Results 121 to 130 of about 6,842 (160)
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Stimulation of taurocholic acid synthesis and biliary excretion of lipids
American Journal of Physiology-Legacy Content, 1961The rates of excretion of taurocholic acid and lipids in the bile of the isolated perfused liver and the bile fistula rat were determined. In the bile fistula rats, there was, during the first 12 hours after cannulation, a fall in the excretion of taurocholic acid, which was then followed by an increase in the rate of excretion.
R E, KAY, C, ENTENMAN
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Gastroduodenal alkaline response to acid and taurocholate in conscious dogs
American Journal of Physiology-Gastrointestinal and Liver Physiology, 1984Alkaline secretion was measured in the fundic and antral portions of the stomach and in the upper and distal portions of the duodenum in conscious dogs under basal conditions, in response to luminal exposure of HCl and taurocholate, and after feeding.
S J, Konturek +3 more
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Taurocholic acid inhibits features of age-related macular degeneration in vitro
Experimental Eye Research, 2020Previous metabolomics studies from our lab found altered plasma levels of bile acids in patients with age-related macular degeneration (AMD) compared to controls. In this study, we investigated the ability of the bile acid taurocholic acid (TCA) to inhibit features of AMD modeled in vitro. Paraquat was used to induce oxidative stress in HRPEpiC primary
Joshua M Barnett, Milam A Brantley
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Bombesin Potentiates Taurocholic Acid-Induced Neurotensin Release in Rats
Endocrinology, 1991The hypothesis of synergistic effects between luminal stimulants and the intramural neural network in the control of intestinal neurotensin (NT) release was investigated with an isolated vascularly perfused rat jejuno-ileum. Luminal administration of low doses of taurocholic acid (TC; 1, 5, and 10 mM) provoked only a small increase in NT-like ...
Herrmann, C. +4 more
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Effect of pirenzepine and PGE2 on taurocholic acid-induced gastric lesions
Pharmacological Research Communications, 1986Cytoprotective activity of Pirenzepine (PZ) and Prostaglandin E2 (PGE2) was investigated in the gastric damage induced by taurocholic acid (TA) in the rat. Gastric mucosal potential difference (PD) and gross mucosal erosions were measured. Intravenous PZ (18 mg/kg) and PGE2 (5 micrograms/kg) prevented both the sharp decrease of PD and the gastric ...
L, Varin, A, Giachetti, A, Brambilla
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Inhibition of the synthesis of taurocholic acid by structural analogues of taurine
Biochemical Pharmacology, 1977Abstract Structural analogues of taurine that are inhibitors of the rat liver microsomal synthesis of taurocholic acid are reported. Isethionic acid, the hydroxy analogue of taurine, is the most potent inhibitor ( I 50 = 110 μM ). Aminomethanesulfonic acid, a taurine analogue which has a single carbon bridge between the amino and sulfonic acid ...
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Only free bile acid drives ileal absorption of taurocholate
American Journal of Physiology-Gastrointestinal and Liver Physiology, 1986We compared the intestinal absorption of monomeric taurocholate bound to albumin with the absorption of the free form. In the presence of albumin the apparent uptake coefficient is about three times greater than that in its absence. This result resembles the one reported previously for the liver. In the gut, however, this phenomenon is attributable to
B A, Luxon, P D, King, E L, Forker
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Intestinal Taurine and the Enterohepatic Circulation of Taurocholic Acid in the Cat
1992Taurine’s most well defined role is the conjugation of bile salts in the liver. After synthesis from cholesterol, bile salts are conjugated with taurine and/or glycine before secretion into the bile canaliculi1. When taurine is limiting, most mammals have the ability to conjugate bile salts with glycine, exceptions being the dog2 and the cat3,4, which ...
M A, Hickman, J G, Morris, Q R, Rogers
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Uptake of taurocholic acid and cholic acid in isolated hepatocytes from rainbow trout
American Journal of Physiology-Gastrointestinal and Liver Physiology, 1994The uptake of the bile acids cholate (CHA) and taurocholate (TCHA) was studied in isolated hepatocytes from rainbow trout (Oncorhynchus mykiss). Both CHA and TCHA were taken up in a concentration- and temperature-dependent manner with optimum temperature at 15 degrees C and a strikingly efficient uptake even at low temperatures (0-5 degrees C).
C M, Råbergh +4 more
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Transhepatic transport of taurocholic acid in normal and mutant analbuminemic rats
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1985To elucidate a possible function of plasma albumin in vectorial transport of various cholephilic organic anions, such as bile acids, plasma clearance and transhepatic transport of radioactive taurocholate were studied in vivo in normal and mutant analbuminemic rats. Intravenous administration of taurocholate was followed by its rapid disappearance from
M, Inoue, Y, Morino, S, Nagase
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