Results 211 to 220 of about 56,618 (238)

SOSTDC1-producing follicular helper T cells promote regulatory follicular T cell differentiation

Science, 2020
SOSTDC1 for germinal center regulation T follicular helper (T FH ) cells are CD4 + T cells that facilitate B cell antibody production and B cell memory responses in the germinal centers (GCs) of lymphoid organs. These activities are in turn restrained by T follicular regulatory (T
Xin Wu, Yun Wang, Rui Huang, Qujing Gai, Haofei Liu, Meimei Shi, Xiang Zhang, Yonglin Zuo, Longjuan Chen, Qiwen Zhao, Yu Shi, Fengchao Wang, Xiaowei Yan, Huiping Lu, Senlin Xu, Xiaohong Yao, Lin Chen, Xia Zhang, Qiang Tian, Ziyan Yang, Bo Zhong, Chen Dong, Yan Wang, Xiu-Wu Bian, Xindong Liu   +24 more
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T follicular regulatory cells

Immunological Reviews, 2016
SummaryPathogen exposure elicits production of high‐affinity antibodies stimulated by T follicular helper (Tfh) cells in the germinal center reaction. Tfh cells provide both costimulation and stimulatory cytokines to B cells to facilitate affinity maturation, class switch recombination, and plasma cell differentiation within the germinal center.
Peter T, Sage, Arlene H, Sharpe
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The Role of Follicular Regulatory T Cells/Follicular Helper T Cells in Primary Immune Thrombocytopenia

Acta Haematologica, 2023
Introduction: Immune thrombocytopenia (ITP) is an autoimmune disease characterized by thrombocytopenia. Herein, we sought to identify potential immune-related therapeutic targets in ITP. Methods: The differentially expressed genes (DEGs) between ITP patients and controls in GSE43177 and PRJNA299534 were analyzed. The intersections of the two DEG groups
Mingling, Sun, Xiujuan, Wang, Lei, Wang, Xinyou, Wang, Wenxia, Fan, Ying, Liu, Qinzhi, Li, Ning, Zhang, Xinhong, Guo   +8 more
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Detection of T Follicular Helper Cells and T Follicular Regulatory Cells in Experimental Sjögren’s Syndrome

2021
With the compiling studies on the autoimmune pathogenesis in the developing of Sjögren's syndrome, the functional importance of T follicular helper cells (Tfh) and T follicular regulatory cells (Tfr) was investigated, including our recent findings, among which various techniques for detecting Tfh and Tfr cells in Sjögren's syndrome have been reported ...
Sulan, Yu, Meiling, Wu, Yun, Feng, Jiangang, Shen, Liwei, Lu, Xiang, Lin   +5 more
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Advances in T follicular helper and T follicular regulatory cells in transplantation immunity

Transplantation Reviews, 2018
B cells play a crucial role in alloreactivity of organ transplant rejection and graft versus host diseases (GVHD). Over the past decade, it has been well recognized that B-cell infiltration in allografts and de novo donor-specific antibodies (DSA) were strongly associated with severe graft rejection and loss, as well as glucocorticoid resistance ...
Maogen Chen, Xiaohong Lin, null Cheukfai Li, Nancy Olsen, Xiaoshun He, Song Guo Zheng   +5 more
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T follicular helper and T follicular regulatory cells in colorectal cancer: A complex interplay

Journal of Immunological Methods, 2020
Colorectal cancer is considered to be one of the major causes of morbidity and mortality all over the world. T Follicular helper (TFH) and T follicular regulatory (TFR) cells are specialized providers of T-cells to help B-cells and shaping germinal centers (GC) response.
Helal F, Hetta, Azza, Elkady, Ramadan, Yahia, Ahmed Kh, Meshall, Mahmoud M, Saad, Mohamed A, Mekky, Israa M S, Al-Kadmy   +6 more
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Effects of allergen immunotherapy on follicular regulatory T cells

Current Opinion in Allergy & Clinical Immunology, 2023
Purpose of review Emerging evidence indicating that the dysfunction of T follicular regulatory (TFR) cells contributes to excessive immunoglobulin E (IgE) production and the development of allergic diseases. Conversely, allergen immunotherapy (AIT) modulates TFR cells abundance and function to promote immune tolerance.
Shi-Ran, Sun, Yin, Yao, Zheng, Liu
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Follicular helper T cells and follicular regulatory T cells in the immunopathology of primary Sjögren’s syndrome

Journal of Leukocyte Biology, 2020
Abstract Primary Sjögren’s syndrome (pSS) is a chronic autoimmune disease, characterized by lymphocytic infiltration into exocrine glands, which causes dry eyes, dry mouth, and systemic damage. Although the precise etiology of pSS is not clear yet, highly activated B cells, abundant anti-SSA/Ro, and anti-SSB/La autoantibodies are the ...
Weiqian, Chen, Fan, Yang, Guanhua, Xu, Jilin, Ma, Jin, Lin   +4 more
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Follicular Helper T Cells and Follicular Regulatory T Cells Involved in Immune Disorders of Idiopathic Membranous Nephropathy

Indian Journal of Pediatrics, 2023
To investigate the role of follicular helper T (Tfh) cells and follicular regulatory T (Tfr) cells in immune disorders of idiopathic membranous nephropathy (IMN).Peripheral blood samples of 41 IMN patients and 30 healthy controls were collected.
Lin, Xu, Dilreba, Tayier, Shufen, Yang, Xueqin, Zhang, Chen, Lu   +4 more
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Nonbinary Roles for T Follicular Helper Cells and T Follicular Regulatory Cells in the Germinal Center Response

The Journal of Immunology, 2023
Abstract Development of high-affinity Abs in the germinal center (GC) is dependent on a specialized subset of T cells called “T follicular helper” (TFH) cells that help select Ag-specific B cells. A second T cell subset, T follicular regulatory (TFR) cells, can act as repressors of the GC and Ab response but can also provide a helper ...
Qiang Chen, Alexander L Dent
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