Results 1 to 10 of about 27,856 (310)

Tau Protein Hyperphosphorylation and Aggregation in Alzheimer’s Disease and Other Tauopathies, and Possible Neuroprotective Strategies [PDF]

Biomolecules, 2016
Acknowledgments This work was supported by The Croatian Science Foundation grant No. IP-2014-09-9730 (“Tau protein hyperphosphorylation, aggregation, and trans-synaptic transfer in Alzheimer’s disease: cerebrospinal fluid analysis and assessment of ...
Goran Šimić, Mirjana Babić Leko, Selina Wray   +2 more
exaly   +7 more sources

Specific post-translational modifications of soluble tau protein distinguishes Alzheimer’s disease and primary tauopathies [PDF]

Nature Communications, 2023
Tau protein aggregates in several neurodegenerative disorders, referred to as tauopathies. The tau isoforms observed in post mortem human brain aggregates is used to classify tauopathies.
Nathalie Kyalu Ngoie Zola, Clémence Balty, Sébastien Pyr dit Ruys, Axelle A. T. Vanparys, Nicolas D. G. Huyghe, Gaëtan Herinckx, Manuel Johanns, Emilien Boyer, Pascal Kienlen-Campard, Mark H. Rider, Didier Vertommen, Bernard J. Hanseeuw   +11 more
doaj   +2 more sources

Tau and neuroinflammation: What impact for Alzheimer's Disease and Tauopathies?

Biomedical Journal, 2018
Alzheimer's Disease (AD) is a chronic neurodegenerative disorder and the most common type of dementia (60–80% of cases). In 2016, nearly 44 million people were affected by AD or related dementia.
Luc Buee, David Blum
exaly   +3 more sources

Tau deposition patterns are associated with functional connectivity in primary tauopathies

Nature Communications, 2022
Tau pathology drives neuronal dysfunction in 4- repeat tauopathies. Here, the authors combine tau-PET, resting-state fMRI and histopathology data, to show that brain connectivity is associated with tau deposition patterns in 4-repeat tauopathies.
Nicolai Franzmeier, Matthias Brendel, Leonie Beyer   +2 more
exaly   +2 more sources

Neurodegeneration in tauopathies and synucleinopathies [PDF]

, 2016
While increasing life expectancy is a major achievement, the global aging of societies raises a number of medical issues, such as the development of age-related disorders, including neurodegenerative diseases.
Foguem, Clovis, Kamsu-Foguem, Bernard
core   +6 more sources

Tauopathies: Calmodulin Regulates Tau Hyperphosphorylation and Its Transformation into Disease-Specific Aggregates [PDF]

Biomolecules
Tauopathies are a diverse group of neurodegenerative diseases characterized by the presence of Tau inclusions in neurons and glia. Rather than the classic steps in the transformation of Tau into neurofibrillary tangles, as first studied in Alzheimer’s ...
Danton H. O’Day
doaj   +2 more sources

Unlocking the Sugar Code: Implications and Consequences of Glycosylation in Alzheimer's Disease and Other Tauopathies. [PDF]

Biomedicines
Bondar AC, Iordache MP, Coroescu M, Buliman A, Rusu E, Budișteanu M, Tanase C.   +6 more
europepmc   +3 more sources

Pharmacological management of tauopathies [PDF]

Alzheimers Dement
Rioja R, Morales‐Rivero A, Cordero I, Kovacs G, Tartaglia C, Couto B.   +5 more
europepmc   +3 more sources

Early-Life Environment Influence on Late-Onset Alzheimer’s Disease

Frontiers in Cell and Developmental Biology, 2022
With the expand of the population’s average age, the incidence of neurodegenerative disorders has dramatically increased over the last decades. Alzheimer disease (AD) which is the most prevalent neurodegenerative disease is mostly sporadic and primarily ...
Thibaut Gauvrit, Thibaut Gauvrit, Hamza Benderradji, Hamza Benderradji, Luc Buée, Luc Buée, David Blum, David Blum, Didier Vieau, Didier Vieau   +9 more
doaj   +1 more source

DNA Methylation in Genetic and Sporadic Forms of Neurodegeneration: Lessons from Alzheimer’s, Related Tauopathies and Genetic Tauopathies

Cells, 2021
Genetic and sporadic forms of tauopathies, the most prevalent of which is Alzheimer’s Disease, are a scourge of the aging society, and in the case of genetic forms, can also affect children and young adults.
Geraldine Zimmer-Bensch, Hans Zempel
doaj   +1 more source