Advanced Science, EarlyView.Gasdermin D (GSDMD) does not only reduce pancreatic enzyme synthesis but also induces pancreatic acinar cells to express mucin 1 (MUC1), which forms a barrier to prevent digestive enzyme‐mediated digestion. However, GSDMD can promote the secretion of inflammatory cytokines by macrophages and aggravate pancreatic histological injury by expanding ...
Chaoxu Liu +10 more
wiley +1 more source
Fragment Autoantigens Stimulated T‐Cell‐Immunotherapy (FAST) as a Fast Autologous Cancer Vaccine
Advanced Science, EarlyView.A personalized whole tumor cell vaccine (FAST) is developed to address immunosuppressive tumor microenvironments and genomic instability‐driven heterogeneity. Irradiation and cryoablation‐treated tumor cells generate fragmented antigens (FAs) that activate broad‐spectrum antigen presentation via upregulated immunogenic cell death, MHC‐I, and damage ...
Yuan Li +14 more
wiley +1 more source
A therapy that modulates T lymphocyte subsets in patients infected with Epstein-Barr virus: Ganciclovir combined with interferon atomization inhalation. [PDF]
Medicine (Baltimore), 2023 Ren Q, Feng Y.
europepmc +1 more source
Characterization of T lymphocyte subsets with monoclonal antibodies: discovery of a distinct marker, Ly-m22, of T suppressor cells. [PDF]
, 1983 Maria Chan +6 more
openalex +1 more source
A model for the differentiation of human natural killer cells. Studies on the in vitro activation of Leu-11+ granular lymphocytes with a natural killer-sensitive tumor cell, K562. [PDF]
, 1985 A subpopulation of low density granular lymphocytes that express the natural killer (NK) cell-associated Leu-11 antigen (IgG Fc receptor) were stimulated directly by coculture with an NK-sensitive tumor cell, K562.
Lanier, LL, Phillips, JH
core
Advanced Science, EarlyView.This study integrates scRNA‐seq, multiplex immunofluorescence, and clinical data to identify HLA‐DR⁺tumor cells uniquely enriched in Hepatocellular carcinoma (HCC) with hepatitis B virus (HBV). These cells express MHC II, associate with PD‐L1, recruit and exhaust CD8⁺T cells, predict poor survival, and serve as potential biomarkers for immunotherapy ...
Jun‐Qing Chang +17 more
wiley +1 more source
Expression of T-cell-activating protein in peripheral lymphocyte subsets.
, 1986 E T Yeh +3 more
openalex +1 more source
In vitro locomotion of allosensitized T lymphocyte clones in response to metabolites of arachidonic acid is subset specific. [PDF]
, 1986 Mark L. Jordan +3 more
openalex +1 more source
Advanced Science, EarlyView.Multiple therapeutic modalities combined in a synergistic way that can modulate different immune axes are demonstrated potentially effective in boosting immunotherapy. A nucleic acid‐locked smart carrier (NASC) performed as an “all‐in‐one” nanoplatform is constructed for efficient eliciting chemo‐ and photothermal‐amplified immunogenic cell death to ...
Jiayang Zhang +6 more
wiley +1 more source
Frequent somatic mosaicism in T lymphocyte subsets in individuals with and without multiple sclerosis. [PDF]
Front Immunol, 2022 Van Horebeek L +3 more
europepmc +1 more source