Results 11 to 20 of about 249,034 (202)

The Role of Tricarboxylic Acid Cycle Metabolites in Viral Infections

Frontiers in Cellular and Infection Microbiology, 2021
Host cell metabolism is essential for the viral replication cycle and, therefore, for productive infection. Energy (ATP) is required for the receptor-mediated attachment of viral particles to susceptible cells and for their entry into the cytoplasm. Host
Francisco Javier Sánchez-García, Celia Angélica Pérez-Hernández, Miguel Rodríguez-Murillo, María Maximina Bertha Moreno-Altamirano   +3 more
doaj   +1 more source

Disruption of the TCA cycle reveals an ATF4-dependent integration of redox and amino acid metabolism

eLife, 2021
The Tricarboxylic Acid (TCA) Cycle is arguably the most critical metabolic cycle in physiology and exists as an essential interface coordinating cellular metabolism, bioenergetics, and redox homeostasis.
Dylan Gerard Ryan, Ming Yang, Hiran A Prag, Giovanny Rodriguez Blanco, Efterpi Nikitopoulou, Marc Segarra-Mondejar, Christopher A Powell, Tim Young, Nils Burger, Jan Lj Miljkovic, Michal Minczuk, Michael P Murphy, Alex von Kriegsheim, Christian Frezza   +13 more
doaj   +1 more source

The TGF-β/HDAC7 axis suppresses TCA cycle metabolism in renal cancer

JCI Insight, 2021
Mounting evidence points to alterations in mitochondrial metabolism in renal cell carcinoma (RCC). However, the mechanisms that regulate the TCA cycle in RCC remain uncharacterized.
Hyeyoung Nam, Anirban Kundu, Suman Karki, Garrett J. Brinkley, Darshan S. Chandrashekar, Richard L. Kirkman, Juan Liu, Maria V. Liberti, Jason W. Locasale, Tanecia Mitchell, Sooryanarayana Varambally, Sunil Sudarshan   +11 more
doaj   +1 more source

The existence of a nonclassical TCA cycle in the nucleus that wires the metabolic-epigenetic circuitry

Signal Transduction and Targeted Therapy, 2021
The scope and variety of the metabolic intermediates from the mitochondrial tricarboxylic acid (TCA) cycle that are engaged in epigenetic regulation of the chromatin function in the nucleus raise an outstanding question about how timely and precise ...
Xujun Liu, Wenzhe Si, Lin He, Jianguo Yang, Yani Peng, Jie Ren, Xiaoping Liu, Tong Jin, Huajing Yu, Zihan Zhang, Xiao Cheng, Wenting Zhang, Lu Xia, Yunchao Huang, Yue Wang, Shumeng Liu, Lin Shan, Yu Zhang, Xiaohan Yang, Haixia Li, Jing Liang, Luyang Sun, Yongfeng Shang   +22 more
doaj   +1 more source

Succinyl-CoA:acetate CoA-transferase functioning in the oxidative tricarboxylic acid cycle in Desulfurella acetivorans

Frontiers in Microbiology, 2022
Desulfurella acetivorans is a strictly anaerobic sulfur-reducing deltaproteobacterium that possesses a very dynamic metabolism with the ability to revert the citrate synthase version of the tricarboxylic acid (TCA) cycle for autotrophic growth (reversed ...
Eugenio Pettinato, Pauline Böhnert, Ivan A. Berg   +2 more
doaj   +1 more source

Localization of TCA cycle dehydrogenases in the mitochondria [PDF]

, 1967
The site of localization of TCA cycle dehydrogenases in mitochondria has been investigated by observing the dehydrogenase activities and fine structure of the fractionated samples after freezing and thawing or sonication of beef heart and rat liver ...
Inaba, Kozo, Oda, Takuzo, Wakabayashi, Akira   +2 more
core   +1 more source

Mitochondrial metabolism of sexual and asexual blood stages of the malaria parasite Plasmodium falciparum [PDF]

, 2013
BACKGROUND: The carbon metabolism of the blood stages of Plasmodium falciparum, comprising rapidly dividing asexual stages and non-dividing gametocytes, is thought to be highly streamlined, with glycolysis providing most of the cellular ATP.
Hwa H Chua, Iveta Bottova, James I MacRae, Jennifer M Chambers, Leann Tilley, Malcolm J McConville, Matthew WA Dixon, Megan K Dearnley, Shannon Kenny   +8 more
core   +1 more source

A tricarboxylic acid cycle-based machine learning model to select effective drug targets for the treatment of esophageal squamous cell carcinoma

Frontiers in Pharmacology, 2023
Background: The tricarboxylic acid cycle (TCA cycle) is an important metabolic pathway and closely related to tumor development. However, its role in the development of esophageal squamous cell carcinoma (ESCC) has not been fully investigated.Methods ...
Yicheng Liang, Yicheng Liang, Yicheng Liang, Binghua Tan, Binghua Tan, Minjun Du, Bing Wang, Yushun Gao, Minghui Wang, Minghui Wang   +9 more
doaj   +1 more source

Fatty acid feedstocks enable a highly efficient glyoxylate‐TCA cycle for high‐yield production of β‐alanine

mLife, 2022
Metabolic engineering to produce tricarboxylic acid (TCA) cycle‐derived chemicals is usually associated with problems of low production yield and impaired cellular metabolism. In this work, we found that fatty acid (FA) feedstocks could enable high‐yield
Yingchun Miao, Jiao Liu, Xuanlin Wang, Bo Liu, Weifeng Liu, Yong Tao   +5 more
doaj   +1 more source

Glucose production, gluconeogenesis, and hepatic tricarboxylic acid cycle fluxes measured by nuclear magnetic resonance analysis of a single glucose derivative [PDF]

, 2004
A triple-tracer method was developed to provide absolute fluxes contributing to endogenous glucose production and hepatic tricarboxylic acid (TCA) cycle fluxes in 24-h-fasted rats by 2H and 13C nuclear magnetic resonance (NMR) analysis of a single ...
Burgess, Shawn C., Jin, Eunsook S., Jones, John G., Malloy, Craig R., Merritt, Matthew, Sherry, A. Dean   +5 more
core   +1 more source