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SummaryT follicular helper (Tfh) cells are critical mediators of germinal center (GC) formation and essential for potent humoral immunity. In contrast, T follicular regulatory (Tfr) cells, which share characteristics of both stimulatory Tfh cells and suppressive regulatory T (Treg) cells, restrain excessive GC responses.
Julia Maul +2 more
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Regulation of the IgE response by T follicular regulatory cells
Journal of Allergy and Clinical Immunology, 2022Qiang, Chen, Alexander L, Dent
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T follicular helper cells and T follicular regulatory cells in Systemic Lupus Erythematosus
2018Systemic lupus erythematosus (SLE) is a chronic systemic autoimmune disease characterized by the generation of autoantibodies directed against nuclear, cytoplasmic and membrane-associated self-components. Recent studies found that autoantibody-producing B cells are originated from germinal centres (GC) in lymphoid organs, a site for B cell affinity ...
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Foxp3+ follicular regulatory T cells control the germinal center response
Nature Medicine, 2011Michelle Linterman +2 more
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Follicular regulatory T cells expressing Foxp3 and Bcl-6 suppress germinal center reactions
Nature Medicine, 2011Yeonseok Chung +2 more
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The Kinase mTORC1 Promotes the Generation and Suppressive Function of Follicular Regulatory T Cells
Immunity, 2017Qiang Bai, Xiangyu Chen, Xinyuan Zhou
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A distinct subpopulation of CD25−T-follicular regulatory cells localizes in the germinal centers
Proceedings of the National Academy of Sciences of the United States of America, 2017Shimon Sakaguchi +2 more
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