Results 121 to 130 of about 31,353 (262)

Soluble tau species, not neurofibrillary aggregates, disrupt neural system integration in a tau transgenic model [PDF]

, 2011
Neurofibrillary tangles are a feature of Alzheimer disease and other tauopathies, and while they are generally believed to be markers of neuronal pathology, there is little evidence evaluating whether tangles directly impact neuronal function.
Adamowicz, David H, Carlson, George A, Fox, Leora M, Hyman, Bradley T, Pitstick, Rose, Spires-Jones, Tara L, William, Christopher M   +6 more
core   +1 more source

Integrative physiology of skeletal muscle for maintaining cognitive health

The Journal of Physiology, EarlyView.
Abstract figure legend Maintenance of brain/cognitive health and function is increasingly appreciated to be a systemic challenge. In particular, skeletal muscle influences the brain through release of myokines in response to contraction, which influence the expression of brain‐derived neurotrophic factor (BDNF) in the brain, a vital player in the ...
Matthew H. Brisendine, Joshua C. Drake
wiley   +1 more source

Investigation of the pharmacological activity of the tetrapeptide HAEЕ, zinc, and human serum albumin in a transgenic mouse model with tau protein overexpression (P301S)

Research Results in Pharmacology
Introduction: Neurodegenerative diseases affecting neurons represent a wide spectrum of pathological conditions. To slow the accumulation of pathological tau protein, therapeutic interventions such as a pharmaceutical composition consisting of the ...
Veronika S. Shmigerova, Yulia V. Stepenko, Alexandra A. Kurbatova, Nikita S. Zhunusov, Nikita S. Lyapkalov, Maria S. Sviridova, Tatyana V. Avtina, Arkadiy V. Nesterov, Alexander A. Popov, Natalia I. Nesterova, Mariia Iu. Goltsova, Tatiana G. Pokrovskaya   +11 more
doaj   +1 more source

Testing a MultiTEP-based combination vaccine to reduce Aβ and tau pathology in Tau22/5xFAD bigenic mice. [PDF]

, 2019
BackgroundAlzheimer disease (AD) is characterized by the accumulation of beta-amyloid (Aβ) plaques and neurofibrillary tangles composed of hyperphosphorylated tau, which together lead to neurodegeneration and cognitive decline.
Agadjanyan, Michael G, Antonyan, Tatevik, Blurton-Jones, Mathew, Chailyan, Gor, Coburn, Morgan A, Cribbs, David H, Danhash, Emma, Davtyan, Hayk, Ghochikyan, Anahit, Hovakimyan, Armine, Kiani Shabestari, Sepideh, Petrovsky, Nikolai, Petrushina, Irina, Svystun, Olga, Zagorski, Karen   +14 more
core  

Tauopathies, motricité et cognition [Tauopathy, motricity and cognition]

, 2023
The tauopathies are one of the families of proteinopathies causing neurodegenerative diseases. They are characterized by a combination of cognitive and motor disorders. In this article, we summarize the clinical features of progressive supranuclear palsy and cortico-basal degeneration, focusing on their cognitive-behavioral impairment profiles, which ...
Kermorvant, H., Castro-Jimenez, M., Allali, G., Bally, J.F.   +3 more
openaire   +1 more source

Nutritional Value and Memory‐Improving Effects of Seven Major Nuts: A Comprehensive Study Using Network Pharmacology and In Vivo Assays

Food Frontiers, Volume 7, Issue 2, March 2026.
This study highlights the memory‐enhancing effects of walnuts, almonds, and Torreya, with walnuts showing the strongest potential to improve cognitive function and delay brain aging. ABSTRACT This study explored the memory‐enhancing potential of seven commercially available nuts through nutritional profiling, metabolomics, network pharmacology, and ...
Jiamin Chen, Ben Niu, Ruiling Liu, Chaoyi Shen, Huizhi Chen, Mohamed A. Farag, Hangjun Chen, Qi Chen, Long Jin, Weijie Wu, Haiyan Gao   +10 more
wiley   +1 more source

Dissecting the microglial response in transgenic models of amyloidogenesis and tauopathy [PDF]

, 2019
Amyloid-beta (Abeta) peptide deposits and hyperphosphorylated tau protein (phospho-tau) accumulate in Alzheimer’s disease (AD) brains. These abnormal protein aggregates leads to glial activation, synaptic dysfunction, neuronal loss and cognitive ...
Davila, Jose Carlos, Fernandez Valenzuela, Juan José, Gomez-Arboledas, Angela, Gutierrez-Perez, Antonia, Navarro, Victoria, Nuñez-Diaz, Cristina, Romero-Molina, Carmen, Sanchez-Mejias, Elisabeth, Sanchez-Varo, Raquel, Vitorica, Javier   +9 more
core  

Altered intrinsic pyramidal neuron properties and pathway-specific synaptic dysfunction underlie aberrant hippocampal network function in a mouse model of Tauopathy. [PDF]

, 2016
Final published version of article. This article is freely available online through the J Neurosci Author Open Choice option.The formation and deposition of tau protein aggregates is proposed to contribute to cognitive impairments in dementia by ...
Booth, Clair A., Brown, JT, Jones, MW, Nowacki, J, Randall, AD, Tsaneva-Atanasova, Krasimira, Witton, J   +6 more
core   +2 more sources

A unified 3D reconstruction of microscopy and MRI in a brain showing Alzheimer's disease‐related neuropathology

Brain Pathology, Volume 36, Issue 2, March 2026.
Post mortem MRI was combined with neuropathological assessments at 600 μm intervals throughout the brain. Through this approach, a three dimensional account of an entire human brain with an intermediate Alzheimer's disease neuropathologic change was created.
Anneke Alkemade, Pierre‐Louis Bazin, Evgeniya Kirilina, Kerrin Pine, Andreas Herrler, Ronald L. A. W. Bleijs, J. Max Kros, Lysanne Groenewegen, Sanne M. M. Vermorgen, Laura E. Jonkman, Dick F. Swaab, Rawien Balesar, Nikolaus Weiskopf, Birte U. Forstmann   +13 more
wiley   +1 more source

Sialylation patterns in cerebral amyloid angiopathy

Brain Pathology, Volume 36, Issue 2, March 2026.
This study is the first to localize and evaluate sialylation modifications in the context of Alzheimer's Disease and Cerebral Amyloid Angiopathy, revealing a unique disease‐specific increase in intravascular sialylation. Abstract Glycosylation is the most common form of post‐translational modification in the brain and becomes significantly altered in ...
Caitlyn Fastenau, Rebecca Crisp, Mallory Keating, Elizabeth Ochoa, Timothy E. Richardson, Margaret E. Flanagan, Jamie M. Walker, Sarah C. Hopp, Kevin F. Bieniek   +8 more
wiley   +1 more source