Results 31 to 40 of about 653,941 (306)
Therapy of pancreatic cancer via an EphA2 receptor-targeted delivery of gemcitabine. [PDF]
, 2016 First line treatment for pancreatic cancer consists of surgical resection, if possible, and a subsequent course of chemotherapy using the nucleoside analogue gemcitabine.
Barile, Elisa +11 more
core +2 more sources
Journal of Controlled Release, 1993 Achieving adequate dosage of a drug to be effective, without crossing the line into toxicity, can be a problem. This paper reviews ongoing research into methods of delivering drugs only to diseased tissue or cells, minimally affecting surrounding tissue.
Lisa Brannon-Peppas, Nicholas A. Peppas
+6 more sources
Tumor-targeted delivery of siRNA using fatty acyl-CGKRK peptide conjugates
Scientific Reports, 2017 Tumor-targeted carriers provide efficient delivery of chemotherapeutic agents to tumor tissue. CGKRK is one of the well-known tumor targeting peptides with significant specificity for angiogenic blood vessels and tumor cells. Here, we designed fatty acyl
Meenakshi Sharma +5 more
doaj +1 more source
Molecules, 2020 Remdesivir is a nucleotide prodrug that is currently undergoing extensive clinical trials for the treatment of COVID-19. The prodrug is metabolized to its active triphosphate form and interferes with the action of RNA-dependent RNA polymerase of SARS-COV-
Keykavous Parang +3 more
doaj +1 more source
Synthetic cells with self-activating optogenetic proteins communicate with natural cells
Nature Communications, 2022 Synthetic biology and engineering approaches are harnessed to incorporate new capabilities in synthetic cells. Here, the authors designed bioluminescent signaling mechanisms for intracellular and intercellular synthetic-to-natural cell communication.
Omer Adir +15 more
doaj +1 more source
Synthesis of a novel PEGylated colon-specific azo-based 4- aminosalicylic acid prodrug [PDF]
Iranian Journal of Basic Medical Sciences, 2020 Objective(s): 4-aminosalicylic acid (4-ASA) is an isomer of mesalazine that has recently been shown to be effective against inflammatory bowel disease (IBD), and more specifically, ulcerative colitis. However, the majority of orally administered 4-ASA is
Fatemeh Sadeghi +5 more
doaj +1 more source
Molecules, 2019 Cell-penetrating peptide [WR]5 has been previously shown to be an efficient molecular transporter for various hydrophilic and hydrophobic molecules. The peptide was synthesized using Fmoc/tBu solid-phase chemistry, and one arginine was replaced with one ...
Naglaa Salem El-Sayed +5 more
doaj +1 more source
In search of elixir: Pharmacological agents against stem cell senescence [PDF]
Iranian Journal of Basic Medical Sciences, 2021 Stem cell senescence causes different complications. In addition to the aging phenomenon, stem cell senescence has been investigated in various concepts such as cancer, adverse drug effects, and as a limiting factor in cell therapy.
Hourieh Tousian +2 more
doaj +1 more source
The Use of Poly(vinyl alcohol)-based Hydrogels in Biomedical Applications [PDF]
, 2018 Polymers have found increasing favor in biomedical applications due to the greater control that researchers can exert over their properties. Researchers have focused on the development of therapies using biologically compatible polymers due to their ...
Subramanian, Deepak
core +1 more source
Molecules, 2018 Linear (HR)n and cyclic [HR]n peptides (n = 4,5) containing alternate arginine and histidine residues were synthesized. The peptides showed 0–15% cytotoxicity at 5–100 µM in human ovarian adenocarcinoma (SK-OV-3) cells while they ...
Naglaa Salem El-Sayed +7 more
doaj +1 more source