Results 11 to 20 of about 27,856 (310)
Astrocytes in Tauopathies [PDF]
Frontiers in Neurology, 2020 Tauopathies are a group of neurodegenerative diseases characterized by the progressive accumulation across the brain of hyperphosphorylated aggregates of the microtubule-associated protein tau that vary in isoform composition, structural conformation and
Matthew J. Reid +4 more
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Oxidative Stress in Tauopathies: From Cause to Therapy
Antioxidants, 2022 Oxidative stress (OS) is the result of an imbalance between the production of reactive oxygen species (ROS) and the antioxidant capacity of cells. Due to its high oxygen demand, the human brain is highly susceptible to OS and, thus, it is not a surprise ...
Fernando Bartolome +2 more
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Seminars in Neurology, 2019 Tauopathies are rare neurodegenerative disorders related to microtubule-associated protein tau, which functions to stabilize microtubules. Pathological changes caused by overexpression or hyperphosphorylation of tau lead to the disengagement of tau from microtubules and accumulation of toxic intracellular inclusions.
Farwa, Ali, Keith, Josephs
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Impaired Glucose Homeostasis in a Tau Knock-In Mouse Model
Frontiers in Molecular Neuroscience, 2022 Alzheimer’s disease (AD) is the leading cause of dementia. While impaired glucose homeostasis has been shown to increase AD risk and pathological loss of tau function, the latter has been suggested to contribute to the emergence of the glucose ...
Hamza Benderradji +42 more
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Tauopathies: new perspectives and challenges
Molecular Neurodegeneration, 2022 Background Tauopathies are a class of neurodegenerative disorders characterized by neuronal and/or glial tau-positive inclusions. Main body Clinically, tauopathies can present with a range of phenotypes that include cognitive/behavioral-disorders ...
Yi Zhang +4 more
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Immunotherapy for Tauopathies [PDF]
Journal of Molecular Neuroscience, 2011 Pathological tau protein is found in Alzheimer's disease and related tauopathies. The protein is hyperphosphorylated and/or mutated which leads to aggregation and neurotoxicity. Because cognitive functions correlate well with the degree of tau pathology, clearing these aggregates is a promising therapeutic approach.
Jiaping, Gu, Einar M, Sigurdsson
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Tau Stabilizes Chromatin Compaction
Frontiers in Cell and Developmental Biology, 2021 An extensive body of literature suggested a possible role of the microtubule-associated protein Tau in chromatin functions and/or organization in neuronal, non-neuronal, and cancer cells. How Tau functions in these processes remains elusive.
Thomas Rico +11 more
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Long-term in vivo imaging of fibrillar tau in the retina of P301S transgenic mice. [PDF]
, 2012 Tauopathies are widespread neurodegenerative disorders characterised by the intracellular accumulation of hyperphosphorylated tau. Especially in Alzheimer's disease, pathological alterations in the retina are discussed as potential biomarkers to improve ...
Arzberger, Thomas +11 more
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Cellular and pathological heterogeneity of primary tauopathies
Molecular Neurodegeneration, 2021 Microtubule-associated protein tau is abnormally aggregated in neuronal and glial cells in a range of neurodegenerative diseases that are collectively referred to as tauopathies.
Dah-eun Chloe Chung +3 more
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Different tau species lead to heterogeneous tau pathology propagation and misfolding
Acta Neuropathologica Communications, 2018 Tauopathies are a heterogeneous group of pathologies characterized by tau aggregation inside neurons. Most of them are sporadic but certain tauopathies rely on tau gene (MAPT) mutations.
Simon Dujardin +13 more
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