Results 41 to 50 of about 653,941 (306)

Aptamer-modified polymer nanoparticles for targeted drug delivery [PDF]

, 2016
The purpose of this study was to develop a model system for targeted drug delivery. This system should enable targeted drug release at a certain tissue in the body. In conventional drug delivery systems, drugs are often delivered unspecifically resulting
Belhadj, Hamza, Blume, Cornelia, Green, Mark, Kemal, Evren, Kretschmer, Imme, Modrejewski, Julia, Scheper, Thomas, Walter, Johanna-Gabriela   +7 more
core   +2 more sources

Overcoming Barriers for siRNA Therapeutics: From Bench to Bedside

Pharmaceuticals, 2020
The RNA interference (RNAi) pathway possesses immense potential in silencing any gene in human cells. Small interfering RNA (siRNA) can efficiently trigger RNAi silencing of specific genes.
Muhammad Imran Sajid, Muhammad Moazzam, Shun Kato, Kayley Yeseom Cho, Rakesh Kumar Tiwari   +4 more
doaj   +1 more source

Multifunctional targeting micelle nanocarriers with both imaging and therapeutic potential for bladder cancer. [PDF]

, 2012
BackgroundWe previously developed a bladder cancer-specific ligand (PLZ4) that can specifically bind to both human and dog bladder cancer cells in vitro and in vivo. We have also developed a micelle nanocarrier drug-delivery system.
de Vere White, Ralph, Gao, Tingjuan, Lam, Kit S, Lara, Primo N, Li, Yuanpei, Lin, Tzu-Yin, Luo, Juntao, Pan, Chong-Xian, Zhang, Hongyong   +8 more
core   +2 more sources

Efficient Intracellular Delivery of Cell-Impermeable Cargo Molecules by Peptides Containing Tryptophan and Histidine

Molecules, 2018
We have previously evaluated and reported numerous classes of linear and cyclic peptides containing hydrophobic and hydrophilic segments for intracellular delivery of multiple molecular cargos.
Amir Nasrolahi Shirazi, Saghar Mozaffari, Rinzhin Tshering Sherpa, Rakesh Tiwari, Keykavous Parang   +4 more
doaj   +1 more source

Cyclic Peptide-Gadolinium Nanocomplexes as siRNA Delivery Tools

Pharmaceuticals, 2021
We have recently reported that a cyclic peptide containing five tryptophan, five arginine, and one cysteine amino acids [(WR)5C], was able to produce peptide-capped gadolinium nanoparticles, [(WR)5C]-GdNPs, in the range of 240 to 260 nm upon mixing with ...
Amir Nasrolahi Shirazi, Muhammad Imran Sajid, Dindyal Mandal, David Stickley, Stephanie Nagasawa, Joshua Long, Sandeep Lohan, Keykavous Parang, Rakesh Kumar Tiwari   +8 more
doaj   +1 more source

Numerical simulation of solid tumor blood perfusion and drug delivery during the “vascular normalization window” with antiangiogenic therapy [PDF]

, 2011
This Article is provided by the Brunel Open Access Publishing Fund - Copyright @ 2011 Hindawi PublishingTo investigate the influence of vascular normalization on solid tumor blood perfusion and drug delivery, we used the generated blood vessel network ...
Cai, Y, Cao, J, Long, Q, Lv, J, Xu, S, Yao, W, Zhou, Y   +6 more
core   +2 more sources

Comparative Molecular Transporter Properties of Cyclic Peptides Containing Tryptophan and Arginine Residues Formed through Disulfide Cyclization

Molecules, 2020
We have previously reported cyclic cell-penetrating peptides [WR]5 and [WR]4 as molecular transporters. To optimize further the utility of our developed peptides for targeted therapy in cancer cells using the redox condition, we designed a new generation
Eman H. M. Mohammed, Dindyal Mandal, Saghar Mozaffari, Magdy Abdel-Hamied Zahran, Amany Mostafa Osman, Rakesh Kumar Tiwari, Keykavous Parang   +6 more
doaj   +1 more source

Aptamer mediated niosomal drug delivery [PDF]

, 2016
Development of nanoscale carrier systems for targeted drug delivery is crucial for cancer treatment. The current methods of drug delivery exhibit some problems such as lack of therapy efficiency at the desired parts of the body, degradation of the drug ...
Jochums, André, Scheper, Thomas, Seleci, Didem Ag, Seleci, Muharrem, Stahl, Frank, Walter, Johanna-Gabriela   +5 more
core   +2 more sources

targeted drug delivery

Citation: 'targeted drug delivery' in the IUPAC Compendium of Chemical Terminology, 5th ed.; International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.12732 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms ...
Sheena Mariam Thomas, Ramakrishnan Veerabathiran   +1 more
  +4 more sources

Cyclic Peptide-Gadolinium Nanoparticles for Enhanced Intracellular Delivery

Pharmaceutics, 2020
A cyclic peptide containing one cysteine and five alternating tryptophan and arginine amino acids [(WR)5C] was synthesized using Fmoc/tBu solid-phase methodology.
Amir Nasrolahi Shirazi, Shang Eun Park, Shirin Rad, Luiza Baloyan, Dindyal Mandal, Muhammad Imran Sajid, Ryley Hall, Sandeep Lohan, Khalid Zoghebi, Keykavous Parang, Rakesh Kumar Tiwari   +10 more
doaj   +1 more source