Results 11 to 20 of about 153 (129)

Tachykinins modulate nociceptive responsiveness and sensitization: In vivo electrical characterization of primary sensory neurons in tachykinin knockout (Tac1 KO) mice

open access: yesMolecular Pain, 2019
Since the failure of specific substance P antagonists to induce analgesia, the role of tachykinins in the development of neuropathic pain states has been discounted.
Silvia Gutierrez   +4 more
doaj   +1 more source

Differences of Inflammatory Mechanisms in Asthma and COPD

open access: yesAllergology International, 2009
Bronchial asthma and chronic obstructive pulmonary disease (COPD) are increasing common diseases. The major pathogenesis of both illnesses is chronic inflammation. However, the inflammatory pattern is distinct in each disease.
Masakazu Ichinose
doaj   +1 more source

Neurokinin-2 receptor negatively modulates substance P responses by forming complex with Neurokinin-1 receptor

open access: yesCell & Bioscience, 2023
Background Tachykinins and their cognate receptors, neurokinin receptors (NKs) including NK1, NK2, and NK3 play vital roles in regulating various physiological processes including neurotransmission, nociception, inflammation, smooth muscle contractility,
Lan Phuong Nguyen   +11 more
doaj   +1 more source

Blockade of NK-1 receptors in the lateral commissural nucleus tractus solitarii of awake rats had no effect on the cardiovascular responses to chemoreflex activation

open access: yesBrazilian Journal of Medical and Biological Research, 2000
The neurotransmission of the chemoreflex in the nucleus tractus solitarii (NTS), particularly of the sympatho-excitatory component, is not completely understood.
C. Zhang, L.G.H. Bonagamba, B.H. Machado
doaj   +1 more source

Peptidomics of the agriculturally damaging larval stage of the cabbage root fly Delia radicum (Diptera: Anthomyiidae). [PDF]

open access: yesPLoS ONE, 2012
The larvae of the cabbage root fly induce serious damage to cultivated crops of the family Brassicaceae. We here report the biochemical characterisation of neuropeptides from the central nervous system and neurohemal organs, as well as regulatory ...
Judith Zoephel   +4 more
doaj   +1 more source

The role of Substance P in neurodegenerative diseases

open access: yesActa Medica Iranica, 2020
Tachykinins (TKs) are a family of neuropeptides widely distributed in the human body, especially in the nervous system. TKs have exhibited both neuroprotective and neurodegenerative properties in the central nervous system (CNS) and spinal cord.
Seyed Isaac Hashemy   +2 more
doaj   +1 more source

Neurokinin-1 receptor signalling impacts bone marrow repopulation efficiency. [PDF]

open access: yesPLoS ONE, 2013
Tachykinins are a large group of neuropeptides with both central and peripheral activity. Despite the increasing number of studies reporting a growth supportive effect of tachykinin peptides in various in vitro stem cell systems, it remains unclear ...
Alexandra Berger   +8 more
doaj   +1 more source

Autocrine regulation of human sperm motility by tachykinins

open access: yesReproductive Biology and Endocrinology, 2010
Background We examined the presence and function of tachykinins and the tachykinin-degrading enzymes neprilysin (NEP) and neprilysin-2 (NEP2) in human spermatozoa.
Pinto Francisco M   +7 more
doaj   +1 more source

Tachykinin receptors antagonism for asthma: a systematic review

open access: yesBMC Pulmonary Medicine, 2011
Background Tachykinins substance P, neurokinin A and neurokinin B seem to account for asthma pathophysiology by mediating neurogenic inflammation and several aspects of lung mechanics.
Couto Nuno   +3 more
doaj   +1 more source

Neurokinin receptors in the gastrointestinal muscle wall: cell distribution and possible roles

open access: yesBiomolecular Concepts, 2013
The neurokinin receptors are G-protein-linked receptors; three distinct molecules, called neurokinin-1, neurokinin-2, and neurokinin-3 receptors, have been identified.
Vannucchi Maria Giuliana   +1 more
doaj   +1 more source

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