseva, Ilgar Z. Mamedov, Dmitriy B. Staroverov, Irina I. Shemiakina, Maria Y. Zakharova, Alexey N. Davydov, Dmitriy A. Bolotin, Mikhail Shugay, Dmitriy M. Chudakov, Alexander Y. Rudensky, Olga V. Britanova   +15 more
openaire   +2 more sources

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

TCR3d: The T cell receptor structural repertoire database [PDF]

Bioinformatics, 2019
Abstract Summary T cell receptors (TCRs) are critical molecules of the adaptive immune system, capable of recognizing diverse antigens, including peptides, lipids and small molecules, and represent a rapidly growing class of therapeutics.
Ragul Gowthaman, Brian G. Pierce
openaire   +2 more sources

Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina, Anna Marcé‐Grau, Barbara Masotto, Marta Codina, Lamia BenJemaa, Yasmina Elaribi, Mónica Martinez‐Gallo, Roger Colobran, Angel Sanchez‐Montañez, Irene Valenzuela, Yoshiko Murakami, Alfons Macaya   +11 more
wiley   +1 more source

T Cell Repertoire Dynamics during Pregnancy in Multiple Sclerosis

Cell Reports, 2019
Summary: Identifying T cell clones associated with human autoimmunity has remained challenging. Intriguingly, many autoimmune diseases, including multiple sclerosis (MS), show strongly diminished activity during pregnancy, providing a unique research ...
Caren Ramien, Erik C. Yusko, Jan Broder Engler, Stefanie Gamradt, Kostas Patas, Nils Schweingruber, Anne Willing, Sina Cathérine Rosenkranz, Anke Diemert, Anja Harrison, Marissa Vignali, Catherine Sanders, Harlan S. Robins, Eva Tolosa, Christoph Heesen, Petra C. Arck, Alexander Scheffold, Kenneth Chan, Ryan O. Emerson, Manuel A. Friese, Stefan M. Gold   +20 more
doaj   +1 more source

Analysis of T-Cell Receptor Repertoire in Transplantation: Fingerprint of T Cell-mediated Alloresponse

Frontiers in Immunology, 2022
T cells play a key role in determining allograft function by mediating allogeneic immune responses to cause rejection, and recent work pointed their role in mediating tolerance in transplantation. The unique T-cell receptor (TCR) expressed on the surface
Guangyao Tian, Mingqian Li, Guoyue Lv
doaj   +1 more source