Results 31 to 40 of about 38,230 (233)

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Developing a Comprehensive Integrated Talent Management Strategy for a Tertiary Institution in South Africa

International Journal of Applied Research in Business and Management
This study is aimed at the development of a comprehensive integrated talent management strategy tailored to the unique context of tertiary institutions in South Africa.
Owen Zivanai Mukwawaya
doaj   +1 more source

Exploring talent management execution in the Ministry of Justice in the Namibian public sector

SA Journal of Human Resource Management, 2019
Orientation: The Ministry of Justice in the government of the Republic of Namibia, which is tasked to implement an effective judicial system in the country, is one of the public sector institutions rocked by a shortage of critical skills.
Kristofina Filippus, Cecilia M. Schultz
doaj   +1 more source

Introducing a Talent Management Model based on Grounded theory (Case Study: Telecom Operator) [PDF]

پژوهش‌های مدیریت عمومی, 2017
Extended Abstract Changing economic and technological paradigms, causes very significant issues in different industries, especially technology-laden ones, like telecom.
Ariyan Gholipor, Nayere Eftekhar
doaj   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

Impact of a senior research thesis on students' perceptions of scientific inquiry in distinct student populations

FEBS Open Bio, EarlyView.
This study addressed how a senior research thesis is perceived by undergraduate students. It assessed students' perception of research skills, epistemological beliefs, and career goals in Biochemistry (science) and BDC (science‐business) students. Completing a thesis improved confidence in research skills, resilience, scientific identity, closed gender‐
Celeste Suart, Haley L. Zubyk, Michelle Ogrodnik, Caitlin E. Mullarkey, Felicia Vulcu   +4 more
wiley   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Impact of contextual factors on organisational performance mediated by talent management

SA Journal of Industrial Psychology
Orientation: Talent management has become a significant concept in human resource management because of the potential influence thereof on organisational performance in a competitive business environment.
Gladys B. Zake, Petronella Jonck, Anna-Marie Pelser   +2 more
doaj   +1 more source

Situational Judgment Tests as Measures of 21st Century Skills: Evidence across Europe and Latin America

Journal of Work and Organizational Psychology, 2019
Over the years, various governmental, employment, and academic organizations have identified a list of skills to successfully master the challenges of the 21st century.
Christoph N. Herde, Filip Lievens, Emily G. Solberg, Jan L. Harbaugh, Mark H. Strong, Gary J. Burkholder   +5 more
doaj   +1 more source