Identifying Follicular Regulatory T Cells by Confocal Microscopy
2017Follicular regulatory T cells are a subset of Foxp3+ regulatory T cells that migrate into the B cell follicle after infection or immunization and modulate the germinal center response. The anatomical positioning of follicular regulatory T cells within the germinal center is a defining characteristic of this subset of regulatory T cells; because of this,
Ine, Vanderleyden, Michelle A, Linterman
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SummaryT follicular helper (Tfh) cells are critical mediators of germinal center (GC) formation and essential for potent humoral immunity. In contrast, T follicular regulatory (Tfr) cells, which share characteristics of both stimulatory Tfh cells and suppressive regulatory T (Treg) cells, restrain excessive GC responses.
Julia Maul +2 more
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Follicular Regulatory T cell migration and differentiation
2019The Cambridge ...
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T follicular helper cells and T follicular regulatory cells in Systemic Lupus Erythematosus
2018Systemic lupus erythematosus (SLE) is a chronic systemic autoimmune disease characterized by the generation of autoantibodies directed against nuclear, cytoplasmic and membrane-associated self-components. Recent studies found that autoantibody-producing B cells are originated from germinal centres (GC) in lymphoid organs, a site for B cell affinity ...
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New developments in the diagnosis and treatment of thyroid cancer
Ca-A Cancer Journal for Clinicians, 2013David F Schneider, Herbert Chen
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Foxp3+ follicular regulatory T cells control the germinal center response
Nature Medicine, 2011Michelle A Linterman +2 more
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Follicular regulatory T cells expressing Foxp3 and Bcl-6 suppress germinal center reactions
Nature Medicine, 2011Yeonseok Chung +2 more
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The Kinase mTORC1 Promotes the Generation and Suppressive Function of Follicular Regulatory T Cells
Immunity, 2017Qiang Bai, Jianjun Hu, Xiangyu Chen
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Mechanisms of t follicular regulatory cell differentiation
Respostas imunológicas humorais protetoras coordenadas pelas células B, quer em resposta a infeções ou à vacinação, requerem a participação de células T. Entre estas, as células T foliculares auxiliares (Tfh) emergiram como elementos-chave, fornecendo ajuda às células B e facilitando a produção de anticorpos de alta afinidade.openaire +1 more source
The receptor PD-1 controls follicular regulatory T cells in the lymph nodes and blood
Nature Immunology, 2012Peter T Sage +2 more
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