Results 41 to 50 of about 31,353 (262)

Developmental expression of 4-repeat-Tau induces neuronal aneuploidy in Drosophila tauopathy models [PDF]

, 2017
Tau-mediated neurodegeneration in Alzheimer's disease and tauopathies is generally assumed to start in a normally developed brain. However, several lines of evidence suggest that impaired Tau isoform expression during development could affect mitosis and
Amouyel, Philippe, Bauderlique, Hélène, Bellen, Hugo J, Bongiovanni, Antonino, Callaerts, Patrick, Demiautte, Florie, Dermaut, Bart, Dourlen, Pierre, Dupont, Cloé, Gistelinck, Marc, Lafont, Frank, Lambert, Jean-Charles, Link, Nichole, Malmanche, Nicolas, Moechars, Dieder, Royou, Anne, Vanden Broeck, Lies, Werkmeister, Elisabeth   +17 more
core   +1 more source

Atypical parkinsonism: An Update. [PDF]

, 2013
Purpose of review: This update discusses novel aspects on genetics, diagnosis, and treatments of atypical parkinsonism published over the past 2 years. Recent findings: A genome-wide association study identified new genetic risk factors for progressive ...
Hoeglinger, GU, Stamelou, M
core   +1 more source

Targeted brain-specific tauopathy compromises peripheral skeletal muscle integrity and function

Aging Brain
Tauopathies are neurodegenerative disorders in which the pathological intracellular aggregation of the protein tau causes cognitive deficits. Additionally, clinical studies report muscle weakness in populations with tauopathy.
Bryan Alava, Gabriela Hery, Silvana Sidhom, Miguel Gutierrez-Monreal, Stefan Prokop, Karyn A. Esser, Jose Abisambra   +6 more
doaj   +1 more source

Cerebrolysin™ efficacy in a transgenic model of tauopathy: role in regulation of mitochondrial structure. [PDF]

, 2014
BackgroundAlzheimer's Disease (AD) and Fronto temporal lobar dementia (FTLD) are common causes of dementia in the aging population for which limited therapeutical options are available. These disorders are associated with Tau accumulation.
Adame, Anthony, Doppler, Edith, Jech, Marion, Mante, Michael, Masliah, Eliezer, Moessler, Herbert, Novak, Philipp, Patrick, Christina, Rockenstein, Edward, Trejo, Margarita, Ubhi, Kiren   +10 more
core   +2 more sources

Targeting tauopathy with engineered tau-degrading intrabodies [PDF]

, 2019
BACKGROUND: The accumulation of pathological tau is the main component of neurofibrillary tangles and other tau aggregates in several neurodegenerative diseases, referred to as tauopathies.
Gallardo, Gilbert, Holtzman, David M, Jiang, Hong, Leyns, Cheryl E G, Lin, Kent H, Mann, Carolyn N, Ricardez, Sara M, Wong, Connie H   +7 more
core   +1 more source

Axonal stress kinase activation and tau misbehavior induced by kinesin-1 transport defects [PDF]

, 2009
Many neurodegenerative diseases exhibit axonal pathology, transport defects, and aberrant phosphorylation and aggregation of the microtubule binding protein tau. While mutant tau protein in frontotemporal dementia and parkinsonism linked to chromosome 17
Falzone, Tomas Luis, Goldstein, Lawrence S. B., Lillo, Concepción, Rodrigues, Elizabeth M., Stokin, Gorazd B., Westerman, Eileen L., Williams, David S.   +6 more
core   +1 more source

Astrogliopathy in Tauopathies [PDF]

Neuroglia, 2018
Astrocytes are involved in many diseases of the central nervous system, not only as reactive cells to neuronal damage but also as primary actors in the pathological process. Astrogliopathy is a term used to designate the involvement of astrocytes as key elements in the pathogenesis and pathology of diseases and injuries of the central nervous system ...
openaire   +2 more sources

Tau and Tauopathies [PDF]

, 2012
Tauopathies are age-related neurodegenerative diseases that are characterized by the presence of aggregates of abnormally phosphorylated tau. As tau was originally discovered as a microtubule-associated protein, it has been hypothesized that neurodegeneration results from a loss of the ability of tau to associate with microtubules.
Gloria, Lee, Chad J, Leugers
openaire   +2 more sources

Fluid Biomarkers of Disease Burden and Cognitive Dysfunction in Progressive Supranuclear Palsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Identifying objective biomarkers for progressive supranuclear palsy (PSP) is crucial to improving diagnosis and establishing clinical trial and treatment endpoints. This study evaluated fluid biomarkers in PSP versus controls and their associations with regional 18F‐PI‐2620 tau‐PET, clinical, and cognitive outcomes.
Roxane Dilcher, Charles B. Malpas, Stuart J. McDonald, William T. O’Brien, Craig Despott, Kelly L. Bertram, Matthew P. Pase, Lukas Frontzkowski, Meng Law, Terence J. O’Brien, Lucy Vivash   +10 more
wiley   +1 more source

Promoting tau secretion and propagation by hyperactive p300/CBP via autophagy-lysosomal pathway in tauopathy. [PDF]

, 2020
BackgroundThe trans-neuronal propagation of tau has been implicated in the progression of tau-mediated neurodegeneration. There is critical knowledge gap in understanding how tau is released and transmitted, and how that is dysregulated in diseases ...
Arkin, Michelle, Boxer, Adam L, Chen, Xu, Cuervo, Ana Maria, Gan, Li, Gestwicki, Jason E, Karydas, Anna, Li, Yaqiao, Miller, Bruce L, Mok, Sue-Ann, Rojas, Julio C, Tang, Yinyan, Tsai, Richard M, Wang, Chao   +13 more
core