Results 71 to 80 of about 2,826 (173)

Tanycytic transcytosis inhibition disrupts energy balance, glucose homeostasis and cognitive function in male mice

Molecular Metabolism
Objectives: In Western society, high-caloric diets rich in fats and sugars have fueled the obesity epidemic and its related disorders. Disruption of the body-brain communication, crucial for maintaining glucose and energy homeostasis, arises from both ...
Manon Duquenne, Eleonora Deligia, Cintia Folgueira, Cyril Bourouh, Emilie Caron, Frank Pfrieger, Markus Schwaninger, Ruben Nogueiras, Jean-Sébastien Annicotte, Monica Imbernon, Vincent Prévot   +10 more
doaj   +1 more source

Identification of GK and GKRP isoforms expressed in tanycytes.

, 2014
A, GK sequences were amplified by RT-PCR using primers that were specific for pancreatic GK (856 bp; top panel), liver GK (388 bp; middle panel), and β-actin (353 bp; bottom panel).
Marcos Villagra (553132), Fernando Martínez (2485834), Estefanía Tarifeño-Saldivia (553128), María José Yañez (553131), Elena Uribe (553134), Patricio Ordenes (553129), Carola Millán (553130), María de los Angeles García-Robles (553135), Francisco Nualart (231550), Roberto Elizondo-Vega (553133), Magdiel Salgado (553127), Paula Llanos (231548)   +11 more
core   +1 more source

Neurodevelopmental origin and adult neurogenesis of the neuroendocrine hypothalamus

Frontiers in Cellular Neuroscience, 2015
The adult hypothalamus regulates many physiological functions and homeostatic loops, including growth, feeding and reproduction. In mammals, the hypothalamus derives from the ventral diencephalon where two distinct ventricular proliferative zones have ...
Roberto eMaggi, Jacopo eZasso, Luciano eConti   +2 more
doaj   +1 more source

Amino acid sensing in hypothalamic tanycytes via umami taste receptors [PDF]

Energy homeostasis is controlled in the hypothalamus. Hypothalamic tanycytes are a type of glial cell that lie in the wall of the third ventricle, between ventricular CSF and the key nuclei controlling feeding, and are potentially linked to this ...
Lazutkaite, Greta
core  

Taste receptors are our mediators in shaping the taste preferences of a child

Медицинский совет, 2018
The article presents modern data on the main molecular and genetic determinants of shaping the taste preferences. The authors present the structure and mechanism of the functioning of sweet taste receptors, umami taste, acidic and bitter tastes, as well ...
I. N. Zakharova, A. N. Kasyanova, Yu. А. Dmitrieva, Е. B. Machneva   +3 more
doaj   +1 more source

Rôle des tanycytes dans la clairance de Tau et leur pertinence dans la maladie d'Alzheimer

, 2022
La maladie d'Alzheimer (MA) est caractérisée par l'accumulation du peptide A-bêta et de la protéine tau dans le cerveau, provoquant une neurodégénérescence.
Sauvé, Florent
core   +1 more source

Insulin signalling in tanycytes gates hypothalamic insulin uptake and regulation of AgRP neuron activity

, 2021
Insulin acts on neurons and glial cells to regulate systemic glucose metabolism and feeding. However, the mechanisms of insulin access in discrete brain regions are incompletely defined.
Cremer, A., Backes, H., Cremer, A.L., Brüning, J.C., Klemm, P., Secher, A., Hausen, A., Jais, A., Hausen, A.C., Schwaninger, M., Pedersen, T., Brüning, J., Wunderlich, F., Kumar, M., Tao, J., Steuernagel, L., Wunderlich, F.T., Lowell, B., Lowell, B.B., Sundaram, S., Porniece Kumar, M.   +20 more
core   +1 more source

IMMUNOHISTOCHEMICAL EXPRESSION OF MONOCARBOXYLATE TRANSPORTER 1&4 IN TANYCYTE–LIKE CELLS OF THE SULCUS MEDIANUS ORGANUM

The Iraqi Journal of Medical Sciences, 2019
Background: Circumventricular organs (CVOs) are specialized structures border the brain ventricles and lack the blood-brain barrier. These CVOs are lined by specialized ependymal cells (ECs) called tanycyte.
Haider F. Jawad, Muthanna A. Al-Kaabi, Anam R. Al-Salihi   +2 more
doaj   +4 more sources

Hypothalamic Tanycytes Are an ERK-Gated Conduit for Leptin into the Brain

, 2014
SummaryLeptin secreted by adipocytes acts on the brain to reduce food intake by regulating neuronal activity in the mediobasal hypothalamus (MBH). Obesity is associated with resistance to high circulating leptin levels.
Rasika, S., Trinquet, Eric, Prévot, Vincent, Anouar, Youssef, Falluel-Morel, Anthony, Jockers, Ralf, Langlet, Fanny, Caron, Emilie, Balland, Eglantine, Bouret, Sebastien ,, Bouret, Sebastien G., Messina, Andrea, Steculorum, Sophie, Dehouck, Bénédicte, Bouret, Sebastien , G., Dam, Julie   +15 more
core   +1 more source

Polycystic Ovary Syndrome Pathophysiology: Integrating Systemic, CNS and Circadian Processes

Frontiers in Bioscience-Landmark
The conceptualization of polycystic ovary syndrome (PCOS) has primarily focused on hormonal alterations driven by changes within the hypothalamus and ovarian granulosa cells, with treatment by the contraceptive pill and weight loss.
George Anderson
doaj   +1 more source