Results 11 to 20 of about 12,857 (194)
Nature Communications, 2023 Tau protein aggregates in several neurodegenerative disorders, referred to as tauopathies. The tau isoforms observed in post mortem human brain aggregates is used to classify tauopathies.
Nathalie Kyalu Ngoie Zola +11 more
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Cellular and pathological heterogeneity of primary tauopathies
Molecular Neurodegeneration, 2021 Microtubule-associated protein tau is abnormally aggregated in neuronal and glial cells in a range of neurodegenerative diseases that are collectively referred to as tauopathies.
Dah-eun Chloe Chung +3 more
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Different tau species lead to heterogeneous tau pathology propagation and misfolding
Acta Neuropathologica Communications, 2018 Tauopathies are a heterogeneous group of pathologies characterized by tau aggregation inside neurons. Most of them are sporadic but certain tauopathies rely on tau gene (MAPT) mutations.
Simon Dujardin +13 more
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Tau and neuroinflammation: What impact for Alzheimer's Disease and Tauopathies?
Biomedical Journal, 2018 Alzheimer's Disease (AD) is a chronic neurodegenerative disorder and the most common type of dementia (60–80% of cases). In 2016, nearly 44 million people were affected by AD or related dementia.
Cyril Laurent, Luc Buée, David Blum
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Cellular and Molecular Life Sciences, 2007 Tau is a microtubule-associated protein predominantly expressed in nerve cells that promote microtubule assembly and microtubule stabilization. Tau is a cytosolic protein mainly present in axons and involved in anterograde axonal transport. In several neurodegenerative diseases, as for example Alzheimer's disease, tau metabolism is altered.
Hernández, Félix, Ávila, Jesús
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Tau deposition patterns are associated with functional connectivity in primary tauopathies
Nature Communications, 2022 Tau pathology drives neuronal dysfunction in 4- repeat tauopathies. Here, the authors combine tau-PET, resting-state fMRI and histopathology data, to show that brain connectivity is associated with tau deposition patterns in 4-repeat tauopathies.
Nicolai Franzmeier +59 more
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Novel monoclonal antibodies targeting the microtubule-binding domain of human tau. [PDF]
PLoS ONE, 2018 Tauopathies including Alzheimer's disease and Progressive Supranuclear Palsy are a diverse group of progressive neurodegenerative disorders pathologically defined by inclusions containing aberrantly aggregated, post-translationally modified tau.
Cara L Croft +6 more
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Pneumonia initiates a tauopathy [PDF]
The FASEB Journal, 2021 Abstract Pneumonia causes short‐ and long‐term cognitive dysfunction in a high proportion of patients, although the mechanism(s) responsible for this effect are unknown. Here, we tested the hypothesis that pneumonia‐elicited cytotoxic amyloid and tau variants: (1) are present in the circulation during infection; (2) lead to impairment
Ron Balczon +15 more
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Critical Molecular and Cellular Contributors to Tau Pathology
Biomedicines, 2021 Tauopathies represent a group of neurodegenerative diseases including Alzheimer’s disease (AD) that are characterized by the deposition of filamentous tau aggregates in the brain.
Liqing Song +2 more
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Tauopathy and Movement Disorders—Unveiling the Chameleons and Mimics
Frontiers in Neurology, 2020 The spectrum of tauopathy encompasses heterogenous group of neurodegenerative disorders characterized by neural or glial deposition of pathological protein tau. Clinically they can present as cognitive syndromes, movement disorders, motor neuron disease,
Jacky Ganguly, Mandar Jog
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