Results 31 to 40 of about 31,353 (262)

Multi-organ comparison and quantification parameters of [18F]THK-5317 uptake in preclinical mouse models of tau pathology

Frontiers in Physics, 2023
Introduction: Current small-animal PET instrumentation provides sufficient resolution, sensitivity, and quantitative accurate information on the radiotracer distribution within the whole body.
Thomas Wanek, Thomas Wanek, Severin Mairinger, Severin Mairinger, Thomas Filip, Thomas Filip, Mathilde Löbsch, Mathilde Löbsch, Johann Stanek, Johann Stanek, Claudia Kuntner, Claudia Kuntner, Claudia Kuntner   +12 more
doaj   +1 more source

Transgenic Zebrafish as a Novel Animal Model to Study Tauopathies and Other Neurodegenerative Disorders in vivo [PDF]

, 2010
Our ageing society is confronted with a dramatic increase in patients suffering from tauopathies such as Alzheimer's disease, frontotemporal dementia and others.
Haass, Christian, Paquet, Dominik, Schmid, Bettina   +2 more
core   +1 more source

Spreading of P301S Aggregated Tau Investigated in Organotypic Mouse Brain Slice Cultures

Biomolecules, 2022
Tau pathology extends throughout the brain in a prion-like fashion through connected brain regions. However, the details of the underlying mechanisms are incompletely understood.
Dhwani S. Korde, Christian Humpel
doaj   +1 more source

Mixed Brain Pathologies in Dementia: The BrainNet Europe Consortium Experience [PDF]

, 2008
Background: Dementia results from heterogeneous diseases of the brain. Mixed disease forms are increasingly recognized. Methods: We performed a survey within brain banks of BrainNet Europe to estimate the proportion of mixed disease forms underlying ...
Al-Sarraj, Safa, Alafuzoff, Irina, Arzberger, Thomas, Bogdanovic, Nenad, Budka, Herbert, Capellari, Sabina, Ferrer, Isidro, Gelpi, Ellen, Kovacs, Gabor G., Kovari, Viktor, Kretzschmar, Hans, Nagy, Zoltan, Parchi, Piero, Seilhean, Danielle, Soininen, Hilkka, Troakes, Claire   +15 more
core   +1 more source

TREM2 deficiency attenuates neuroinflammation and protects against neurodegeneration in a mouse model of tauopathy [PDF]

, 2017
Significance Alzheimer’s disease (AD) is the most common cause of dementia and is a major public health problem for which there is currently no disease-modifying treatment.
Anderson, Elise, Colonna, Marco, Finn, Mary B., Holtzmann, David M., Koscal, Lauren J., Leyns, Cheryl E. G., Robinson, Grace O., Serrano, Javier Remolina, Stewart, Floy R., Ulrich, Jason D.   +9 more
core   +2 more sources

Tauopathy differentially affects cell adhesion molecules in mouse brain: early down-regulation of nectin-3 in stratum lacunosum moleculare.

PLoS ONE, 2013
Cell adhesion molecules are important structural substrates, required for synaptic plasticity and synaptogenesis. CAMs differ widely in their expression throughout different brain regions and their specific structural and functional roles in the brain ...
Hervé Maurin, Claire Marie Seymour, Benoit Lechat, Peter Borghgraef, Herman Devijver, Tomasz Jaworski, Mathias V Schmidt, Sebastian Kuegler, Fred Van Leuven   +8 more
doaj   +1 more source

Curcumin as a Holistic Treatment for Tau Pathology

Frontiers in Pharmacology, 2022
Global forecasts for prevalence of Alzheimer’s Disease (AD) estimate that 152.8 million people will have dementia in 2050, a sharp rise from 57.4 million in 2019 (GBD 2019).
Lovesha Sivanantharajah, Amritpal Mudher
doaj   +1 more source

Monoaminergic Neuropathology in Alzheimer's disease [PDF]

, 2016
Acknowledgments This work was supported by The Croatian Science Foundation grant. no. IP-2014-09-9730 (“Tau protein hyperphosphorylation, aggregation, and trans-synaptic transfer in Alzheimer’s disease: cerebrospinal fluid analysis and assessment of ...
Bažadona, Danira, Buée, Luc, Delalle, Ivana, Giovanni, Giuseppe Di, Harrington, Charles R., Hof, Patrick R., Jovanov-Milošević, Nataša, Leko, Mirjana Babić, Silva, Rohan de, Wischik, Claude M., Wray, Selina, Šimić, Goran   +11 more
core   +1 more source

Persistent and Progressive Outer Retina Thinning in Frontotemporal Degeneration

Frontiers in Neuroscience, 2019
ObjectiveWhile Alzheimer’s disease is associated with inner retina thinning measured by spectral-domain optical coherence tomography (SD-OCT), our previous cross-sectional study suggested outer retina thinning in frontotemporal degeneration (FTD ...
Benjamin J. Kim, Murray Grossman, Delu Song, Samantha Saludades, Wei Pan, Sophia Dominguez-Perez, Joshua L. Dunaief, Tomas S. Aleman, Gui-Shuang Ying, David J. Irwin   +9 more
doaj   +1 more source

Phosphorylation of protein Tau by GSK3β prolongs survival of bigenic Tau.P301L × GSK3β mice by delaying brainstem tauopathy

Neurobiology of Disease, 2014
Tau.P301L transgenic mice suffer precocious mortality between ages 8 and 11 months, resulting from upper airway defects caused by tauopathy in autonomic brainstem circuits that control breathing (Dutschmann et al., 2010). In individual mice, the clinical
Natalia Crespo-Biel, Clara Theunis, Peter Borghgraef, Benoit Lechat, Herman Devijver, Hervé Maurin, Fred Van Leuven   +6 more
doaj   +1 more source