PLoS Genetics, 2017 Morphological transitions and metabolic regulation are critical for the human fungal pathogen Candida albicans to adapt to the changing host environment. In this study, we generated a library of central metabolic pathway mutants in the tricarboxylic acid
Li Tao +5 more
doaj +1 more source
TCA cycle-powered synthesis of fucosylated oligosaccharides [PDF]
Glycobiology, 2018 Microbial catalysis has recently emerged as one of the most promising approaches in oligosaccharide synthesis. However, despite significant progress, microbial synthesis still requires much improvement in efficiency and in reduction of process complexity. Additionally, given the stunning diversity and many varied applications of glycans, broadening the
Ningzi, Guan +4 more
openaire +2 more sources
Initial B Cell Activation Induces Metabolic Reprogramming and Mitochondrial Remodeling. [PDF]
, 2018 B lymphocytes provide adaptive immunity by generating antigen-specific antibodies and supporting the activation of T cells. Little is known about how global metabolism supports naive B cell activation to enable an effective immune response.
Ahsan, Fasih M +4 more
core +2 more sources
Systemic alterations of tricarboxylic acid cycle enzymes in Alzheimer’s disease
Frontiers in Neuroscience, 2023 Mitochondrial dysfunction, especially tricarboxylic acid (TCA) cycle arrest, is strongly associated with Alzheimer’s disease (AD), however, its systemic alterations in the central and peripheral of AD patients are not well defined.
Dongdong Jia +3 more
doaj +1 more source
Glutamine synthetase activity fuels nucleotide biosynthesis and supports growth of glutamine-restriced glioblastoma [PDF]
, 2015 L-Glutamine (Gln) functions physiologically to balance the carbon and nitrogen requirements of tissues. It has been proposed that in cancer cells undergoing aerobic glycolysis, accelerated anabolism is sustained by Gln-derived carbons, which replenish ...
Ahmed, Shafiq +19 more
core +1 more source
Environment Impacts the Metabolic Dependencies of Ras-Driven Non-Small Cell Lung Cancer [PDF]
, 2018 Cultured cells convert glucose to lactate, and glutamine is the major source of tricarboxylic acid (TCA)-cycle carbon, but whether the same metabolic phenotype is found in tumors is less studied.
Bauer, Matthew R. +19 more
core +1 more source
BCKDH: the missing link in apicomplexan mitochondrial metabolism is required for full virulence of Toxoplasma gondii and Plasmodium berghei [PDF]
, 2014 While the apicomplexan parasites Plasmodium falciparum and Toxoplasma gondii are thought to primarily depend on glycolysis for ATP synthesis, recent studies have shown that they can fully catabolize glucose in a canonical TCA cycle.
Barrett, Michael P. +11 more
core +1 more source
In-depth profiling of lysine-producing Corynebacterium glutamicum by combined analysis of the transcriptome, metabolome, and fluxome [PDF]
, 2004 An in-depth analysis of the intracellular metabolite concentrations, metabolic fluxes, and gene expression (metabolome, fluxome, and transcriptome, respectively) of lysine-producing Corynebacterium glutamicum ATCC 13287 was performed at different stages ...
Kromer, Jens Olaf +4 more
core +1 more source
Early pH Changes in Musculoskeletal Tissues upon Injury-Aerobic Catabolic Pathway Activity Linked to Inter-Individual Differences in Local pH [PDF]
, 2020 Local pH is stated to acidify after bone fracture. However, the time course and degree of acidification remain unknown. Whether the acidification pattern within a fracture hematoma is applicable to adjacent muscle hematoma or is exclusive to this ...
Berkmann, Julia C. +8 more
core +2 more sources
mBio, 2013 A recent controversial hypothesis suggested that the bactericidal action of antibiotics is due to the generation of endogenous reactive oxygen species (ROS), a process requiring the citric acid cycle (tricarboxylic acid [TCA] cycle).
Vinai Chittezham Thomas +14 more
doaj +1 more source