Results 201 to 210 of about 58,285 (234)

T follicular regulatory cells in mice and men [PDF]

Immunology, 2017
SummaryIt has long been known that CD4 T cells are necessary to provide help to B cells, triggering a germinal centre (GC) reaction where affinity maturation and isotype switching occur. However, the nature of the dedicated CD4 helper T cells, known as T follicular helper (Tfh), was only recently described.
Valter R Fonseca, Luis Graça, Ana Raquel Maceiras   +2 more
exaly   +3 more sources

Follicular regulatory T cells impair follicular T helper cells in HIV and SIV infection [PDF]

Nature Communications, 2015
AbstractHuman and simian immunodeficiency viruses (HIV and SIV) exploit follicular lymphoid regions by establishing high levels of viral replication and dysregulating humoral immunity. Follicular regulatory T cells (TFR) are a recently characterized subset of lymphocytes that influence the germinal centre response through interactions with follicular ...
Martin Mccarter, Eva Gizella Rakasz, David N Levy   +2 more
exaly   +3 more sources

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The expanding family of T follicular regulatory cells

Science Immunology, 2023
The coevolution of multiple specialized T follicular regulatory cell subsets has led to fine-tuning of human germinal center responses in providing optimal antibody production and preventing events leading to autoimmunity (see the related Research Article by Le Coz et al .).
Luis Graca, Johanne Jacobsen, Saumya Kumar   +2 more
openaire   +2 more sources

T follicular helper cells and T follicular regulatory cells in rheumatic diseases

Nature Reviews Rheumatology, 2019
As a hallmark of autoimmune rheumatic diseases, autoantibodies have been used in diagnosis for decades. However, the immunological mechanism underlying their generation has only become clear following the identification of T follicular helper (TFH) cells and T follicular regulatory (TFR) cells. TFH cells are instrumental in supporting antibody affinity
Valter R Fonseca, Luis Graça, Jun Deng   +2 more
exaly   +6 more sources

The Role of Follicular Regulatory T Cells/Follicular Helper T Cells in Primary Immune Thrombocytopenia

Acta Haematologica, 2023
Introduction: Immune thrombocytopenia (ITP) is an autoimmune disease characterized by thrombocytopenia. Herein, we sought to identify potential immune-related therapeutic targets in ITP. Methods: The differentially expressed genes (DEGs) between ITP patients and controls in GSE43177 and PRJNA299534 were analyzed. The intersections of the two DEG groups
Mingling, Sun, Xiujuan, Wang, Lei, Wang, Xinyou, Wang, Wenxia, Fan, Ying, Liu, Qinzhi, Li, Ning, Zhang, Xinhong, Guo   +8 more
openaire   +2 more sources

Follicular regulatory T cells produce neuritin to regulate B cells

Cell, 2021
Regulatory T cells prevent the emergence of autoantibodies and excessive IgE, but the precise mechanisms are unclear. Here, we show that BCL6-expressing Tregs, known as follicular regulatory T (Tfr) cells, produce abundant neuritin protein that targets B cells.
Michelle Linterman, Alexander Dent, Paula González-Figueroa   +2 more
exaly   +5 more sources

T follicular helper and T follicular regulatory cells in colorectal cancer: A complex interplay

Journal of Immunological Methods, 2020
Colorectal cancer is considered to be one of the major causes of morbidity and mortality all over the world. T Follicular helper (TFH) and T follicular regulatory (TFR) cells are specialized providers of T-cells to help B-cells and shaping germinal centers (GC) response.
Azza Elkady, Helal F Hetta, Israa M S Al-Kadmy   +2 more
exaly   +3 more sources

SOSTDC1-producing follicular helper T cells promote regulatory follicular T cell differentiation

Science, 2020
SOSTDC1 for germinal center regulation T follicular helper (T FH ) cells are CD4 + T cells that facilitate B cell antibody production and B cell memory responses in the germinal centers (GCs) of lymphoid organs. These activities are in turn restrained by T follicular regulatory (T
Xin Wu, Yun Wang, Rui Huang, Qujing Gai, Haofei Liu, Meimei Shi, Xiang Zhang, Yonglin Zuo, Longjuan Chen, Qiwen Zhao, Yu Shi, Fengchao Wang, Xiaowei Yan, Huiping Lu, Senlin Xu, Xiaohong Yao, Lin Chen, Xia Zhang, Qiang Tian, Ziyan Yang, Bo Zhong, Chen Dong, Yan Wang, Xiu-Wu Bian, Xindong Liu   +24 more
openaire   +2 more sources

T follicular regulatory cells

Immunological Reviews, 2016
SummaryPathogen exposure elicits production of high‐affinity antibodies stimulated by T follicular helper (Tfh) cells in the germinal center reaction. Tfh cells provide both costimulation and stimulatory cytokines to B cells to facilitate affinity maturation, class switch recombination, and plasma cell differentiation within the germinal center.
Peter T, Sage, Arlene H, Sharpe
openaire   +2 more sources