Results 1 to 10 of about 249,034 (202)

Changes in TCA cycle and TCA cycle-related metabolites in plasma upon citric acid administration in rats [PDF]

Heliyon, 2021
Recent studies have reported that plasma levels of tricarboxylic acid (TCA) cycle metabolites and TCA cycle-related metabolite change in patients with chronic fatigue syndrome (CFS) and in healthy humans after exercise.
Yurie Hara, Satoshi Kume, Yosky Kataoka, Nakamichi Watanabe   +3 more
doaj   +3 more sources

Emerging role of the TCA cycle and its metabolites in lung disease [PDF]

Frontiers in Physiology
The TCA cycle is a central pathway for oxidative phosphorylation in eukaryotic mitochondria, plays a role in energy production and biosynthesis, and can alter cellular function in a variety of ways.
Xinan Lu, Aijun Zhang, Huaying Wang, Xinjia Xu, Liping Chen, Lingfang Luo   +5 more
doaj   +2 more sources

Noncanonical TCA cycle fosters canonical TCA cycle and mitochondrial integrity in acute myeloid leukemia. [PDF]

Cancer Sci
AbstractCancer cells rely on mitochondrial oxidative phosphorylation (OXPHOS) and the noncanonical tricarboxylic acid (TCA) cycle. In this paper, we shed light on the vital role played by the noncanonical TCA cycle in a host‐side concession to mitochondria, especially in highly energy‐demanding malignant tumor cells.
Watanabe A, Tipgomut C, Totani H, Yoshimura K, Iwano T, Bashiri H, Chua LH, Yang C, Suda T.   +8 more
europepmc   +3 more sources

Mitochondrial TCA cycle metabolites control physiology and disease [PDF]

Nature Communications, 2020
Mitochondrial metabolites contribute to more than biosynthesis, and it is clear that they influence multiple cellular functions in a variety of ways. Here, Martínez-Reyes and Chandel review key metabolites and describe their effects on processes involved
Inmaculada Martínez-Reyes, Navdeep S. Chandel   +1 more
doaj   +3 more sources

TCA cycle impairment leads to PIN2 internalization and degradation via reduced MAB4 level and ARA6 components in Arabidopsis roots [PDF]

Frontiers in Plant Science
The mitochondrial pyruvate dehydrogenase complex (PDC) plays a crucial role in linking the glycolysis pathway and the tricarboxylic acid (TCA) cycle. Previously, we reported that a mutation of MAB1, encoding an E1β subunit of PDC, affects the abundance ...
Xiaomin Song, Xiaomin Song, Iwai Ohbayashi, Iwai Ohbayashi, Iwai Ohbayashi, Song Sun, Qiuli Wang, Qiuli Wang, Yi Yang, Yi Yang, Mengyuan Lu, Mengyuan Lu, Yuanyuan Liu, Shinichiro Sawa, Shinichiro Sawa, Shinichiro Sawa, Shinichiro Sawa, Masahiko Furutani, Masahiko Furutani, Masahiko Furutani, Masahiko Furutani, Masahiko Furutani   +21 more
doaj   +2 more sources

A thermodynamic bottleneck in the TCA cycle contributes to acetate overflow in Staphylococcus aureus [PDF]

mSphere
During aerobic growth, S. aureus relies on acetate overflow metabolism, a process where glucose is incompletely oxidized to acetate, for its bioenergetic needs. Acetate is not immediately captured as a carbon source and is excreted as waste by cells. The
Nabia Shahreen, Jongsam Ahn, Adil Alsiyabi, Niaz Bahar Chowdhury, Dhananjay Shinde, Sujata S. Chaudhari, Kenneth W. Bayles, Vinai C. Thomas, Rajib Saha   +8 more
doaj   +2 more sources

Beyond energy: how TCA cycle-derived metabolites regulate gene expression and inflammation in the nucleus [PDF]

Journal of Inflammation
Immune cells can rewire their metabolism in response to various stimuli. Crosstalk between the nucleus and mitochondria allows for tight regulation of this metabolic reprogramming.
Jaiya Randhawa, Eva M. Pålsson-McDermott   +1 more
doaj   +2 more sources

Mitochondrial dysfunction-mediated metabolic remodeling of TCA cycle promotes Parkinson’s disease through inhibition of H3K4me3 demethylation [PDF]

Cell Death Discovery
Parkinson’s disease (PD), a neurodegenerative disorder caused by complex factors, is usually associated to mitochondrial dysfunctions but the links between such disorder and PD remain object of research.
Xiaoyuan Zhang, Fali Zhang, Yue Zeng, Aiying Li, Jiamao Yan, Pei Li, Kexin Qin, Teng Zhang, Jiaojiao Huang, Minghui Zhao, Massimo De Felici, Yang Zhou, Wei Shen   +12 more
doaj   +2 more sources

Malic Enzyme, not Malate Dehydrogenase, Mainly Oxidizes Malate That Originates from the Tricarboxylic Acid Cycle in Cyanobacteria

mBio, 2022
Oxygenic photoautotrophic bacteria, cyanobacteria, have the tricarboxylic acid (TCA) cycle, and metabolite production using the cyanobacterial TCA cycle has been spotlighted recently. The unicellular cyanobacterium Synechocystis sp.
Noriaki Katayama, Kaori Iwazumi, Hiromi Suzuki, Takashi Osanai, Shoki Ito   +4 more
doaj   +1 more source

Tricarboxylic Acid (TCA) Cycle Intermediates: Regulators of Immune Responses

Life, 2021
The tricarboxylic acid cycle (TCA) is a series of chemical reactions used in aerobic organisms to generate energy via the oxidation of acetylcoenzyme A (CoA) derived from carbohydrates, fatty acids and proteins.
Inseok Choi, Hyewon Son, Jea-Hyun Baek
doaj   +1 more source