Results 211 to 220 of about 58,285 (234)

Current Advances in Follicular Regulatory T-Cell Biology

Critical Reviews in Immunology, 2022
Follicular regulatory T (T_FR) cells are a population of CD4⁺ T-cells that concomitantly express markers for regulatory T-cells and follicular helper T (T_FH) cells, and have been predominantly implicated in the regulation of humoral immunity via their suppressive functions.
Sadashib, Ghosh, Jianmei W, Leavenworth
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Follicular helper T cells and follicular regulatory T cells in the immunopathology of primary Sjögren’s syndrome

Journal of Leukocyte Biology, 2020
Abstract Primary Sjögren’s syndrome (pSS) is a chronic autoimmune disease, characterized by lymphocytic infiltration into exocrine glands, which causes dry eyes, dry mouth, and systemic damage. Although the precise etiology of pSS is not clear yet, highly activated B cells, abundant anti-SSA/Ro, and anti-SSB/La autoantibodies are the ...
Weiqian, Chen, Fan, Yang, Guanhua, Xu, Jilin, Ma, Jin, Lin   +4 more
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Detection of T Follicular Helper Cells and T Follicular Regulatory Cells in Experimental Sjögren’s Syndrome

2021
With the compiling studies on the autoimmune pathogenesis in the developing of Sjögren's syndrome, the functional importance of T follicular helper cells (Tfh) and T follicular regulatory cells (Tfr) was investigated, including our recent findings, among which various techniques for detecting Tfh and Tfr cells in Sjögren's syndrome have been reported ...
Sulan, Yu, Meiling, Wu, Yun, Feng, Jiangang, Shen, Liwei, Lu, Xiang, Lin   +5 more
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Effects of allergen immunotherapy on follicular regulatory T cells

Current Opinion in Allergy & Clinical Immunology, 2023
Purpose of review Emerging evidence indicating that the dysfunction of T follicular regulatory (TFR) cells contributes to excessive immunoglobulin E (IgE) production and the development of allergic diseases. Conversely, allergen immunotherapy (AIT) modulates TFR cells abundance and function to promote immune tolerance.
Shi-Ran, Sun, Yin, Yao, Zheng, Liu
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Developmental bifurcation of human T follicular regulatory cells

Science Immunology, 2021
Transcriptomics supports that human T reg cells differentiate into mature lymphoid tissue or circulating T follicular regulatory cells.
Saumya Kumar, Válter R. Fonseca, Filipa Ribeiro, Afonso P. Basto, Ana Água-Doce, Marta Monteiro, Dikélélé Elessa, Ricardo J. Miragaia, Tomás Gomes, Eliane Piaggio, Elodie Segura, Margarida Gama-Carvalho, Sarah A. Teichmann, Luis Graca   +13 more
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Advances in T follicular helper and T follicular regulatory cells in transplantation immunity

Transplantation Reviews, 2018
B cells play a crucial role in alloreactivity of organ transplant rejection and graft versus host diseases (GVHD). Over the past decade, it has been well recognized that B-cell infiltration in allografts and de novo donor-specific antibodies (DSA) were strongly associated with severe graft rejection and loss, as well as glucocorticoid resistance ...
Maogen Chen, Xiaohong Lin, null Cheukfai Li, Nancy Olsen, Xiaoshun He, Song Guo Zheng   +5 more
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Nonbinary Roles for T Follicular Helper Cells and T Follicular Regulatory Cells in the Germinal Center Response

The Journal of Immunology, 2023
Abstract Development of high-affinity Abs in the germinal center (GC) is dependent on a specialized subset of T cells called “T follicular helper” (TFH) cells that help select Ag-specific B cells. A second T cell subset, T follicular regulatory (TFR) cells, can act as repressors of the GC and Ab response but can also provide a helper ...
Qiang Chen, Alexander L Dent
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Follicular Helper T Cells and Follicular Regulatory T Cells Involved in Immune Disorders of Idiopathic Membranous Nephropathy

Indian Journal of Pediatrics, 2023
To investigate the role of follicular helper T (Tfh) cells and follicular regulatory T (Tfr) cells in immune disorders of idiopathic membranous nephropathy (IMN).Peripheral blood samples of 41 IMN patients and 30 healthy controls were collected.
Lin, Xu, Dilreba, Tayier, Shufen, Yang, Xueqin, Zhang, Chen, Lu   +4 more
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Identifying Follicular Regulatory T Cells by Confocal Microscopy

2017
Follicular regulatory T cells are a subset of Foxp3+ regulatory T cells that migrate into the B cell follicle after infection or immunization and modulate the germinal center response. The anatomical positioning of follicular regulatory T cells within the germinal center is a defining characteristic of this subset of regulatory T cells; because of this,
Ine, Vanderleyden, Michelle A, Linterman
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AB0043 THE IMBALANCE OF T FOLLICULAR REGULATORY CELL AND T FOLLICULAR HELPER CELL IN RHEUMATOID ARTHRITIS

Annals of the Rheumatic Diseases, 2020
Background: Rheumatoid arthritis (RA) is a chronic inflammatory disease which can lead to severe joint damage and disability.The relationship between antibodies and rheumatoid arthritis has long been well established. Recently, many studies have found that T follicular regulatory cells(Tfr) and T follicular helper cells (Tfh) are closely related to ...
R. Su, Y.Y. Wang, F.Y. Hu, X. Zheng, Y. Liu, X. Li, C. Wang   +6 more
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