Results 141 to 150 of about 31,353 (262)

Olfactory‐to‐Entorhinal Network Dysrhythmias Drive Parkinson's Cognitive Impairment Through Frequency‐Specific Oscillatory Decoupling

Advanced Science, Volume 13, Issue 9, 13 February 2026.
Wang et al reveal that in the olfactory system, the selective impairment of gamma‐driven Barcode features underlying early olfactory deficits, while the selective impairment of theta‐driven Barcode features underlying later cognitive deficits, further establishing cross‐network gamma oscillations in the early stage as a biomarker of later cognitive ...
Shuaishuai Wang, Zhishen Cai, Xingfeng Mao, Yixuan Zhang, Yunlong Pan, Jiawen Cheng, Xuechun Wang, Hengyi Song, Sasaki Takuya, Ming Lu, Gang Hu, Xiuxiu Liu, Yingmei Lu, Feng Han   +13 more
wiley   +1 more source

SKALE: An Interpretable Multiscale Machine Learning Model for Decoding Phase‐Specific Protein Aggregation in Neurodegenerative Proteinopathies

Aggregate, Volume 7, Issue 2, February 2026.
Protein aggregation drives diverse degenerative diseases, yet its molecular origins are difficult to predict. SKALE uses interpretable machine learning to link sequence, structure, and dynamics, revealing how local structural weakening triggers aggregation.
Wei Xuan Wilson Loo, Jia Shen Sio, Keyin Yap, Yan Shan Loo, Hui Xuan Lim, Shuangyue Zhang, Huitao Liu, Chen Seng Ng   +7 more
wiley   +1 more source

Tau seeding without tauopathy

Journal of Biological Chemistry
Neurodegenerative tauopathies such as Alzheimer's disease (AD) are caused by brain accumulation of tau assemblies. Evidence suggests tau functions as a prion, and cells and animals can efficiently propagate unique, transmissible tau pathologies. This suggests a dedicated cellular replication machinery, potentially reflecting a normal physiologic ...
Michael S. LaCroix, Efrosini Artikis, Brian D. Hitt, Joshua D. Beaver, Sandi-Jo Estill-Terpack, Kelly Gleason, Carol A. Tamminga, Bret M. Evers, Charles L. White, Byron Caughey, Marc I. Diamond   +10 more
openaire   +2 more sources

Multiomic single nuclei profiling the mouse hippocampus reveals that ACSS2 confers neuronal resilience to tauopathy

Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract INTRODUCTION Epigenomic dysregulation contributes to Alzheimer's disease (AD) and related tauopathies. Acetyl‐CoA synthetase 2 (ACSS2), a nuclear‐localized metabolic enzyme in neurons, supports histone acetylation and learning‐related gene expression.
Gabor Egervari, Desi C. Alexander, Hua Huang, Greg Donahue, Connor Hogan, Mariel Mendoza, Hong Xu, Virginia Lee, Ben Garcia, Nancy Bonini, Shelley Berger   +10 more
wiley   +1 more source

Elevated temporal tau PET predicts faster cognitive decline in women than men: A meta‐analysis

Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract INTRODUCTION Women show higher levels of Alzheimer's disease (AD) pathology than men, but the implications for cognitive decline remain unclear. Determining the extent to which tau burden differentially accelerates cognitive decline in men and women will provide critical insights into sex‐specific pathways of disease progression.
Annie Li, Hannah M. Klinger, Mabel Seto, Colin Birkenbihl, Michael J. Properzi, Michelle Farrell, Emma Thibault, Aaron P. Schultz, Diana L. Townsend, Madison Cuppels, Jane A. Brown, Kathryn V. Papp, Rebecca E. Amariglio, Hyun‐Sik Yang, Michael C. Donohue, Robert A. Rissman, Tobey J. Betthauser, Rebecca E. Langhough, Erin M. Jonaitis, Karly Cody, Sterling C. Johnson, Dorene M. Rentz, Keith A. Johnson, Reisa A. Sperling, Rachel F. Buckley, Gillian T. Coughlan, the A4 Study Team   +26 more
wiley   +1 more source

Sex‐specific acceleration of Alzheimer's pathogenesis by chronic sleep‐deprivation

Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract INTRODUCTION Sleep impairments likely contribute to Alzheimer's pathology, though specific contributions to disease progression are incompletely understood. We propose that autophagic impairment is associated with chronic sleep disruption and examine how sleep loss and stress influence disease development, including having impacts on ...
Darcy Wear, Christopher Daniel Morrone, Dominic Simpson, Fang Liu, Syed Abid Hussaini, Wai Haung Yu   +5 more
wiley   +1 more source

Greater locus coeruleus vulnerability in atypical clinicopathologic forms of Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract INTRODUCTION The locus coeruleus (LC) degenerates early in Alzheimer's disease (AD). However, the extent of rostrocaudal degeneration across clinicopathologic heterogeneity remains underexplored in AD. METHODS Using digital pathology, we quantified LC neuronal density and area at three neuroanatomic levels in a large AD series.
Sara Rose Dunlop, Billie J. Matchett, Alexander F. Mannsbart, Fadi S. Hanna Al‐Shaikh, Zhongwei Peng, Darren M. Rothberg, Jessica F. Tranovich, Ranjan Duara, Idaly Velez Uribe, Joselen Gondrez, Rickey E. Carter, Tanis J. Ferman, Gregory S. Day, Neill R. Graff‐Radford, Dennis W. Dickson, Lea T. Grinberg, Melissa E. Murray   +16 more
wiley   +1 more source

NRN1 as a therapeutic target for Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract INTRODUCTION Neuritin‐1 (NRN1) was identified as a synaptic protein associated with cognitive resilience to Alzheimer's disease (AD). METHODS Target risk score and cell type expression profiles were generated for NRN1 using methods developed by the Emory‐Sage‐SGC‐JAX Target Enablement to Accelerate Therapy Development for Alzheimer's Disease ...
Derian A. Pugh, Gregory A. Cary, Kelsey M. Greathouse, Lauren C. Nassour‐Caswell, Emma L. Hobby, Nicholas T. Seyfried, Jeremy H. Herskowitz   +6 more
wiley   +1 more source

High vulnerability of medial prefrontal pyramidal neurons in post‐stroke, vascular, Alzheimer's disease, and aging‐related dementias

Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract INTRODUCTION The medial prefrontal cortex (mPFC) is critical for executive function, behavioral inhibition, and memory. Its high vulnerability to dementia, compared to other prefrontal regions, remains unclear. METHODS We analyzed post mortem brain tissue from 118 older subjects, including post‐stroke survivors, Alzheimer's disease; vascular ...
Dan D. Jobson, Yoshiki Hase, Lauren Walker, Tuomo Polvikoski, Ahmad A. Khundakar, Louise Allan, Raj N. Kalaria   +6 more
wiley   +1 more source

Resolving cognitive heterogeneity in white matter hyperintensities through integrated analyses of microbiome, metabolome, and brain glymphatic function

Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract INTRODUCTION Individuals with similar white matter hyperintensities (WMH) burden show heterogeneous cognitive outcomes, yet the biological mechanisms underlying this variability remain incompletely understood. METHODS We integrated 16S rDNA sequencing, untargeted metabolomics, and multi‐modal magnetic resonance imaging (MRI) to comprehensively
Xiaotao Xu, Xia Zhou, Mengwei Zhang, Jingjing Fang, Zhiqing Yan, Xiaoqun Zhu, Yongqiang Yu, Jiajia Zhu   +7 more
wiley   +1 more source