Results 31 to 40 of about 4,888 (209)

Tachykinins: Neuropeptides That Are Ancient, Diverse, Widespread and Functionally Pleiotropic

open access: yesFrontiers in Neuroscience, 2019
Tachykinins (TKs) are ancient neuropeptides present throughout the bilaterians and are, with some exceptions, characterized by a conserved FX1GX2Ramide carboxy terminus among protostomes and FXGLMamide in deuterostomes.
Dick R. Nässel   +3 more
doaj   +1 more source

Neurokinin receptors in the gastrointestinal muscle wall: cell distribution and possible roles

open access: yesBiomolecular Concepts, 2013
The neurokinin receptors are G-protein-linked receptors; three distinct molecules, called neurokinin-1, neurokinin-2, and neurokinin-3 receptors, have been identified.
Vannucchi Maria Giuliana   +1 more
doaj   +1 more source

Plasma substance P and soluble P-selectin as biomarkers of β-thalassemia induced hypercoagulability

open access: yesAlexandria Journal of Medicine, 2014
Background: Hypercoagulability in thalassemia especially in thalassemia major has emerged as a complication of the disease. There is evidence of increased platelet aggregation and increased proportion of platelets expressing P-selectin in thalassemia.
Samia A. Ebeid   +3 more
doaj   +1 more source

Role of tachykinins in asthma

open access: yes, 2000
The sensory neuropeptides substance P (SP) and neurokinin A (NKA) are localized to sensory airway nerves, from which they can be released by a variety of stimuli, including allergen, ozone, or inflammatory mediators.
Joos, Guy   +2 more
core   +1 more source

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

open access: yesFEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen   +8 more
wiley   +1 more source

Actions of Tachykinins Within the Heart and Their Relevance to Cardiovascular Disease

open access: yes, 2000
Substance P and neurokinin A are tachykinins that are co-localized with calcitonin gene-related peptide (CGRP) in a unique subpopulation of cardiac afferent nerve fibers.
John C. Hancock   +7 more
core   +1 more source

One‐Pot Fabrication of Pentapeptide Bio‐Aerogel via Direct Alcogelation

open access: yesSmall, EarlyView.
A minimal tachykinin‐inspired pentapeptide (TC‐1) self‐assembles in water and ethanol to form robust gels that can be dried in one pot to ultra‐porous aerogels using supercritical carbon dioxide. Solvent choice programs nanoscale packing and bulk mechanics producing lightweight monoliths with high porosity for biomaterials applications, verified by ...
Brody McDonald   +6 more
wiley   +1 more source

Tachykinin-related peptides modulate immune-gene expression in the mealworm beetle Tenebrio molitor L.

open access: yesScientific Reports, 2022
Tachykinins (TKs) are a group of conserved neuropeptides. In insects, tachykinin-related peptides (TRPs) are important modulators of several functions such as nociception and lipid metabolism.
Arkadiusz Urbański   +8 more
doaj   +1 more source

Tachykinins and bombesin excite non-pyramidal neurones in rat hippocampus

open access: yes, 1986
The effects of substance P, eledoisin and physalaemin--which are structurally similar and all belong to the tachykinin family--and of bombesin, a gastrin-releasing peptide, on non-pyramidal neurones were studied using unitary extracellular recordings ...
Dreifuss, Jean-Jacques   +1 more
core   +1 more source

Brain neuropeptides in central ventilatory and cardiovascular regulation in trout.

open access: yesFrontiers in Endocrinology, 2012
Many neuropeptides and their G-protein coupled receptors (GPCRs) are present within the brain area involved in ventilatory and cardiovascular regulation but only a few mammalian studies have focused on the integrative physiological actions of ...
Jean-Claude eLe Mével   +3 more
doaj   +1 more source

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