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Astrocytes in Tauopathies [PDF]

Frontiers in Neurology, 2020
Tauopathies are a group of neurodegenerative diseases characterized by the progressive accumulation across the brain of hyperphosphorylated aggregates of the microtubule-associated protein tau that vary in isoform composition, structural conformation and
Matthew J. Reid, Paula Beltran-Lobo, Louisa Johnson, Beatriz Gomez Perez-Nievas, Wendy Noble   +4 more
doaj   +5 more sources

Tauopathies: new perspectives and challenges

Molecular Neurodegeneration, 2022
Background Tauopathies are a class of neurodegenerative disorders characterized by neuronal and/or glial tau-positive inclusions. Main body Clinically, tauopathies can present with a range of phenotypes that include cognitive/behavioral-disorders ...
Qiang Dong, Jin-Tai Yu
exaly   +2 more sources

Oxidative Stress in Tauopathies: From Cause to Therapy

Antioxidants, 2022
Oxidative stress (OS) is the result of an imbalance between the production of reactive oxygen species (ROS) and the antioxidant capacity of cells. Due to its high oxygen demand, the human brain is highly susceptible to OS and, thus, it is not a surprise ...
Fernando Bartolomé-Robledo, Eva Carro, Carolina Alquezar   +2 more
exaly   +3 more sources

Neurodegenerative Disease Tauopathies

Annual Review of Pathology: Mechanisms of Disease
Tauopathies are a diverse group of progressive and fatal neurodegenerative diseases characterized by aberrant tau inclusions in the central nervous system. Tau protein forms pathologic fibrillar aggregates that are typically closely associated with neuronal cell death, leading to varied clinical phenotypes including dementia, movement disorders, and ...
Creekmore, Benjamin C., Watanabe, Ryohei, Lee, Edward B.   +2 more
exaly   +3 more sources

Early-Life Environment Influence on Late-Onset Alzheimer’s Disease

Frontiers in Cell and Developmental Biology, 2022
With the expand of the population’s average age, the incidence of neurodegenerative disorders has dramatically increased over the last decades. Alzheimer disease (AD) which is the most prevalent neurodegenerative disease is mostly sporadic and primarily ...
Thibaut Gauvrit, Thibaut Gauvrit, Hamza Benderradji, Hamza Benderradji, Luc Buée, Luc Buée, David Blum, David Blum, Didier Vieau, Didier Vieau   +9 more
doaj   +1 more source

DNA Methylation in Genetic and Sporadic Forms of Neurodegeneration: Lessons from Alzheimer’s, Related Tauopathies and Genetic Tauopathies

Cells, 2021
Genetic and sporadic forms of tauopathies, the most prevalent of which is Alzheimer’s Disease, are a scourge of the aging society, and in the case of genetic forms, can also affect children and young adults.
Geraldine Zimmer-Bensch, Hans Zempel
doaj   +1 more source

Rare Tauopathies [PDF]

Seminars in Neurology, 2019
Tauopathies are rare neurodegenerative disorders related to microtubule-associated protein tau, which functions to stabilize microtubules. Pathological changes caused by overexpression or hyperphosphorylation of tau lead to the disengagement of tau from microtubules and accumulation of toxic intracellular inclusions.
Farwa, Ali, Keith, Josephs
openaire   +2 more sources

Impaired Glucose Homeostasis in a Tau Knock-In Mouse Model

Frontiers in Molecular Neuroscience, 2022
Alzheimer’s disease (AD) is the leading cause of dementia. While impaired glucose homeostasis has been shown to increase AD risk and pathological loss of tau function, the latter has been suggested to contribute to the emergence of the glucose ...
Hamza Benderradji, Hamza Benderradji, Sarra Kraiem, Sarra Kraiem, Emilie Courty, Sabiha Eddarkaoui, Sabiha Eddarkaoui, Cyril Bourouh, Emilie Faivre, Emilie Faivre, Laure Rolland, Emilie Caron, Emilie Caron, Mélanie Besegher, Frederik Oger, Theo Boschetti, Theo Boschetti, Kévin Carvalho, Kévin Carvalho, Bryan Thiroux, Bryan Thiroux, Thibaut Gauvrit, Thibaut Gauvrit, Emilie Nicolas, Victoria Gomez-Murcia, Victoria Gomez-Murcia, Anna Bogdanova, Anna Bogdanova, Antonino Bongiovanni, Anne Muhr-Tailleux, Steve Lancel, Kadiombo Bantubungi, Nicolas Sergeant, Nicolas Sergeant, Jean-Sebastien Annicotte, Luc Buée, Luc Buée, Didier Vieau, Didier Vieau, David Blum, David Blum, Valérie Buée-Scherrer, Valérie Buée-Scherrer   +42 more
doaj   +1 more source

Immunotherapy for Tauopathies [PDF]

Journal of Molecular Neuroscience, 2011
Pathological tau protein is found in Alzheimer's disease and related tauopathies. The protein is hyperphosphorylated and/or mutated which leads to aggregation and neurotoxicity. Because cognitive functions correlate well with the degree of tau pathology, clearing these aggregates is a promising therapeutic approach.
Jiaping, Gu, Einar M, Sigurdsson
openaire   +2 more sources

Tau Stabilizes Chromatin Compaction

Frontiers in Cell and Developmental Biology, 2021
An extensive body of literature suggested a possible role of the microtubule-associated protein Tau in chromatin functions and/or organization in neuronal, non-neuronal, and cancer cells. How Tau functions in these processes remains elusive.
Thomas Rico, Melissa Gilles, Alban Chauderlier, Thomas Comptdaer, Romain Magnez, Maggy Chwastyniak, Herve Drobecq, Florence Pinet, Xavier Thuru, Luc Buée, Marie-Christine Galas, Bruno Lefebvre   +11 more
doaj   +1 more source